SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5U3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
VAL A 981
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.57A 1fmoE-5f1zA:
24.5		 1fmoE-5f1zA:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.81A 1m17A-5f1zA:
31.5		 1m17A-5f1zA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.63A 1muoA-5f1zA:
7.7		 1muoA-5f1zA:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A 951
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.60A 1t46A-5f1zA:
28.5		 1t46A-5f1zA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 7 ASN A1028
HIS A1021
PHE A1042
ILE A1007
 5U3  A1200 (-4.7A)
None
None
None
 1.27A 1tdnA-5f1zA:
undetectable		 1tdnA-5f1zA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 5U3  A1200 (-3.5A)
None
None
None
None
5U3  A1200 ( 4.9A)
 1.00A 1uwhA-5f1zA:
26.1		 1uwhA-5f1zA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 ALA A 928
LYS A 930
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 5U3  A1200 (-3.5A)
None
None
None
None
None
5U3  A1200 ( 4.9A)
 0.96A 1uwhB-5f1zA:
25.8		 1uwhB-5f1zA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 903
VAL A 911
ALA A 928
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.52A 1xbbA-5f1zA:
32.4		 1xbbA-5f1zA:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
GLY A 984
ASP A 988
LEU A1030
ASP A1041
PHE A1042
 5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
None
 0.99A 1xkkA-5f1zA:
24.1		 1xkkA-5f1zA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
LYS A 930
VAL A 981
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
None
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.60A 2eufB-5f1zA:
20.7		 2eufB-5f1zA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 11 GLY A 904
GLY A 906
VAL A 911
MET A 978
TYR A 980
SER A 985
LEU A1030
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
 0.73A 2evaA-5f1zA:
27.0		 2evaA-5f1zA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 11 GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
SER A 985
LEU A1030
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
 0.44A 2evaA-5f1zA:
27.0		 2evaA-5f1zA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
VAL A 981
ASN A1028
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 ( 4.9A)
 0.51A 2fumA-5f1zA:
26.4		 2fumA-5f1zA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 ( 4.9A)
 0.55A 2fumB-5f1zA:
26.3		 2fumB-5f1zA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
 0.49A 2fumC-5f1zA:
24.3		 2fumC-5f1zA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
GLY A 904
VAL A 911
VAL A 981
ASN A1028
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 ( 4.9A)
 0.78A 2fumC-5f1zA:
24.3		 2fumC-5f1zA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
ASN A1028
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.7A)
5U3  A1200 ( 4.9A)
 0.76A 2fumD-5f1zA:
24.4		 2fumD-5f1zA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.60A 2gqgB-5f1zA:
31.8		 2gqgB-5f1zA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.87A 2itoA-5f1zA:
29.8		 2itoA-5f1zA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.71A 2itzA-5f1zA:
30.0		 2itzA-5f1zA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
LYS A 930
GLU A 947
LEU A 951
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
None
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.62A 2ivuA-5f1zA:
33.2		 2ivuA-5f1zA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ALA A 928
GLY A 984
LEU A1030
GLY A1040
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.70A 2xp2A-5f1zA:
28.2		 2xp2A-5f1zA:
31.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 VAL A 911
ALA A 928
ILE A 960
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.54A 2y7jC-5f1zA:
20.8		 2y7jC-5f1zA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 VAL A 911
ALA A 928
ILE A 960
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.58A 2y7jD-5f1zA:
26.2		 2y7jD-5f1zA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 903
VAL A 911
LYS A 930
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.4A)
 0.70A 3cs9D-5f1zA:
23.7		 3cs9D-5f1zA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		11 / 12 LEU A 903
GLY A 904
GLY A 909
VAL A 911
ALA A 928
LYS A 930
MET A 978
SER A 985
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
None
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
None
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.35A 3eygA-5f1zA:
39.2		 3eygA-5f1zA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		11 / 12 LEU A 903
GLY A 904
GLY A 909
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
SER A 985
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
None
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.60A 3fupA-5f1zA:
39.1		 3fupA-5f1zA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.46A 3fupB-5f1zA:
39.0		 3fupB-5f1zA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.38A 3g0eA-5f1zA:
25.8		 3g0eA-5f1zA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.47A 3g0fA-5f1zA:
22.6		 3g0fA-5f1zA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.37A 3g0fB-5f1zA:
22.2		 3g0fB-5f1zA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.53A 3g5dA-5f1zA:
29.8		 3g5dA-5f1zA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.72A 3g5dB-5f1zA:
29.4		 3g5dB-5f1zA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.69A 3k54A-5f1zA:
28.4		 3k54A-5f1zA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 ( 4.9A)
 0.50A 3lxkA-5f1zA:
37.3		 3lxkA-5f1zA:
47.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.68A 3lxkA-5f1zA:
37.3		 3lxkA-5f1zA:
47.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		11 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
ILE A 960
TYR A 980
VAL A 981
SER A 985
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.42A 3lxnA-5f1zA:
40.2		 3lxnA-5f1zA:
89.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.48A 3octA-5f1zA:
28.2		 3octA-5f1zA:
32.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 GLY A 904
VAL A 911
ALA A 928
LYS A 930
LEU A 951
ILE A 960
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
 0.74A 3ohtA-5f1zA:
5.7		 3ohtA-5f1zA:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.76A 3qlgA-5f1zA:
28.0		 3qlgA-5f1zA:
33.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 VAL A 911
ALA A 928
GLU A 947
LEU A 951
ILE A 960
TYR A 980
LEU A1014
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
 1.03A 3rgfA-5f1zA:
15.8		 3rgfA-5f1zA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.26A 3sxrA-5f1zA:
29.8		 3sxrA-5f1zA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.25A 3sxrB-5f1zA:
29.6		 3sxrB-5f1zA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 ALA A 928
LYS A 930
LEU A 976
MET A 978
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.85A 3ug2A-5f1zA:
26.8		 3ug2A-5f1zA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.91A 3ug2A-5f1zA:
26.8		 3ug2A-5f1zA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
 0.52A 3wzdA-5f1zA:
28.3		 3wzdA-5f1zA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A 951
GLY A 984
LEU A1014
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
None
 0.70A 3wzeA-5f1zA:
28.6		 3wzeA-5f1zA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1014
HIS A1021
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
None
None
 0.53A 3wzeA-5f1zA:
28.6		 3wzeA-5f1zA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A1014
HIS A1021
ARG A1022
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
None
None
5U3  A1200 (-4.4A)
 1.19A 3zosA-5f1zA:
27.1		 3zosA-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 ILE A 950
ILE A 959
ILE A 960
TYR A 980
ILE A1039
 None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
 0.45A 3zosA-5f1zA:
27.0		 3zosA-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 ILE A 950
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 None
None
None
5U3  A1200 (-4.5A)
None
 0.74A 3zosA-5f1zA:
27.0		 3zosA-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 ALA A 928
LYS A 930
GLU A 947
ILE A 960
LEU A1014
HIS A1021
ARG A1022
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
None
None
None
5U3  A1200 (-4.4A)
 1.19A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 ILE A 950
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 None
None
None
5U3  A1200 (-4.5A)
None
 0.73A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 903
ILE A 950
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 (-3.8A)
None
None
5U3  A1200 (-4.5A)
None
 0.46A 3zosB-5f1zA:
27.1		 3zosB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.51A 4ag8A-5f1zA:
28.8		 4ag8A-5f1zA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.53A 4agcA-5f1zA:
28.2		 4agcA-5f1zA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ALA A 928
MET A 978
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.60A 4ansA-5f1zA:
27.7		 4ansA-5f1zA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1014
HIS A1021
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
None
 0.81A 4asdA-5f1zA:
28.3		 4asdA-5f1zA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A 951
GLY A 984
LEU A1014
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
None
 0.91A 4asdA-5f1zA:
28.3		 4asdA-5f1zA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
GLU A 947
ILE A 950
ILE A 960
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.4A)
 0.93A 4bkjB-5f1zA:
27.4		 4bkjB-5f1zA:
34.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 5 VAL A 911
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
None
 0.48A 4c8bA-5f1zA:
24.6		 4c8bA-5f1zA:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
SER A 985
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
 0.41A 4ckjA-5f1zA:
32.7		 4ckjA-5f1zA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.76A 4i22A-5f1zA:
28.4		 4i22A-5f1zA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
LEU A 976
GLY A 984
ASP A 988
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.95A 4i22A-5f1zA:
28.4		 4i22A-5f1zA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.76A 4mxoB-5f1zA:
29.2		 4mxoB-5f1zA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.68A 4mxxB-5f1zA:
22.3		 4mxxB-5f1zA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.60A 4mxyB-5f1zA:
29.1		 4mxyB-5f1zA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.60A 4mxzB-5f1zA:
29.1		 4mxzB-5f1zA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 11 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.92A 4o0sA-5f1zA:
21.4		 4o0sA-5f1zA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.4A)
 0.42A 4o0wA-5f1zA:
20.1		 4o0wA-5f1zA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 8 GLY A 906
VAL A 911
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.58A 4ogrA-5f1zA:
26.8		 4ogrA-5f1zA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 GLY A 906
VAL A 911
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.52A 4ogrI-5f1zA:
26.8		 4ogrI-5f1zA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
LYS A 930
TYR A 980
GLY A 984
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.78A 4otwA-5f1zA:
28.8		 4otwA-5f1zA:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 ALA A 928
LYS A 930
GLU A 947
TYR A 980
LEU A1030
ASP A1041
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.85A 4qmsA-5f1zA:
27.2		 4qmsA-5f1zA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A1030
GLY A1040
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.71A 4r7iA-5f1zA:
27.6		 4r7iA-5f1zA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 10 ALA A 928
LYS A 930
ILE A 960
VAL A 981
LEU A1030
 5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.4A)
 0.59A 4rz7A-5f1zA:
23.3		 4rz7A-5f1zA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
LYS A 930
SER A 985
GLY A1040
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.9A)
None
 1.08A 4rzvB-5f1zA:
26.8		 4rzvB-5f1zA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.75A 4twpA-5f1zA:
32.0		 4twpA-5f1zA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 903
VAL A 911
ILE A 959
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
None
 0.53A 4tyjA-5f1zA:
28.7		 4tyjA-5f1zA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 903
VAL A 911
LYS A 930
ILE A 959
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
None
 0.67A 4tyjA-5f1zA:
28.7		 4tyjA-5f1zA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
GLU A 947
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
None
None
5U3  A1200 (-4.5A)
None
 0.67A 4u0iA-5f1zA:
28.0		 4u0iA-5f1zA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.45A 4u5jB-5f1zA:
29.3		 4u5jB-5f1zA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.61A 4v01A-5f1zA:
28.5		 4v01A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 903
VAL A 911
LYS A 930
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.50A 4v01A-5f1zA:
28.5		 4v01A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 9 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.50A 4v01B-5f1zA:
28.5		 4v01B-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.75A 4v04A-5f1zA:
22.9		 4v04A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
VAL A 911
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.63A 4v04B-5f1zA:
28.2		 4v04B-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
VAL A 911
LYS A 930
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.57A 4v04B-5f1zA:
28.2		 4v04B-5f1zA:
35.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 LEU A 903
ALA A 928
MET A 978
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.4A)
 0.53A 4wboB-5f1zA:
23.0		 4wboB-5f1zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 6 ARG A 901
LEU A 903
ALA A 928
MET A 978
LEU A1030
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.4A)
 1.08A 4wboC-5f1zA:
23.2		 4wboC-5f1zA:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.60A 4wkqA-5f1zA:
32.6		 4wkqA-5f1zA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
LYS A 930
GLU A 947
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
None
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.81A 4wkqA-5f1zA:
32.6		 4wkqA-5f1zA:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 5 LEU A 897
GLU A 925
MET A 978
LEU A 976
 None
None
5U3  A1200 ( 4.0A)
None
 1.13A 4xi3B-5f1zA:
undetectable		 4xi3B-5f1zA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.61A 4xliA-5f1zA:
32.0		 4xliA-5f1zA:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.55A 4xliB-5f1zA:
32.3		 4xliB-5f1zA:
33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
LYS A 930
GLY A1040
ASP A1041
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
5U3  A1200 ( 4.9A)
None
 0.71A 4xv2A-5f1zA:
20.1		 4xv2A-5f1zA:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 ALA A 928
LYS A 930
GLY A1040
ASP A1041
PHE A1042
 5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
5U3  A1200 ( 4.9A)
None
 0.72A 4xv2B-5f1zA:
26.7		 4xv2B-5f1zA:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ALA A 928
GLY A 984
LEU A1030
GLY A1040
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.69A 5aaaA-5f1zA:
28.1		 5aaaA-5f1zA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1030
GLY A1040
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.72A 5aabA-5f1zA:
28.0		 5aabA-5f1zA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1030
GLY A1040
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.77A 5aacA-5f1zA:
28.0		 5aacA-5f1zA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
ILE A 960
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.64A 5bvwA-5f1zA:
27.8		 5bvwA-5f1zA:
34.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 VAL A 911
ALA A 928
LYS A 930
GLY A1040
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
None
 0.74A 5cswA-5f1zA:
26.2		 5cswA-5f1zA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 VAL A 911
ALA A 928
LYS A 930
GLY A1040
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
None
 0.81A 5cswB-5f1zA:
26.1		 5cswB-5f1zA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
ILE A 960
TYR A 980
ASP A 988
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
None
None
 1.06A 5hesA-5f1zA:
24.9		 5hesA-5f1zA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
LYS A 930
TYR A 980
ASP A 988
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
None
None
 0.99A 5hesB-5f1zA:
24.6		 5hesB-5f1zA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 ALA A 928
LYS A 930
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 5U3  A1200 (-3.5A)
None
None
None
None
None
5U3  A1200 ( 4.9A)
 1.02A 5hi2A-5f1zA:
25.7		 5hi2A-5f1zA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 GLY A 904
VAL A 911
ALA A 928
LYS A 930
GLY A1040
ASP A1041
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.9A)
5U3  A1200 ( 4.9A)
 0.70A 5hieC-5f1zA:
26.8		 5hieC-5f1zA:
29.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
GLU A 947
ILE A 960
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.63A 5i9xA-5f1zA:
27.8		 5i9xA-5f1zA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.63A 5i9yA-5f1zA:
22.3		 5i9yA-5f1zA:
31.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.40A 5lvnA-5f1zA:
26.1		 5lvnA-5f1zA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 GLY A 904
VAL A 911
ALA A 928
ILE A 960
MET A 978
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.0A)
 0.26A 5lw1B-5f1zA:
21.0		 5lw1B-5f1zA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 GLY A 904
VAL A 911
ALA A 928
ILE A 960
MET A 978
LEU A1030
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.4A)
 1.46A 5lw1E-5f1zA:
20.8		 5lw1E-5f1zA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 GLY A 904
VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
 0.76A 5mafA-5f1zA:
24.9		 5mafA-5f1zA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.4A)
 0.57A 5n3hA-5f1zA:
24.3		 5n3hA-5f1zA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 ARG A 901
LEU A 903
GLY A 904
VAL A 911
ALA A 928
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
 0.46A 5xv7A-5f1zA:
22.6		 5xv7A-5f1zA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 1.20A 5y7zA-5f1zA:
23.3		 5y7zA-5f1zA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 1.20A 5y7zA-5f1zA:
23.3		 5y7zA-5f1zA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.85A 5y7zB-5f1zA:
23.3		 5y7zB-5f1zA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.85A 5y80A-5f1zA:
22.7		 5y80A-5f1zA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 903
VAL A 911
LYS A 930
ILE A 960
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.9A)
 0.93A 5yf9X-5f1zA:
23.3		 5yf9X-5f1zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
LYS A 930
MET A 978
ASP A 988
ARG A1027
ASP A1041
 5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
 1.32A 5yu9C-5f1zA:
28.3		 5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
MET A 978
GLY A 984
ASP A 988
ARG A1027
ASP A1041
 5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-3.2A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
 1.16A 5yu9C-5f1zA:
28.3		 5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
GLY A 984
ASP A 988
ARG A1027
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
 1.05A 5yu9C-5f1zA:
28.3		 5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
LYS A 930
ASP A 988
ARG A1027
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
 1.21A 5yu9C-5f1zA:
28.3		 5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
LEU A 976
GLY A 984
ASP A 988
ARG A1027
ASP A1041
 5U3  A1200 ( 4.4A)
None
5U3  A1200 (-3.2A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
 1.37A 5yu9C-5f1zA:
28.3		 5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
GLY A 984
ASP A 988
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.88A 5yu9D-5f1zA:
28.4		 5yu9D-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 7 VAL A 911
LYS A 930
ILE A 960
ASP A1041
 5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.9A)
 0.61A 5ywmX-5f1zA:
23.4		 5ywmX-5f1zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
 0.55A 5zv2A-5f1zA:
28.6		 5zv2A-5f1zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
 0.67A 5zv2B-5f1zA:
28.5		 5zv2B-5f1zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 VAL A 911
ALA A 928
LYS A 930
GLU A 947
ILE A 960
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.70A 6bsdA-5f1zA:
27.4		 6bsdA-5f1zA:
13.70