SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5TR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	5 / 10	TYR A 218 ILE A 326 PHE A 318 LEU A 169 LEU A 173	None MPG A 612 ( 4.7A) None 5TR A 681 ( 4.3A) None	1.40A	2w98A-5f15A: undetectable	2w98A-5f15A: 18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KR4_C_AICC401_1 (OUTER MEMBRANE PROTEIN F)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 8	ARG A 58 TYR A 82 ASP A 158 ARG A 270	None None None 5TR A 681 (-3.5A)	1.32A	4kr4C-5f15A: undetectable	4kr4C-5f15A: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_A_SORA1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 7	LYS A 203 ARG A 270 ASP A 158 TYR A 345	5TR A 681 (-4.0A) 5TR A 681 (-3.5A) None 5TR A 681 (-4.5A)	1.45A	5a06A-5f15A: undetectable	5a06A-5f15A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_C_SORC1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 7	LYS A 203 ARG A 270 ASP A 158 TYR A 345	5TR A 681 (-4.0A) 5TR A 681 (-3.5A) None 5TR A 681 (-4.5A)	1.47A	5a06C-5f15A: 2.4	5a06C-5f15A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_D_SORD1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 7	LYS A 203 ARG A 270 ASP A 158 TYR A 345	5TR A 681 (-4.0A) 5TR A 681 (-3.5A) None 5TR A 681 (-4.5A)	1.47A	5a06D-5f15A: 2.3	5a06D-5f15A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_E_SORE1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 7	LYS A 203 ARG A 270 ASP A 158 TYR A 345	5TR A 681 (-4.0A) 5TR A 681 (-3.5A) None 5TR A 681 (-4.5A)	1.47A	5a06E-5f15A: 2.3	5a06E-5f15A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_F_SORF1343_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 7	LYS A 203 ARG A 270 ASP A 158 TYR A 345	5TR A 681 (-4.0A) 5TR A 681 (-3.5A) None 5TR A 681 (-4.5A)	1.46A	5a06F-5f15A: 2.4	5a06F-5f15A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_P_BEZP801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 6	PHE A 171 SER A 122 ALA A 125 LEU A 169	MPG A 617 ( 4.5A) None None 5TR A 681 ( 4.3A)	1.19A	5dzkB-5f15A: undetectable 5dzkP-5f15A: undetectable	5dzkB-5f15A: 16.67 5dzkP-5f15A: 1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_R_BEZR801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 7	PHE A 171 SER A 122 ALA A 125 LEU A 169	MPG A 617 ( 4.5A) None None 5TR A 681 ( 4.3A)	1.15A	5dzkD-5f15A: undetectable 5dzkR-5f15A: undetectable	5dzkD-5f15A: 16.67 5dzkR-5f15A: 1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_T_BEZT801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 8	PHE A 171 SER A 122 ALA A 125 LEU A 169	MPG A 617 ( 4.5A) None None 5TR A 681 ( 4.3A)	1.06A	5dzkF-5f15A: undetectable 5dzkT-5f15A: undetectable	5dzkF-5f15A: 16.67 5dzkT-5f15A: 1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_U_BEZU801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5f15	4-AMINO-4-DEOXY-L-AR ABINOSE (L-ARA4N) TRANSFERASE (Cupriavidus metallidurans)	4 / 6	PHE A 171 SER A 122 ALA A 125 LEU A 169	MPG A 617 ( 4.5A) None None 5TR A 681 ( 4.3A)	1.06A	5dzkg-5f15A: undetectable 5dzku-5f15A: undetectable	5dzkg-5f15A: 16.67 5dzku-5f15A: 1.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W98_A_P1ZA1351_1","PROSTAGLANDIN REDUCTASE 2","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",5,"TYR A 218;ILE A 326;PHE A 318;LEU A 169;LEU A 173","None;MPG A 612 ( 4.7A);None;5TR A 681 ( 4.3A);None","1.40A","2w98A-5f15A:undetectable",null],["4KR4_C_AICC401_1","OUTER MEMBRANE PROTEIN F","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"ARG A  58;TYR A  82;ASP A 158;ARG A 270","None;None;None;5TR A 681 (-3.5A)","1.32A","4kr4C-5f15A:undetectable","2w98A-5f15A:18.24"],["5A06_A_SORA1341_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"LYS A 203;ARG A 270;ASP A 158;TYR A 345","5TR A 681 (-4.0A);5TR A 681 (-3.5A);None;5TR A 681 (-4.5A)","1.45A","5a06A-5f15A:undetectable","4kr4C-5f15A:19.38"],["5A06_C_SORC1341_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"LYS A 203;ARG A 270;ASP A 158;TYR A 345","5TR A 681 (-4.0A);5TR A 681 (-3.5A);None;5TR A 681 (-4.5A)","1.47A","5a06C-5f15A:2.4","5a06A-5f15A:21.98"],["5A06_D_SORD1342_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"LYS A 203;ARG A 270;ASP A 158;TYR A 345","5TR A 681 (-4.0A);5TR A 681 (-3.5A);None;5TR A 681 (-4.5A)","1.47A","5a06D-5f15A:2.3","5a06C-5f15A:21.98"],["5A06_E_SORE1342_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"LYS A 203;ARG A 270;ASP A 158;TYR A 345","5TR A 681 (-4.0A);5TR A 681 (-3.5A);None;5TR A 681 (-4.5A)","1.47A","5a06E-5f15A:2.3","5a06D-5f15A:21.98"],["5A06_F_SORF1343_0","ALDOSE-ALDOSE OXIDOREDUCTASE","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"LYS A 203;ARG A 270;ASP A 158;TYR A 345","5TR A 681 (-4.0A);5TR A 681 (-3.5A);None;5TR A 681 (-4.5A)","1.46A","5a06F-5f15A:2.4","5a06E-5f15A:21.98"],["5DZK_P_BEZP801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"PHE A 171;SER A 122;ALA A 125;LEU A 169","MPG A 617 ( 4.5A);None;None;5TR A 681 ( 4.3A)","1.19A","5dzkB-5f15A:undetectable;5dzkP-5f15A:undetectable","5a06F-5f15A:21.98"],["5DZK_R_BEZR801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"PHE A 171;SER A 122;ALA A 125;LEU A 169","MPG A 617 ( 4.5A);None;None;5TR A 681 ( 4.3A)","1.15A","5dzkD-5f15A:undetectable;5dzkR-5f15A:undetectable","5dzkB-5f15A:16.67;5dzkP-5f15A:1.67"],["5DZK_T_BEZT801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"PHE A 171;SER A 122;ALA A 125;LEU A 169","MPG A 617 ( 4.5A);None;None;5TR A 681 ( 4.3A)","1.06A","5dzkF-5f15A:undetectable;5dzkT-5f15A:undetectable","5dzkD-5f15A:16.67;5dzkR-5f15A:1.67"],["5DZK_U_BEZU801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5f15","4-AMINO-4-DEOXY-L-ARABINOSE (L-ARA4N) TRANSFERASE","Cupriavidus metallidurans",4,"PHE A 171;SER A 122;ALA A 125;LEU A 169","MPG A 617 ( 4.5A);None;None;5TR A 681 ( 4.3A)","1.06A","5dzkg-5f15A:undetectable;5dzku-5f15A:undetectable","5dzkF-5f15A:16.67;5dzkT-5f15A:1.67"]]