SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5SV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 347
PHE A 442
ILE A 480
LEU A 478
GLY A 344
 None
None
5SV  A 701 (-3.6A)
None
5SV  A 701 (-3.6A)
 1.29A 2e7fB-5ey8A:
undetectable		 2e7fB-5ey8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 GLU A 346
PHE A 441
ILE A 479
LEU A 477
GLY A 343
 None
None
5SV  A 701 (-4.0A)
None
5SV  A 701 (-3.8A)
 1.31A 2e7fB-5ey9A:
undetectable		 2e7fB-5ey9A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 347
PHE A 442
ILE A 480
LEU A 478
GLY A 344
 None
None
5SV  A 701 (-3.6A)
None
5SV  A 701 (-3.6A)
 1.33A 2ogyB-5ey8A:
undetectable		 2ogyB-5ey8A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 GLU A 346
PHE A 441
ILE A 479
LEU A 477
GLY A 343
 None
None
5SV  A 701 (-4.0A)
None
5SV  A 701 (-3.8A)
 1.36A 2ogyB-5ey9A:
undetectable		 2ogyB-5ey9A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 TYR A 342
PRO A 281
ALA A 284
ALA A 345
THR A 186
 5SV  A 701 (-4.8A)
None
None
5SV  A 701 (-4.7A)
None
 1.23A 2x2nA-5ey9A:
undetectable		 2x2nA-5ey9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 GLY A 233
LEU A 310
PHE A 249
SER A 224
LEU A 266
 None
5SV  A 701 (-3.9A)
None
None
None
 1.38A 3bxoA-5ey9A:
undetectable		 3bxoA-5ey9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 227
HIS A 231
MET A 233
 None
5SV  A 701 (-4.0A)
5SV  A 701 ( 3.7A)
 0.90A 3thrD-5ey8A:
2.1		 3thrD-5ey8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		3 / 3 LEU A 226
HIS A 230
MET A 232
 None
5SV  A 701 (-3.9A)
5SV  A 701 (-3.6A)
 0.93A 3thrD-5ey9A:
undetectable		 3thrD-5ey9A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 10 TYR A 472
VAL A 394
SER A 352
TYR A 342
ILE A 419
 None
GOL  A 702 ( 4.8A)
None
5SV  A 701 (-4.8A)
None
 1.35A 3vriA-5ey9A:
undetectable
3vriC-5ey9A:
undetectable		 3vriA-5ey9A:
17.14
3vriC-5ey9A:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 347
PHE A 442
ILE A 480
LEU A 478
GLY A 344
 None
None
5SV  A 701 (-3.6A)
None
5SV  A 701 (-3.6A)
 1.27A 4djfB-5ey8A:
undetectable		 4djfB-5ey8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 GLU A 346
PHE A 441
ILE A 479
LEU A 477
GLY A 343
 None
None
5SV  A 701 (-4.0A)
None
5SV  A 701 (-3.8A)
 1.30A 4djfB-5ey9A:
undetectable		 4djfB-5ey9A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		4 / 6 ASN A 311
ALA A 279
THR A 236
LEU A 349
 None
5SV  A 701 ( 3.7A)
5SV  A 701 ( 3.7A)
5SV  A 701 (-4.6A)
 0.96A 4ejgD-5ey9A:
undetectable		 4ejgD-5ey9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		4 / 8 ILE A 601
ARG A 603
PRO A 227
MET A 232
 None
None
None
5SV  A 701 (-3.6A)
 1.13A 4f4dB-5ey9A:
4.0		 4f4dB-5ey9A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 ASN A 311
GLY A 343
ILE A 419
GLY A 467
SER A 313
 None
5SV  A 701 (-3.8A)
None
None
5SV  A 701 (-4.6A)
 1.21A 4obwC-5ey9A:
undetectable		 4obwC-5ey9A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 401
GLY A 396
GLN A 210
ALA A 346
GLY A 344
 None
None
None
5SV  A 701 (-4.7A)
5SV  A 701 (-3.6A)
 1.09A 4r29A-5ey8A:
undetectable		 4r29A-5ey8A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 ALA A 400
GLY A 395
GLN A 209
ALA A 345
GLY A 343
 None
None
None
5SV  A 701 (-4.7A)
5SV  A 701 (-3.8A)
 1.20A 4r29A-5ey9A:
undetectable		 4r29A-5ey9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 401
GLY A 396
GLN A 210
ALA A 346
GLY A 344
 None
None
None
5SV  A 701 (-4.7A)
5SV  A 701 (-3.6A)
 1.10A 4r29D-5ey8A:
undetectable		 4r29D-5ey8A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 267
LEU A 311
THR A 237
GLN A  86
 None
5SV  A 701 (-4.2A)
5SV  A 701 (-3.3A)
None
 1.18A 5hbsA-5ey8A:
undetectable		 5hbsA-5ey8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
None
None
None
5SV  A 701 (-3.6A)
 1.33A 5mzrA-5ey8A:
undetectable		 5mzrA-5ey8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
None
None
None
5SV  A 701 (-3.6A)
 1.33A 5mzrC-5ey8A:
undetectable		 5mzrC-5ey8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5ey8 ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
None
None
None
5SV  A 701 (-3.6A)
 1.34A 5mzrD-5ey8A:
undetectable		 5mzrD-5ey8A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		3 / 3 LYS A 600
LEU A 226
ASP A 231
 5SV  A 701 (-2.6A)
None
5SV  A 701 (-2.9A)
 0.88A 5zv2A-5ey9A:
undetectable		 5zv2A-5ey9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32
(Mycobacterium
marinum) 		5 / 12 TRP A 420
ILE A 483
TYR A 469
ARG A 482
GLY A 481
 None
None
None
5SV  A 701 (-3.9A)
None
 1.47A 6bp4B-5ey9A:
undetectable		 6bp4B-5ey9A:
18.76