SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5SR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 8 CYH C 135
ASP C 137
GLY C 111
GLY C 112
 None
None
5SR  C 402 (-3.4A)
5SR  C 402 (-4.0A)
 0.91A 1ekjA-5exeC:
undetectable
1ekjB-5exeC:
undetectable		 1ekjA-5exeC:
22.36
1ekjB-5exeC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 7 CYH C 135
ASP C 137
GLY C 111
GLY C 112
 None
None
5SR  C 402 (-3.4A)
5SR  C 402 (-4.0A)
 0.85A 1ekjE-5exeC:
undetectable
1ekjF-5exeC:
undetectable		 1ekjE-5exeC:
22.36
1ekjF-5exeC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		4 / 8 CYH C 135
ASP C 137
GLY C 111
GLY C 112
 None
None
5SR  C 402 (-3.4A)
5SR  C 402 (-4.0A)
 0.88A 1ekjE-5exeC:
undetectable
1ekjF-5exeC:
undetectable		 1ekjE-5exeC:
22.36
1ekjF-5exeC:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 GLY C 145
THR C 144
GLY A  35
SER A  38
TYR A  33
 None
5SR  C 402 (-3.6A)
None
None
None
 1.25A 1nbiC-5exeC:
2.4		 1nbiC-5exeC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 GLY C 145
THR C 144
GLY A  35
SER A  38
TYR A  33
 None
5SR  C 402 (-3.6A)
None
None
None
 1.26A 1nbiD-5exeC:
2.8		 1nbiD-5exeC:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
(Moorella
thermoacetica) 		4 / 8 ASP A 168
GLY A 360
PHE A 117
ASP A 116
 None
None
None
5SR  C 402 (-3.3A)
 0.92A 2aouA-5exeA:
2.2		 2aouA-5exeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.16A 4feuF-5exeB:
undetectable		 4feuF-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.19A 4fewD-5exeB:
undetectable		 4fewD-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.17A 4fewF-5exeB:
undetectable		 4fewF-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.18A 4gkhB-5exeB:
undetectable		 4gkhB-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.16A 4gkhD-5exeB:
undetectable		 4gkhD-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.18A 4gkiA-5exeB:
undetectable		 4gkiA-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
(Moorella
thermoacetica) 		4 / 8 ASP B  57
ASN C 143
CYH C  52
GLU B 154
 None
5SR  C 402 (-4.4A)
SF4  C 401 ( 2.3A)
None
 1.15A 4gkiC-5exeB:
undetectable		 4gkiC-5exeB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 12 ALA C 113
GLY C 111
SER C 149
GLY C  77
PHE C 133
 None
5SR  C 402 (-3.4A)
None
None
None
 1.26A 4obwA-5exeC:
2.9		 4obwA-5exeC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 GLY C  77
GLY C  78
MET C 124
ILE C  47
GLY C  51
 None
None
None
None
5SR  C 402 (-3.3A)
 0.95A 4qoiA-5exeC:
undetectable
4qoiB-5exeC:
undetectable		 4qoiA-5exeC:
20.86
4qoiB-5exeC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 CYH C 225
GLY C 145
THR C 144
ALA C 142
CYH C  52
 SF4  C 401 (-2.3A)
None
5SR  C 402 (-3.6A)
5SR  C 402 (-3.2A)
SF4  C 401 ( 2.3A)
 1.47A 4qvnH-5exeC:
undetectable
4qvnI-5exeC:
undetectable		 4qvnH-5exeC:
22.49
4qvnI-5exeC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 CYH C 225
GLY C 145
THR C 144
ALA C 142
CYH C  52
 SF4  C 401 (-2.3A)
None
5SR  C 402 (-3.6A)
5SR  C 402 (-3.2A)
SF4  C 401 ( 2.3A)
 1.46A 4qvqH-5exeC:
undetectable
4qvqI-5exeC:
undetectable		 4qvqH-5exeC:
22.49
4qvqI-5exeC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 11 CYH C 225
GLY C 145
THR C 144
ALA C 142
CYH C  52
 SF4  C 401 (-2.3A)
None
5SR  C 402 (-3.6A)
5SR  C 402 (-3.2A)
SF4  C 401 ( 2.3A)
 1.47A 4qvqV-5exeC:
undetectable
4qvqW-5exeC:
undetectable		 4qvqV-5exeC:
22.49
4qvqW-5exeC:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica;
Moorella
thermoacetica) 		5 / 12 TYR A  28
GLY C 112
LEU C 121
CYH C 135
ASP C 115
 5SR  C 402 (-4.9A)
5SR  C 402 (-4.0A)
None
None
None
 1.26A 5yniA-5exeA:
undetectable		 5yniA-5exeA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA
(Moorella
thermoacetica) 		5 / 9 VAL C 181
GLY C 112
TYR C 218
ASP C 110
GLY C 109
 None
5SR  C 402 (-4.0A)
None
MG  C 403 ( 2.5A)
5SR  C 402 (-3.5A)
 1.30A 5zniA-5exeC:
undetectable		 5zniA-5exeC:
12.97