SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5RX'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZBU_A_ADNA501_1 (UNCHARACTERIZED CONSERVED PROTEIN)	5ets	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Staphylococcus aureus)	4 / 4	PHE B 123 ASN B 56 PHE B 54 ASN B 53	5RX B 202 (-3.3A) 5RX B 202 (-3.2A) 5RX B 202 (-3.4A) None	1.35A	2zbuA-5etsB: 0.0	2zbuA-5etsB: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZBU_C_ADNC503_1 (UNCHARACTERIZED CONSERVED PROTEIN)	5ets	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Staphylococcus aureus)	4 / 4	PHE B 123 ASN B 56 PHE B 54 ASN B 53	5RX B 202 (-3.3A) 5RX B 202 (-3.2A) 5RX B 202 (-3.4A) None	1.39A	2zbuC-5etsB: 0.0	2zbuC-5etsB: 19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE)	5ets	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Staphylococcus aureus)	5 / 8	GLY B 9 THR B 43 ASN B 56 ARG B 92 PHE B 123	5RX B 202 ( 4.4A) 5RX B 202 (-3.8A) 5RX B 202 (-3.2A) APC B 201 ( 3.1A) 5RX B 202 (-3.3A)	0.45A	4m5mA-5etsB: 26.4	4m5mA-5etsB: 40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1431_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	5ets	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Staphylococcus aureus)	4 / 7	ASN B 11 ASP B 97 GLY B 7 ASN B 56	5RX B 202 (-3.8A) MG B 204 (-2.5A) None 5RX B 202 (-3.2A)	1.06A	5x7pA-5etsB: undetectable	5x7pA-5etsB: 9.04

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZBU_A_ADNA501_1","UNCHARACTERIZED CONSERVED PROTEIN","5ets","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Staphylococcus aureus",4,"PHE B 123;ASN B  56;PHE B  54;ASN B  53","5RX B 202 (-3.3A);5RX B 202 (-3.2A);5RX B 202 (-3.4A);None","1.35A","2zbuA-5etsB:0.0",null],["2ZBU_C_ADNC503_1","UNCHARACTERIZED CONSERVED PROTEIN","5ets","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Staphylococcus aureus",4,"PHE B 123;ASN B  56;PHE B  54;ASN B  53","5RX B 202 (-3.3A);5RX B 202 (-3.2A);5RX B 202 (-3.4A);None","1.39A","2zbuC-5etsB:0.0","2zbuA-5etsB:19.07"],["4M5M_A_DX4A401_0","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","5ets","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Staphylococcus aureus",5,"GLY B   9;THR B  43;ASN B  56;ARG B  92;PHE B 123","5RX B 202 ( 4.4A);5RX B 202 (-3.8A);5RX B 202 (-3.2A);APC B 201 ( 3.1A);5RX B 202 (-3.3A)","0.45A","4m5mA-5etsB:26.4","2zbuC-5etsB:19.07"],["5X7P_A_ACRA1431_1","GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE","5ets","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Staphylococcus aureus",4,"ASN B  11;ASP B  97;GLY B   7;ASN B  56","5RX B 202 (-3.8A); MG B 204 (-2.5A);None;5RX B 202 (-3.2A)","1.06A","5x7pA-5etsB:undetectable","4m5mA-5etsB:40.00"]]