SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5U5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.88A 1iepA-5eykA:
17.5		 1iepA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
None
None
 0.59A 1iepB-5eykA:
17.5		 1iepB-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
None
 0.68A 1iepB-5eykA:
17.5		 1iepB-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 9 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LEU A 154
ALA A 173
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
 0.51A 1muoA-5eykA:
28.0		 1muoA-5eykA:
67.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
None
None
 0.52A 1opjA-5eykA:
17.0		 1opjA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-4.7A)
None
 0.70A 1opjA-5eykA:
17.0		 1opjA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 VAL A 107
ALA A 120
PHE A 172
GLY A 176
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
None
None
 0.85A 1opjB-5eykA:
9.8		 1opjB-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 9 LEU A  99
VAL A 107
ALA A 120
ALA A 173
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.56A 1xbbA-5eykA:
25.1		 1xbbA-5eykA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.75A 2gqgA-5eykA:
21.2		 2gqgA-5eykA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.91A 2hyyA-5eykA:
17.5		 2hyyA-5eykA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.75A 2hyyB-5eykA:
17.5		 2hyyB-5eykA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.81A 2hyyC-5eykA:
17.7		 2hyyC-5eykA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 VAL A 107
ALA A 120
PHE A 172
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-4.7A)
None
None
 0.83A 2hyyD-5eykA:
5.4		 2hyyD-5eykA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.53A 2itoA-5eykA:
24.8		 2itoA-5eykA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.76A 2ityA-5eykA:
19.3		 2ityA-5eykA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
GLY A 100
VAL A 107
LYS A 122
LEU A 168
ALA A 173
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
 0.48A 2ivuA-5eykA:
26.0		 2ivuA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 GLY A 100
VAL A 107
ALA A 120
LEU A 154
LEU A 170
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
None
 0.73A 2wgjA-5eykA:
12.1		 2wgjA-5eykA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 VAL A 107
ALA A 120
LEU A 154
LEU A 170
GLY A 176
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
None
None
 0.93A 2wgjA-5eykA:
12.1		 2wgjA-5eykA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 9 LEU A  99
VAL A 107
ALA A 120
LEU A 170
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.89A 2xp2A-5eykA:
24.8		 2xp2A-5eykA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 10 ARG A  97
LEU A  99
ALA A 120
LYS A 122
LEU A 170
GLY A 176
LEU A 223
 None
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.75A 3aoxA-5eykA:
24.2		 3aoxA-5eykA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
GLY A 100
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.40A 3c7qA-5eykA:
14.4		 3c7qA-5eykA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 10 LEU A  99
VAL A 107
LYS A 122
PHE A 172
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
None
 0.63A 3cs9A-5eykA:
17.3		 3cs9A-5eykA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		4 / 6 LEU A  99
VAL A 107
LYS A 122
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-2.6A)
None
 0.46A 3cs9D-5eykA:
8.9		 3cs9D-5eykA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
ILE A 144
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
None
5U5  A 401 (-4.7A)
None
None
 1.14A 3gvuA-5eykA:
17.7		 3gvuA-5eykA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		4 / 7 LEU A 154
VAL A 337
MET A 224
ARG A 331
 5U5  A 401 (-4.8A)
None
None
None
 1.21A 3ik3B-5eykA:
17.1		 3ik3B-5eykA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.89A 3k5vA-5eykA:
9.8		 3k5vA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.89A 3k5vB-5eykA:
12.5		 3k5vB-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 9 ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
 5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.72A 3miyB-5eykA:
18.2		 3miyB-5eykA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-4.7A)
None
None
 0.83A 3ms9A-5eykA:
17.3		 3ms9A-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.88A 3ms9B-5eykA:
17.3		 3ms9B-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-4.7A)
None
None
 0.84A 3mssA-5eykA:
17.5		 3mssA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
None
None
 0.55A 3mssB-5eykA:
17.6		 3mssB-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.77A 3mssB-5eykA:
17.6		 3mssB-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
None
None
 0.52A 3mssC-5eykA:
17.5		 3mssC-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-4.7A)
None
 0.78A 3mssC-5eykA:
17.5		 3mssC-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.94A 3mssD-5eykA:
17.7		 3mssD-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.86A 3pyyA-5eykA:
17.6		 3pyyA-5eykA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
None
None
 0.60A 3pyyA-5eykA:
17.6		 3pyyA-5eykA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
PHE A 172
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
None
 0.79A 3pyyA-5eykA:
17.6		 3pyyA-5eykA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.81A 3ug2A-5eykA:
25.1		 3ug2A-5eykA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.38A 4ag8A-5eykA:
22.5		 4ag8A-5eykA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.36A 4agcA-5eykA:
22.1		 4agcA-5eykA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 11 LEU A  99
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.48A 4agdA-5eykA:
21.8		 4agdA-5eykA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 9 LEU A  99
VAL A 107
ALA A 120
LEU A 170
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.85A 4anqA-5eykA:
24.5		 4anqA-5eykA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 9 LEU A  99
VAL A 107
ALA A 120
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.70A 4ansA-5eykA:
24.5		 4ansA-5eykA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 ALA A 120
LYS A 122
ILE A 153
LEU A 154
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.8A)
5U5  A 401 (-4.7A)
None
None
 0.83A 4c8bB-5eykA:
23.3		 4c8bB-5eykA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 10 LEU A  99
GLY A 100
VAL A 107
ALA A 120
ALA A 173
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
 0.36A 4ckjA-5eykA:
25.9		 4ckjA-5eykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.60A 4i22A-5eykA:
15.2		 4i22A-5eykA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 11 VAL A 107
ALA A 120
LYS A 122
LEU A 170
LEU A 223
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-4.7A)
 0.64A 4iaaA-5eykA:
28.3		 4iaaA-5eykA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.7A)
 0.41A 4ifgA-5eykA:
25.3		 4ifgA-5eykA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		3 / 3 ILE A 144
MET A 156
ARG A 155
 None
5U5  A 401 (-4.8A)
None
 0.86A 4lnwA-5eykA:
undetectable		 4lnwA-5eykA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		3 / 3 ILE A 144
MET A 156
ARG A 155
 None
5U5  A 401 (-4.8A)
None
 0.85A 4lnxA-5eykA:
undetectable		 4lnxA-5eykA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 11 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 154
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.8A)
5U5  A 401 (-4.7A)
 0.51A 4o0sA-5eykA:
31.4		 4o0sA-5eykA:
68.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 6 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.7A)
 0.45A 4o0wA-5eykA:
30.4		 4o0wA-5eykA:
68.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.61A 4twpA-5eykA:
25.4		 4twpA-5eykA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.68A 4twpB-5eykA:
16.1		 4twpB-5eykA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 6 LEU A  99
VAL A 107
ILE A 153
ARG A 140
ILE A 232
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
None
TPO  A 248 ( 4.5A)
None
 1.06A 4tyjA-5eykA:
19.6		 4tyjA-5eykA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 9 LEU A  99
VAL A 107
ALA A 120
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.59A 4u5jB-5eykA:
25.2		 4u5jB-5eykA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.55A 4wkqA-5eykA:
25.0		 4wkqA-5eykA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.73A 4xeyB-5eykA:
24.4		 4xeyB-5eykA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 9 LEU A  99
VAL A 107
ALA A 120
LEU A 170
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.98A 5aaaA-5eykA:
24.8		 5aaaA-5eykA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 10 LEU A  99
VAL A 107
ALA A 120
LYS A 122
LEU A 170
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.81A 5aabA-5eykA:
24.5		 5aabA-5eykA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 10 LEU A  99
VAL A 107
ALA A 120
LEU A 170
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.84A 5aacA-5eykA:
24.6		 5aacA-5eykA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 10 LEU A  99
VAL A 107
ALA A 120
LYS A 122
LEU A 170
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.75A 5aacA-5eykA:
24.6		 5aacA-5eykA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.81A 5ajqA-5eykA:
25.2		 5ajqA-5eykA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
GLY A 100
ALA A 120
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.81A 5ajqA-5eykA:
25.2		 5ajqA-5eykA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
GLY A 100
PHE A 172
GLY A 176
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
None
 0.98A 5ajqA-5eykA:
25.2		 5ajqA-5eykA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 ARG A  97
LEU A  99
ALA A 120
LEU A 154
GLY A 176
LEU A 223
 None
5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-4.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.68A 5h2uC-5eykA:
22.8		 5h2uC-5eykA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 12 GLY A 102
VAL A 107
ALA A 120
LYS A 122
LEU A 154
 5U5  A 401 ( 4.6A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.8A)
 0.81A 5hieA-5eykA:
22.3		 5hieA-5eykA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 12 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 154
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.8A)
 0.55A 5hieC-5eykA:
22.7		 5hieC-5eykA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		8 / 11 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LEU A 170
ALA A 173
GLU A 177
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.3A)
5U5  A 401 (-4.7A)
 0.44A 5lvnA-5eykA:
27.5		 5lvnA-5eykA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 170
GLY A 176
GLU A 177
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-3.3A)
 0.47A 5mafA-5eykA:
30.3		 5mafA-5eykA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 12 LEU A 109
ALA A 120
PHE A 172
GLY A 176
LEU A 223
 None
5U5  A 401 (-3.5A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.20A 5te0A-5eykA:
26.7		 5te0A-5eykA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 12 LEU A  99
GLY A 100
VAL A 107
ALA A 120
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
None
 0.46A 5xv7A-5eykA:
19.5		 5xv7A-5eykA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.7A)
 0.74A 5yu9A-5eykA:
21.9		 5yu9A-5eykA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.7A)
 0.72A 5yu9B-5eykA:
22.3		 5yu9B-5eykA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		5 / 12 VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
 5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
 0.61A 5yu9C-5eykA:
15.7		 5yu9C-5eykA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		6 / 12 LEU A  99
VAL A 107
ALA A 120
ALA A 173
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.4A)
None
 0.56A 5zv2A-5eykA:
18.9		 5zv2A-5eykA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5eyk AURORA KINASE B-A
(Xenopus
laevis) 		7 / 12 LEU A  99
VAL A 107
ALA A 120
LYS A 122
ALA A 173
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.4A)
None
 0.63A 5zv2B-5eykA:
18.8		 5zv2B-5eykA:
14.65