SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5RP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_A_CCSA417_0 (ESTROGEN RECEPTOR)	2iss	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Thermotoga maritima)	3 / 3	GLU A 90 LYS A 82 VAL A 83	None 5RP A 294 (-1.3A) None	0.97A	1l2iA-2issA: undetectable	1l2iA-2issA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QHY_A_CLMA888_0 (CHLORAMPHENICOL PHOSPHOTRANSFERASE)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	4 / 6	MET A 187 ALA A 193 GLU A 28 GLU A 185	None None None 5RP A 401 (-3.8A)	1.44A	1qhyA-1snnA: undetectable	1qhyA-1snnA: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FXD_A_DR7A102_2 (POL PROTEIN)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	4 / 7	ASP A 107 GLY A 150 ILE A 209 PRO A 111	5RP A 501 (-2.6A) None None None	0.91A	2fxdB-3hheA: undetectable	2fxdB-3hheA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_B_SC2B1294_1 (FICOLIN-2)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 9	VAL A 53 GLY A 105 LEU A 101 ASP A 102 ASP A 104	None 5RP A 501 (-3.5A) None None 5RP A 501 (-4.0A)	1.43A	2j2pB-3hheA: undetectable 2j2pC-3hheA: undetectable	2j2pB-3hheA: 23.85 2j2pC-3hheA: 23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WQ5_A_MIYA1120_1 (PHOSPHOLIPASE A2, ACIDIC)	4ex9	ALNA (Streptomyces sp. CM020)	4 / 7	LEU A 224 ALA A 158 GLY A 127 PHE A 146	None None 5RP A 402 ( 4.2A) None	0.93A	2wq5A-4ex9A: undetectable	2wq5A-4ex9A: 15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_B_SAMB530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 12	ILE A 199 GLY A 176 GLY A 196 LEU A 158 PHE A 185	None 5RP A 501 (-3.7A) 5RP A 501 (-3.6A) None None	1.01A	2y7hB-3exsA: undetectable	2y7hB-3exsA: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_C_SAMC530_0 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 12	ILE A 199 GLY A 176 GLY A 196 LEU A 158 PHE A 185	None 5RP A 501 (-3.7A) 5RP A 501 (-3.6A) None None	1.01A	2y7hC-3exsA: undetectable	2y7hC-3exsA: 17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_C_DHIC8_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	3 / 3	SER A 76 GLY A 48 GLY A 50	None None 5RP A 501 ( 3.9A)	0.51A	3bogA-3hheA: undetectable 3bogC-3hheA: undetectable	3bogA-3hheA: undetectable 3bogC-3hheA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CKK_A_SAMA301_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 12	GLY A 229 GLY A 118 ILE A 156 LEU A 115 GLU A 108	None 5RP A 501 (-3.4A) None None None	1.03A	3ckkA-3hheA: undetectable	3ckkA-3hheA: 23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_A_DR7A100_1 (PROTEASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	6 / 11	GLY A 105 ALA A 106 ASP A 107 LEU A 234 PRO A 252 ILE A 109	5RP A 501 (-3.5A) None 5RP A 501 (-2.6A) None None None	1.48A	3em4A-3hheA: undetectable	3em4A-3hheA: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_A_DR7A100_2 (PROTEASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 9	ARG A 237 ALA A 106 ASP A 107 LEU A 234 ILE A 109	None None 5RP A 501 (-2.6A) None None	1.14A	3em4B-3hheA: undetectable	3em4B-3hheA: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_V_DR7V100_1 (PROTEASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	6 / 11	ARG A 237 GLY A 105 ALA A 106 ASP A 107 LEU A 234 ILE A 109	None 5RP A 501 (-3.5A) None 5RP A 501 (-2.6A) None None	1.08A	3em4U-3hheA: undetectable	3em4U-3hheA: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_V_DR7V100_1 (PROTEASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	6 / 11	GLY A 105 ALA A 106 ASP A 107 LEU A 234 PRO A 252 ILE A 109	5RP A 501 (-3.5A) None 5RP A 501 (-2.6A) None None None	1.48A	3em4U-3hheA: undetectable	3em4U-3hheA: 23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Y_A_DIFA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 11	LEU A 8 ILE A 194 GLY A 196 ALA A 11 LEU A 12	None 5RP A 501 ( 4.6A) 5RP A 501 (-3.6A) 5RP A 501 (-3.6A) None	1.13A	3n8yA-3exsA: undetectable	3n8yA-3exsA: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Y_A_DIFA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 11	VAL A 31 LEU A 8 ILE A 194 GLY A 196 LEU A 12	None None 5RP A 501 ( 4.6A) 5RP A 501 (-3.6A) None	1.13A	3n8yA-3exsA: undetectable	3n8yA-3exsA: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PHA_B_ACRB701_1 (ALPHA-GLUCOSIDASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 12	ILE A 109 ASP A 203 ILE A 201 ASP A 107 PHE A 152	None None None 5RP A 501 (-2.6A) None	1.48A	3phaB-3hheA: undetectable	3phaB-3hheA: 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PHA_D_ACRD701_1 (ALPHA-GLUCOSIDASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 12	ILE A 109 ASP A 203 ILE A 201 ASP A 107 PHE A 152	None None None 5RP A 501 (-2.6A) None	1.49A	3phaD-3hheA: undetectable	3phaD-3hheA: 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZS_A_SAMA1475_0 (METHYLTRANSFERASE WBDD)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	5 / 12	GLY A 213 ARG A 161 GLU A 166 LEU A 211 HIS A 164	None 5RP A 401 (-3.1A) 5RP A 401 ( 4.5A) None ZN A 402 ( 3.2A)	1.29A	4azsA-1snnA: undetectable	4azsA-1snnA: 16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB6_C_VLBC503_1 (TUBULIN BETA CHAIN TUBULIN ALPHA CHAIN)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 12	ASP A 32 THR A 174 ILE A 34 VAL A 31 ILE A 199	None 5RP A 501 (-3.7A) None None None	1.42A	4eb6B-3exsA: undetectable 4eb6C-3exsA: undetectable	4eb6B-3exsA: 18.43 4eb6C-3exsA: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJ1_B_FOLB201_0 (DIHYDROFOLATE REDUCTASE)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	5 / 12	ILE A 216 ALA A 7 LEU A 18 THR A 181 ILE A 183	None None None None 5RP A 401 (-4.9A)	0.96A	4ej1B-1snnA: undetectable	4ej1B-1snnA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I13_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	3 / 3	ASP A 64 ARG A 144 THR A 87	5RP A 501 ( 4.8A) None None	0.89A	4i13A-3exsA: undetectable	4i13A-3exsA: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA501_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	4ex9	ALNA (Streptomyces sp. CM020)	5 / 12	ILE A 110 THR A 109 THR A 288 ASP A 142 ILE A 126	None None None 5RP A 402 (-3.0A) None	1.34A	4i41A-4ex9A: undetectable	4i41A-4ex9A: 23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA2)	2iss	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Thermotoga maritima)	4 / 6	SER A 105 ARG A 148 GLY A 215 GLY A 154	5RP A 294 ( 4.7A) 5RP A 294 (-3.7A) 5RP A 294 (-3.7A) 5RP A 294 (-3.4A)	1.05A	4koeA-2issA: undetectable 4koeB-2issA: undetectable 4koeC-2issA: undetectable	4koeA-2issA: 21.37 4koeB-2issA: 21.37 4koeC-2issA: 27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_B_SAMB301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 12	GLY A 28 LEU A 52 LEU A 55 ALA A 206 GLU A 35	None None None None 5RP A 501 ( 4.7A)	1.13A	4lg1B-3exsA: undetectable	4lg1B-3exsA: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P3Q_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	4 / 5	ASP A 64 ARG A 197 ARG A 144 THR A 87	5RP A 501 ( 4.8A) 5RP A 501 (-3.4A) None None	1.26A	4p3qA-3exsA: undetectable	4p3qA-3exsA: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_B_SAMB301_0 (UNCHARACTERIZED PROTEIN)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 12	ALA A 130 SER A 133 GLY A 46 ALA A 140 GLY A 105	None None None None 5RP A 501 (-3.5A)	1.29A	4r29B-3hheA: undetectable	4r29B-3hheA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X5J_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	5 / 12	ILE A 216 ALA A 7 LEU A 18 THR A 181 ILE A 183	None None None None 5RP A 401 (-4.9A)	0.95A	4x5jA-1snnA: undetectable	4x5jA-1snnA: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	2iss	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Thermotoga maritima)	4 / 6	GLY A 215 GLY A 154 SER A 105 ARG A 148	5RP A 294 (-3.7A) 5RP A 294 (-3.4A) 5RP A 294 ( 4.7A) 5RP A 294 (-3.7A)	1.02A	4z53A-2issA: undetectable 4z53B-2issA: undetectable	4z53A-2issA: 19.09 4z53B-2issA: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_H_SAMH301_0 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	2iss	PYRIDOXAL BIOSYNTHESIS LYASE PDXS (Thermotoga maritima)	5 / 12	ALA A 217 GLY A 154 GLY A 156 GLY A 278 GLU A 106	None 5RP A 294 (-3.4A) None None None	0.97A	5c0oH-2issA: undetectable	5c0oH-2issA: 22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW8_C_FK5C201_1 (FK506-BINDING PROTEIN 1)	3exs	RMPD (HEXULOSE-6-PHOSPHAT E SYNTHASE) (Streptococcus mutans)	5 / 10	ASP A 64 VAL A 33 ILE A 34 LEU A 12 ILE A 114	5RP A 501 ( 4.8A) None None None None	1.28A	5hw8C-3exsA: undetectable 5hw8H-3exsA: undetectable	5hw8C-3exsA: 17.65 5hw8H-3exsA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_C_URFC301_1 (BIFUNCTIONAL PROTEIN PYRR)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	3 / 3	ARG A 161 HIS A 164 ARG A 25	5RP A 401 (-3.1A) ZN A 402 ( 3.2A) 5RP A 401 (-2.9A)	1.10A	5iaoC-1snnA: undetectable	5iaoC-1snnA: 23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_C_URFC301_1 (BIFUNCTIONAL PROTEIN PYRR)	4p8e	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Vibrio cholerae)	3 / 3	ARG A 151 HIS A 154 ARG A 38	5RP A 301 (-2.8A) ZN A 302 ( 3.2A) 5RP A 301 (-3.3A)	1.09A	5iaoC-4p8eA: undetectable	5iaoC-4p8eA: 25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_F_URFF301_1 (BIFUNCTIONAL PROTEIN PYRR)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	3 / 3	ARG A 161 HIS A 164 ARG A 25	5RP A 401 (-3.1A) ZN A 402 ( 3.2A) 5RP A 401 (-2.9A)	1.15A	5iaoF-1snnA: undetectable	5iaoF-1snnA: 23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IAO_F_URFF301_1 (BIFUNCTIONAL PROTEIN PYRR)	4p8e	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Vibrio cholerae)	3 / 3	ARG A 151 HIS A 154 ARG A 38	5RP A 301 (-2.8A) ZN A 302 ( 3.2A) 5RP A 301 (-3.3A)	1.14A	5iaoF-4p8eA: undetectable	5iaoF-4p8eA: 25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KB5_A_ADNA401_1 (ADENOSINE KINASE)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	5 / 12	ASP A 107 LEU A 234 GLY A 119 GLY A 118 GLY A 50	5RP A 501 (-2.6A) None 5RP A 501 (-4.0A) 5RP A 501 (-3.4A) 5RP A 501 ( 3.9A)	0.99A	5kb5A-3hheA: undetectable	5kb5A-3hheA: 25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_B_CVIB301_1 (REGULATORY PROTEIN TETR)	3hhe	RIBOSE-5-PHOSPHATE ISOMERASE A (Bartonella henselae)	4 / 8	GLY A 229 ARG A 186 ASP A 203 ASP A 107	None None None 5RP A 501 (-2.6A)	1.03A	5vlmB-3hheA: undetectable	5vlmB-3hheA: 23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WM7_A_ACTA603_0 (SALICYLATE-AMP LIGASE)	2riu	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Candida albicans)	4 / 4	THR A 146 THR A 85 ALA A 86 ARG A 142	5RP A 701 (-3.5A) 5RP A 701 (-3.1A) None 5RP A 701 (-3.2A)	1.50A	5wm7A-2riuA: 0.0	5wm7A-2riuA: 17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A4I_B_TRPB403_0 (TRYPTOPHAN 2,3-DIOXYGENASE)	4p8e	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Vibrio cholerae)	4 / 7	ARG A 151 GLU A 73 THR A 97 PRO A 83	5RP A 301 (-2.8A) None None None	1.03A	6a4iB-4p8eA: undetectable	6a4iB-4p8eA: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRY_A_H8DA2001_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4ex9	ALNA (Streptomyces sp. CM020)	5 / 11	SER A 155 LEU A 32 ALA A 292 PHE A 121 VAL A 106	None None None None 5RP A 402 (-4.0A)	1.36A	6dryA-4ex9A: undetectable	6dryA-4ex9A: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECF_I_DVAI3010_0 (VLM2 DODECADEPSIPEPTIDE)	1snn	3,4-DIHYDROXY-2-BUTA NONE 4-PHOSPHATE SYNTHASE (Methanocaldococc us jannaschii)	3 / 3	PHE A 70 ARG A 161 ALA A 57	None 5RP A 401 (-3.1A) None	0.69A	6ecfB-1snnA: undetectable	6ecfB-1snnA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_A_ACRA602_1 (-)	4ex9	ALNA (Streptomyces sp. CM020)	5 / 12	GLY A 128 GLY A 127 VAL A 106 VAL A 153 GLY A 157	None 5RP A 402 ( 4.2A) 5RP A 402 (-4.0A) None None	1.10A	6gneA-4ex9A: 2.3	6gneA-4ex9A: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_B_ACRB602_1 (-)	4ex9	ALNA (Streptomyces sp. CM020)	5 / 12	GLY A 128 GLY A 127 VAL A 106 VAL A 153 GLY A 157	None 5RP A 402 ( 4.2A) 5RP A 402 (-4.0A) None None	1.10A	6gneB-4ex9A: undetectable	6gneB-4ex9A: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HCO_A_FY5A1003_0 (ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2)	4ex9	ALNA (Streptomyces sp. CM020)	5 / 11	THR A 149 VAL A 153 MET A 151 THR A 105 ILE A 87	None None None 5RP A 402 (-3.9A) None	1.37A	6hcoA-4ex9A: undetectable 6hcoB-4ex9A: undetectable	6hcoA-4ex9A: 20.09 6hcoB-4ex9A: 20.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L2I_A_CCSA417_0","ESTROGEN RECEPTOR","2iss","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Thermotoga maritima",3,"GLU A  90;LYS A  82;VAL A  83","None;5RP A 294 (-1.3A);None","0.97A","1l2iA-2issA:undetectable",null],["1QHY_A_CLMA888_0","CHLORAMPHENICOL PHOSPHOTRANSFERASE","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",4,"MET A 187;ALA A 193;GLU A  28;GLU A 185","None;None;None;5RP A 401 (-3.8A)","1.44A","1qhyA-1snnA:undetectable","1l2iA-2issA:21.32"],["2FXD_A_DR7A102_2","POL PROTEIN;POL PROTEIN","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",4,"ASP A 107;GLY A 150;ILE A 209;PRO A 111","5RP A 501 (-2.6A);None;None;None","0.91A","2fxdB-3hheA:undetectable","1qhyA-1snnA:22.68"],["2J2P_B_SC2B1294_1","FICOLIN-2;FICOLIN-2","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"VAL A  53;GLY A 105;LEU A 101;ASP A 102;ASP A 104","None;5RP A 501 (-3.5A);None;None;5RP A 501 (-4.0A)","1.43A","2j2pB-3hheA:undetectable;2j2pC-3hheA:undetectable","2fxdB-3hheA:18.60"],["2WQ5_A_MIYA1120_1","PHOSPHOLIPASE A2, ACIDIC","4ex9","ALNA","Streptomyces sp. CM020",4,"LEU A 224;ALA A 158;GLY A 127;PHE A 146","None;None;5RP A 402 ( 4.2A);None","0.93A","2wq5A-4ex9A:undetectable","2j2pB-3hheA:23.85;2j2pC-3hheA:23.85"],["2Y7H_B_SAMB530_0","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"ILE A 199;GLY A 176;GLY A 196;LEU A 158;PHE A 185","None;5RP A 501 (-3.7A);5RP A 501 (-3.6A);None;None","1.01A","2y7hB-3exsA:undetectable","2wq5A-4ex9A:15.02"],["2Y7H_C_SAMC530_0","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"ILE A 199;GLY A 176;GLY A 196;LEU A 158;PHE A 185","None;5RP A 501 (-3.7A);5RP A 501 (-3.6A);None;None","1.01A","2y7hC-3exsA:undetectable","2y7hB-3exsA:17.05"],["3BOG_C_DHIC8_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",3,"SER A  76;GLY A  48;GLY A  50","None;None;5RP A 501 ( 3.9A)","0.51A","3bogA-3hheA:undetectable;3bogC-3hheA:undetectable","2y7hC-3exsA:17.05"],["3CKK_A_SAMA301_0","TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"GLY A 229;GLY A 118;ILE A 156;LEU A 115;GLU A 108","None;5RP A 501 (-3.4A);None;None;None","1.03A","3ckkA-3hheA:undetectable","3bogA-3hheA:undetectable;3bogC-3hheA:undetectable"],["3EM4_A_DR7A100_1","PROTEASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",6,"GLY A 105;ALA A 106;ASP A 107;LEU A 234;PRO A 252;ILE A 109","5RP A 501 (-3.5A);None;5RP A 501 (-2.6A);None;None;None","1.48A","3em4A-3hheA:undetectable","3ckkA-3hheA:23.86"],["3EM4_A_DR7A100_2","PROTEASE;PROTEASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"ARG A 237;ALA A 106;ASP A 107;LEU A 234;ILE A 109","None;None;5RP A 501 (-2.6A);None;None","1.14A","3em4B-3hheA:undetectable","3em4A-3hheA:23.64"],["3EM4_V_DR7V100_1","PROTEASE;PROTEASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",6,"ARG A 237;GLY A 105;ALA A 106;ASP A 107;LEU A 234;ILE A 109","None;5RP A 501 (-3.5A);None;5RP A 501 (-2.6A);None;None","1.08A","3em4U-3hheA:undetectable","3em4B-3hheA:23.64"],["3EM4_V_DR7V100_1","PROTEASE;PROTEASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",6,"GLY A 105;ALA A 106;ASP A 107;LEU A 234;PRO A 252;ILE A 109","5RP A 501 (-3.5A);None;5RP A 501 (-2.6A);None;None;None","1.48A","3em4U-3hheA:undetectable","3em4U-3hheA:23.64"],["3N8Y_A_DIFA701_1","PROSTAGLANDIN G\/H SYNTHASE 1","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"LEU A   8;ILE A 194;GLY A 196;ALA A  11;LEU A  12","None;5RP A 501 ( 4.6A);5RP A 501 (-3.6A);5RP A 501 (-3.6A);None","1.13A","3n8yA-3exsA:undetectable","3em4U-3hheA:23.64"],["3N8Y_A_DIFA701_1","PROSTAGLANDIN G\/H SYNTHASE 1","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"VAL A  31;LEU A   8;ILE A 194;GLY A 196;LEU A  12","None;None;5RP A 501 ( 4.6A);5RP A 501 (-3.6A);None","1.13A","3n8yA-3exsA:undetectable","3n8yA-3exsA:16.87"],["3PHA_B_ACRB701_1","ALPHA-GLUCOSIDASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"ILE A 109;ASP A 203;ILE A 201;ASP A 107;PHE A 152","None;None;None;5RP A 501 (-2.6A);None","1.48A","3phaB-3hheA:undetectable","3n8yA-3exsA:16.87"],["3PHA_D_ACRD701_1","ALPHA-GLUCOSIDASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"ILE A 109;ASP A 203;ILE A 201;ASP A 107;PHE A 152","None;None;None;5RP A 501 (-2.6A);None","1.49A","3phaD-3hheA:undetectable","3phaB-3hheA:17.48"],["4AZS_A_SAMA1475_0","METHYLTRANSFERASE WBDD","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",5,"GLY A 213;ARG A 161;GLU A 166;LEU A 211;HIS A 164","None;5RP A 401 (-3.1A);5RP A 401 ( 4.5A);None; ZN A 402 ( 3.2A)","1.29A","4azsA-1snnA:undetectable","3phaD-3hheA:17.48"],["4EB6_C_VLBC503_1","TUBULIN BETA CHAIN;TUBULIN ALPHA CHAIN","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"ASP A  32;THR A 174;ILE A  34;VAL A  31;ILE A 199","None;5RP A 501 (-3.7A);None;None;None","1.42A","4eb6B-3exsA:undetectable;4eb6C-3exsA:undetectable","4azsA-1snnA:16.64"],["4EJ1_B_FOLB201_0","DIHYDROFOLATE REDUCTASE","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",5,"ILE A 216;ALA A   7;LEU A  18;THR A 181;ILE A 183","None;None;None;None;5RP A 401 (-4.9A)","0.96A","4ej1B-1snnA:undetectable","4eb6B-3exsA:18.43;4eb6C-3exsA:19.31"],["4I13_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",3,"ASP A  64;ARG A 144;THR A  87","5RP A 501 ( 4.8A);None;None","0.89A","4i13A-3exsA:undetectable","4ej1B-1snnA:20.18"],["4I41_A_MIXA501_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","4ex9","ALNA","Streptomyces sp. CM020",5,"ILE A 110;THR A 109;THR A 288;ASP A 142;ILE A 126","None;None;None;5RP A 402 (-3.0A);None","1.34A","4i41A-4ex9A:undetectable","4i13A-3exsA:18.55"],["4KOE_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA2","2iss","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Thermotoga maritima",4,"SER A 105;ARG A 148;GLY A 215;GLY A 154","5RP A 294 ( 4.7A);5RP A 294 (-3.7A);5RP A 294 (-3.7A);5RP A 294 (-3.4A)","1.05A","4koeA-2issA:undetectable;4koeB-2issA:undetectable;4koeC-2issA:undetectable","4i41A-4ex9A:23.03"],["4LG1_B_SAMB301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"GLY A  28;LEU A  52;LEU A  55;ALA A 206;GLU A  35","None;None;None;None;5RP A 501 ( 4.7A)","1.13A","4lg1B-3exsA:undetectable","4koeA-2issA:21.37;4koeB-2issA:21.37;4koeC-2issA:27.55"],["4P3Q_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",4,"ASP A  64;ARG A 197;ARG A 144;THR A  87","5RP A 501 ( 4.8A);5RP A 501 (-3.4A);None;None","1.26A","4p3qA-3exsA:undetectable","4lg1B-3exsA:20.58"],["4R29_B_SAMB301_0","UNCHARACTERIZED PROTEIN","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"ALA A 130;SER A 133;GLY A  46;ALA A 140;GLY A 105","None;None;None;None;5RP A 501 (-3.5A)","1.29A","4r29B-3hheA:undetectable","4p3qA-3exsA:18.55"],["4X5J_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",5,"ILE A 216;ALA A   7;LEU A  18;THR A 181;ILE A 183","None;None;None;None;5RP A 401 (-4.9A)","0.95A","4x5jA-1snnA:undetectable","4r29B-3hheA:21.45"],["4Z53_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","2iss","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Thermotoga maritima",4,"GLY A 215;GLY A 154;SER A 105;ARG A 148","5RP A 294 (-3.7A);5RP A 294 (-3.4A);5RP A 294 ( 4.7A);5RP A 294 (-3.7A)","1.02A","4z53A-2issA:undetectable;4z53B-2issA:undetectable","4x5jA-1snnA:19.74"],["5C0O_H_SAMH301_0","TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRMI","2iss","PYRIDOXAL BIOSYNTHESIS LYASE PDXS","Thermotoga maritima",5,"ALA A 217;GLY A 154;GLY A 156;GLY A 278;GLU A 106","None;5RP A 294 (-3.4A);None;None;None","0.97A","5c0oH-2issA:undetectable","4z53A-2issA:19.09;4z53B-2issA:19.09"],["5HW8_C_FK5C201_1","FK506-BINDING PROTEIN 1;FK506-BINDING PROTEIN 1","3exs","RMPD (HEXULOSE-6-PHOSPHATE SYNTHASE)","Streptococcus mutans",5,"ASP A  64;VAL A  33;ILE A  34;LEU A  12;ILE A 114","5RP A 501 ( 4.8A);None;None;None;None","1.28A","5hw8C-3exsA:undetectable;5hw8H-3exsA:undetectable","5c0oH-2issA:22.89"],["5IAO_C_URFC301_1","BIFUNCTIONAL PROTEIN PYRR","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",3,"ARG A 161;HIS A 164;ARG A  25","5RP A 401 (-3.1A); ZN A 402 ( 3.2A);5RP A 401 (-2.9A)","1.10A","5iaoC-1snnA:undetectable","5hw8C-3exsA:17.65;5hw8H-3exsA:17.65"],["5IAO_C_URFC301_1","BIFUNCTIONAL PROTEIN PYRR","4p8e","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Vibrio cholerae",3,"ARG A 151;HIS A 154;ARG A  38","5RP A 301 (-2.8A); ZN A 302 ( 3.2A);5RP A 301 (-3.3A)","1.09A","5iaoC-4p8eA:undetectable","5iaoC-1snnA:23.41"],["5IAO_F_URFF301_1","BIFUNCTIONAL PROTEIN PYRR","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",3,"ARG A 161;HIS A 164;ARG A  25","5RP A 401 (-3.1A); ZN A 402 ( 3.2A);5RP A 401 (-2.9A)","1.15A","5iaoF-1snnA:undetectable","5iaoC-4p8eA:25.59"],["5IAO_F_URFF301_1","BIFUNCTIONAL PROTEIN PYRR","4p8e","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Vibrio cholerae",3,"ARG A 151;HIS A 154;ARG A  38","5RP A 301 (-2.8A); ZN A 302 ( 3.2A);5RP A 301 (-3.3A)","1.14A","5iaoF-4p8eA:undetectable","5iaoF-1snnA:23.41"],["5KB5_A_ADNA401_1","ADENOSINE KINASE","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",5,"ASP A 107;LEU A 234;GLY A 119;GLY A 118;GLY A  50","5RP A 501 (-2.6A);None;5RP A 501 (-4.0A);5RP A 501 (-3.4A);5RP A 501 ( 3.9A)","0.99A","5kb5A-3hheA:undetectable","5iaoF-4p8eA:25.59"],["5VLM_B_CVIB301_1","REGULATORY PROTEIN TETR","3hhe","RIBOSE-5-PHOSPHATE ISOMERASE A","Bartonella henselae",4,"GLY A 229;ARG A 186;ASP A 203;ASP A 107","None;None;None;5RP A 501 (-2.6A)","1.03A","5vlmB-3hheA:undetectable","5kb5A-3hheA:25.34"],["5WM7_A_ACTA603_0","SALICYLATE-AMP LIGASE","2riu","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Candida albicans",4,"THR A 146;THR A  85;ALA A  86;ARG A 142","5RP A 701 (-3.5A);5RP A 701 (-3.1A);None;5RP A 701 (-3.2A)","1.50A","5wm7A-2riuA:0.0","5vlmB-3hheA:23.35"],["6A4I_B_TRPB403_0","TRYPTOPHAN 2,3-DIOXYGENASE","4p8e","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Vibrio cholerae",4,"ARG A 151;GLU A  73;THR A  97;PRO A  83","5RP A 301 (-2.8A);None;None;None","1.03A","6a4iB-4p8eA:undetectable","5wm7A-2riuA:17.17"],["6DRY_A_H8DA2001_0","5HT2B RECEPTOR, BRIL CHIMERA","4ex9","ALNA","Streptomyces sp. CM020",5,"SER A 155;LEU A  32;ALA A 292;PHE A 121;VAL A 106","None;None;None;None;5RP A 402 (-4.0A)","1.36A","6dryA-4ex9A:undetectable","6a4iB-4p8eA:22.76"],["6ECF_I_DVAI3010_0","VLM2;DODECADEPSIPEPTIDE","1snn","3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE","Methanocaldococcus jannaschii",3,"PHE A  70;ARG A 161;ALA A  57","None;5RP A 401 (-3.1A);None","0.69A","6ecfB-1snnA:undetectable","6dryA-4ex9A:21.41"],["6GNE_A_ACRA602_1","-","4ex9","ALNA","Streptomyces sp. CM020",5,"GLY A 128;GLY A 127;VAL A 106;VAL A 153;GLY A 157","None;5RP A 402 ( 4.2A);5RP A 402 (-4.0A);None;None","1.10A","6gneA-4ex9A:2.3","6ecfB-1snnA:20.32"],["6GNE_B_ACRB602_1","-","4ex9","ALNA","Streptomyces sp. CM020",5,"GLY A 128;GLY A 127;VAL A 106;VAL A 153;GLY A 157","None;5RP A 402 ( 4.2A);5RP A 402 (-4.0A);None;None","1.10A","6gneB-4ex9A:undetectable","6gneA-4ex9A:20.54"],["6HCO_A_FY5A1003_0","ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2","4ex9","ALNA","Streptomyces sp. CM020",5,"THR A 149;VAL A 153;MET A 151;THR A 105;ILE A  87","None;None;None;5RP A 402 (-3.9A);None","1.37A","6hcoA-4ex9A:undetectable;6hcoB-4ex9A:undetectable","6gneB-4ex9A:20.54"]]