SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5SP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_K_AG2K7002_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 7	GLU A 40 ARG A 150 LEU A 140 GLY A 94	5SP A 500 (-3.9A) 5SP A 500 (-2.8A) 5SP A 500 ( 4.8A) None	0.87A	1mt1H-3lquA: undetectable 1mt1K-3lquA: undetectable	1mt1H-3lquA: 21.66 1mt1K-3lquA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_D_AG2D7015_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 7	GLU A 40 ARG A 150 LEU A 140 GLY A 94	5SP A 500 (-3.9A) 5SP A 500 (-2.8A) 5SP A 500 ( 4.8A) None	0.81A	1n13D-3lquA: undetectable 1n13E-3lquA: undetectable	1n13D-3lquA: 21.66 1n13E-3lquA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_F_AG2F7016_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 8	LEU A 140 GLY A 94 GLU A 40 ARG A 150	5SP A 500 ( 4.8A) None 5SP A 500 (-3.9A) 5SP A 500 (-2.8A)	0.80A	1n13A-3lquA: undetectable 1n13F-3lquA: undetectable	1n13A-3lquA: 13.36 1n13F-3lquA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_H_AG2H7012_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 6	GLU A 40 ARG A 150 LEU A 140 GLY A 94	5SP A 500 (-3.9A) 5SP A 500 (-2.8A) 5SP A 500 ( 4.8A) None	0.81A	1n13H-3lquA: undetectable 1n13K-3lquA: undetectable	1n13H-3lquA: 21.66 1n13K-3lquA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_J_AG2J7013_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 7	LEU A 140 GLY A 94 GLU A 40 ARG A 150	5SP A 500 ( 4.8A) None 5SP A 500 (-3.9A) 5SP A 500 (-2.8A)	0.80A	1n13G-3lquA: undetectable 1n13J-3lquA: undetectable	1n13G-3lquA: 13.36 1n13J-3lquA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQD_B_AG2B671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 8	GLU A 40 ARG A 150 LEU A 140 GLY A 94	5SP A 500 (-3.9A) 5SP A 500 (-2.8A) 5SP A 500 ( 4.8A) None	0.87A	2qqdB-3lquA: undetectable 2qqdC-3lquA: undetectable	2qqdB-3lquA: 21.66 2qqdC-3lquA: 27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_C_KANC301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 8	ASP A 42 CYH A 188 GLU A 187 ASP A 33	5SP A 500 ( 3.8A) None None None	1.21A	4gkiC-3lquA: undetectable	4gkiC-3lquA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF0_A_SAMA505_1 (CARNOSINE N-METHYLTRANSFERASE)	3lqu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Salmonella enterica)	4 / 5	GLN A 143 ARG A 150 GLU A 72 ASP A 79	None 5SP A 500 (-2.8A) None None	1.01A	5yf0A-3lquA: undetectable	5yf0A-3lquA: 21.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MT1_K_AG2K7002_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"GLU A  40;ARG A 150;LEU A 140;GLY A  94","5SP A 500 (-3.9A);5SP A 500 (-2.8A);5SP A 500 ( 4.8A);None","0.87A","1mt1H-3lquA:undetectable;1mt1K-3lquA:undetectable",null],["1N13_D_AG2D7015_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"GLU A  40;ARG A 150;LEU A 140;GLY A  94","5SP A 500 (-3.9A);5SP A 500 (-2.8A);5SP A 500 ( 4.8A);None","0.81A","1n13D-3lquA:undetectable;1n13E-3lquA:undetectable","1mt1H-3lquA:21.66;1mt1K-3lquA:13.36"],["1N13_F_AG2F7016_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"LEU A 140;GLY A  94;GLU A  40;ARG A 150","5SP A 500 ( 4.8A);None;5SP A 500 (-3.9A);5SP A 500 (-2.8A)","0.80A","1n13A-3lquA:undetectable;1n13F-3lquA:undetectable","1n13D-3lquA:21.66;1n13E-3lquA:13.36"],["1N13_H_AG2H7012_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"GLU A  40;ARG A 150;LEU A 140;GLY A  94","5SP A 500 (-3.9A);5SP A 500 (-2.8A);5SP A 500 ( 4.8A);None","0.81A","1n13H-3lquA:undetectable;1n13K-3lquA:undetectable","1n13A-3lquA:13.36;1n13F-3lquA:21.66"],["1N13_J_AG2J7013_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"LEU A 140;GLY A  94;GLU A  40;ARG A 150","5SP A 500 ( 4.8A);None;5SP A 500 (-3.9A);5SP A 500 (-2.8A)","0.80A","1n13G-3lquA:undetectable;1n13J-3lquA:undetectable","1n13H-3lquA:21.66;1n13K-3lquA:13.36"],["2QQD_B_AG2B671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"GLU A  40;ARG A 150;LEU A 140;GLY A  94","5SP A 500 (-3.9A);5SP A 500 (-2.8A);5SP A 500 ( 4.8A);None","0.87A","2qqdB-3lquA:undetectable;2qqdC-3lquA:undetectable","1n13G-3lquA:13.36;1n13J-3lquA:21.66"],["4GKI_C_KANC301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"ASP A  42;CYH A 188;GLU A 187;ASP A  33","5SP A 500 ( 3.8A);None;None;None","1.21A","4gkiC-3lquA:undetectable","2qqdB-3lquA:21.66;2qqdC-3lquA:27.43"],["5YF0_A_SAMA505_1","CARNOSINE N-METHYLTRANSFERASE","3lqu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Salmonella enterica",4,"GLN A 143;ARG A 150;GLU A  72;ASP A  79","None;5SP A 500 (-2.8A);None;None","1.01A","5yf0A-3lquA:undetectable","4gkiC-3lquA:21.43"]]