SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5RC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 GLY A  63
VAL A  70
ALA A  83
VAL A 116
ASN A 183
LEU A 185
ASP A 196
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.1A)
None
5RC  A4000 (-3.6A)
 0.74A 1fmoE-5es1A:
28.2		 1fmoE-5es1A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 9 GLY A  63
VAL A  70
ALA A  83
TYR A 134
ALA A 135
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
 0.57A 1muoA-5es1A:
25.4		 1muoA-5es1A:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
GLU A 103
VAL A 116
GLY A 138
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
 0.90A 1opjB-5es1A:
11.1		 1opjB-5es1A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		4 / 7 ASN A 183
HIS A 176
PHE A 197
ILE A 162
 5RC  A4000 (-4.1A)
None
None
None
 1.31A 1tdnA-5es1A:
undetectable		 1tdnA-5es1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
LYS A  85
VAL A 116
ASN A 183
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.1A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.76A 2eufB-5es1A:
26.1		 2eufB-5es1A:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 11 GLY A  63
VAL A  70
ALA A  83
TYR A 134
ALA A 135
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
 0.57A 2evaA-5es1A:
23.3		 2evaA-5es1A:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
GLU A 103
VAL A 116
GLY A 138
LEU A 185
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
 0.94A 2hyyC-5es1A:
11.0		 2hyyC-5es1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 GLY A  63
VAL A  70
LYS A  85
LEU A 130
TYR A 134
ALA A 135
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
 0.46A 2ivuA-5es1A:
24.6		 2ivuA-5es1A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 GLY A  63
VAL A  70
ALA A  83
TYR A 134
GLY A 138
ASP A 196
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
5RC  A4000 (-3.6A)
 0.74A 2wgjA-5es1A:
9.3		 2wgjA-5es1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 10 ILE A  62
VAL A  70
ALA A  83
GLY A 138
ASP A 142
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-3.3A)
None
None
 0.88A 2y7jC-5es1A:
26.7		 2y7jC-5es1A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 11 VAL A  70
ALA A  83
VAL A 116
TYR A 134
GLY A 138
LEU A 185
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.51A 3g0eA-5es1A:
21.9		 3g0eA-5es1A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 GLY A  63
VAL A  70
ALA A  83
LYS A  85
VAL A 116
TYR A 134
LEU A 185
ALA A 195
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
 0.98A 3lxkA-5es1A:
23.6		 3lxkA-5es1A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
LYS A  85
VAL A 116
MET A 132
TYR A 134
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 ( 3.9A)
 0.75A 3lxkA-5es1A:
23.6		 3lxkA-5es1A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 ALA A  83
GLU A 103
VAL A 116
GLY A 138
HIS A 176
ALA A 195
 5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
 0.92A 3oxzA-5es1A:
22.1		 3oxzA-5es1A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
GLU A 103
TYR A 134
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.83A 3rgfA-5es1A:
6.0		 3rgfA-5es1A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 5 LYS A  85
ILE A 106
VAL A 116
LEU A 185
ASP A 196
 5RC  A4000 (-2.8A)
None
None
None
5RC  A4000 (-3.6A)
 1.17A 3wzdA-5es1A:
9.2		 3wzdA-5es1A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 9 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
None
None
5RC  A4000 (-4.5A)
None
 0.82A 3zosA-5es1A:
22.4		 3zosA-5es1A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 9 ILE A 106
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 None
None
None
5RC  A4000 (-4.5A)
None
 0.83A 3zosB-5es1A:
22.5		 3zosB-5es1A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		4 / 5 VAL A  70
ILE A 115
TYR A 134
ILE A 194
 5RC  A4000 (-4.6A)
None
5RC  A4000 (-4.5A)
None
 0.53A 4c8bA-5es1A:
23.1		 4c8bA-5es1A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ALA A  83
LYS A  85
GLU A 103
ILE A 115
HIS A 176
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
None
None
5RC  A4000 ( 3.9A)
 0.82A 4c8bB-5es1A:
23.0		 4c8bB-5es1A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 10 GLY A  63
GLY A  65
VAL A  70
ALA A  83
TYR A 134
ALA A 135
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
 0.50A 4ckjA-5es1A:
24.8		 4ckjA-5es1A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ALA A  83
GLU A 103
ILE A 106
VAL A 116
TYR A 134
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
None
None
None
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
 1.05A 4csvA-5es1A:
23.7		 4csvA-5es1A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
GLU A 103
ILE A 106
TYR A 134
LEU A 185
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
 0.93A 4csvA-5es1A:
23.7		 4csvA-5es1A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 11 ARG A 295
TYR A 218
GLU A 182
ALA A 181
PRO A 217
 None
None
5RC  A4000 (-4.0A)
None
None
 1.08A 4dmgB-5es1A:
undetectable		 4dmgB-5es1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		4 / 6 LEU A 128
LYS A  85
LEU A 100
GLU A 103
 None
5RC  A4000 (-2.8A)
None
None
 1.14A 4f3tA-5es1A:
undetectable		 4f3tA-5es1A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
ASP A 142
ASP A 178
ASN A 183
LEU A 185
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-4.1A)
None
5RC  A4000 (-3.6A)
 0.66A 4i41A-5es1A:
26.8		 4i41A-5es1A:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 GLY A  63
VAL A  70
ALA A  83
LEU A 118
LEU A 130
GLY A 138
GLU A 139
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
None
 0.70A 4ifgA-5es1A:
24.1		 4ifgA-5es1A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 GLY A  63
VAL A  70
ALA A  83
LYS A  85
LEU A 118
LEU A 130
GLU A 182
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
5RC  A4000 (-4.0A)
 0.80A 4ifgA-5es1A:
24.1		 4ifgA-5es1A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 VAL A  70
ALA A  83
LYS A  85
VAL A 116
MET A 132
TYR A 134
GLY A 138
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
5RC  A4000 (-3.6A)
 0.90A 4mxyA-5es1A:
21.2		 4mxyA-5es1A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 ALA A  83
VAL A 116
MET A 132
TYR A 134
GLY A 138
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.94A 4mxyB-5es1A:
21.2		 4mxyB-5es1A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 VAL A  70
ALA A  83
LYS A  85
VAL A 116
MET A 132
TYR A 134
GLY A 138
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
5RC  A4000 (-3.6A)
 0.90A 4mxzA-5es1A:
21.2		 4mxzA-5es1A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 ALA A  83
VAL A 116
MET A 132
TYR A 134
GLY A 138
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.94A 4mxzB-5es1A:
21.2		 4mxzB-5es1A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 9 ILE A  62
VAL A  70
ALA A  83
ASN A 183
LEU A 185
ASP A 196
 5RC  A4000 (-4.0A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.1A)
None
5RC  A4000 (-3.6A)
 0.90A 4ogrI-5es1A:
25.3		 4ogrI-5es1A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 GLY A  63
GLY A  65
VAL A  70
ALA A  83
LYS A  85
VAL A 116
LEU A 185
ALA A 195
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
5RC  A4000 ( 3.9A)
 0.71A 4otiA-5es1A:
24.6		 4otiA-5es1A:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 VAL A  70
LYS A  85
VAL A 116
TYR A 134
GLY A 138
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 1.01A 4otwA-5es1A:
21.8		 4otwA-5es1A:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ALA A  83
GLU A 103
MET A 132
TYR A 134
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.76A 4qmnA-5es1A:
27.3		 4qmnA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ILE A  62
ALA A  83
GLU A 103
MET A 132
TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.78A 4qmnA-5es1A:
27.3		 4qmnA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ILE A  62
ALA A  83
LYS A  85
GLU A 103
MET A 132
TYR A 134
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
 0.89A 4qmnA-5es1A:
27.3		 4qmnA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 11 ILE A  62
ALA A  83
LYS A  85
GLU A 103
MET A 132
TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.80A 4qmsA-5es1A:
27.4		 4qmsA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ILE A  62
GLY A  63
VAL A  70
ALA A  83
MET A 132
TYR A 134
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 ( 4.0A)
5RC  A4000 (-4.5A)
None
 0.65A 4qmzA-5es1A:
27.2		 4qmzA-5es1A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 ALA A  83
GLU A 103
ALA A 135
HIS A 176
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
None
5RC  A4000 ( 3.9A)
 1.06A 4tyjA-5es1A:
23.2		 4tyjA-5es1A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 ALA A  83
GLU A 103
CYH A 169
HIS A 176
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
None
None
None
None
5RC  A4000 ( 3.9A)
 1.39A 4tyjA-5es1A:
23.2		 4tyjA-5es1A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 10 VAL A  70
GLU A 103
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 5RC  A4000 (-4.6A)
None
None
None
5RC  A4000 (-4.5A)
None
 0.82A 4u0iA-5es1A:
22.5		 4u0iA-5es1A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 10 VAL A  70
LEU A 110
ILE A 115
VAL A 116
TYR A 134
ILE A 194
 5RC  A4000 (-4.6A)
None
None
None
5RC  A4000 (-4.5A)
None
 0.61A 4u0iA-5es1A:
22.5		 4u0iA-5es1A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		9 / 11 GLY A  65
VAL A  70
ALA A  83
TYR A 134
GLY A 138
ASN A 183
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
5RC  A4000 (-4.1A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.85A 4u5jA-5es1A:
25.0		 4u5jA-5es1A:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 12 ALA A  83
GLU A 103
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.82A 4v01A-5es1A:
22.5		 4v01A-5es1A:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 12 ALA A  83
GLU A 103
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.81A 4v01B-5es1A:
22.9		 4v01B-5es1A:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
GLU A 103
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.79A 4v04A-5es1A:
22.4		 4v04A-5es1A:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 VAL A  70
ALA A  83
TYR A 134
ALA A 135
ASP A 142
GLY A 198
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 1.15A 5hesA-5es1A:
7.5		 5hesA-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 VAL A  70
TYR A 134
ALA A 135
ASP A 142
PHE A 197
GLY A 198
 5RC  A4000 (-4.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
None
 1.33A 5hesA-5es1A:
7.5		 5hesA-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
LYS A  85
TYR A 134
ALA A 135
ASP A 142
GLY A 198
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 1.19A 5hesB-5es1A:
22.5		 5hesB-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 VAL A  70
LYS A  85
TYR A 134
ALA A 135
ASP A 142
PHE A 197
 5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 1.07A 5hesB-5es1A:
22.5		 5hesB-5es1A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 ILE A  62
ALA A  83
LYS A  85
TYR A 134
GLY A 138
LEU A 185
 5RC  A4000 (-4.0A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.71A 5i9xA-5es1A:
23.5		 5i9xA-5es1A:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		4 / 7 GLY A  63
GLY A  65
VAL A  70
LYS A  85
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
 0.34A 5izjA-5es1A:
17.7		 5izjA-5es1A:
32.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		5 / 7 GLY A  63
GLY A  65
VAL A  70
LYS A  85
ASP A 196
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-3.6A)
 0.57A 5j5xA-5es1A:
28.4		 5j5xA-5es1A:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 GLY A  63
VAL A  70
ALA A  83
VAL A 116
LEU A 185
ALA A 195
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
None
5RC  A4000 ( 3.9A)
 0.65A 5l2iA-5es1A:
8.0		 5l2iA-5es1A:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 11 GLY A  63
VAL A  70
ALA A  83
VAL A 116
ALA A 135
GLU A 139
GLU A 182
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 (-4.0A)
None
 0.60A 5lvnA-5es1A:
29.6		 5lvnA-5es1A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 11 GLY A  63
VAL A  70
ALA A  83
VAL A 116
TYR A 134
ALA A 135
GLU A 139
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 0.50A 5lvnA-5es1A:
29.6		 5lvnA-5es1A:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 ILE A  62
GLY A  63
VAL A  70
ALA A  83
LYS A  85
GLU A 103
TYR A 134
 5RC  A4000 (-4.0A)
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
 0.65A 5mafA-5es1A:
37.1		 5mafA-5es1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		8 / 12 ILE A  62
GLY A  63
VAL A  70
ALA A  83
LYS A  85
TYR A 134
GLY A 138
GLU A 139
 5RC  A4000 (-4.0A)
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.72A 5mafA-5es1A:
37.1		 5mafA-5es1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		4 / 8 ALA A  83
GLU A 103
LEU A 185
ASP A 196
 5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.6A)
 0.72A 5owrA-5es1A:
22.7		 5owrA-5es1A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		6 / 12 LEU A  72
ALA A  83
GLU A 103
VAL A 116
GLY A 138
LEU A 185
 None
5RC  A4000 (-3.6A)
None
None
5RC  A4000 (-3.3A)
None
 0.62A 5te0A-5es1A:
27.3		 5te0A-5es1A:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
GLU A 103
TYR A 134
ALA A 135
GLY A 138
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
 0.87A 5zv2A-5es1A:
22.4		 5zv2A-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
LYS A  85
GLU A 103
ALA A 135
GLY A 138
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-3.7A)
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
 0.76A 5zv2B-5es1A:
22.8		 5zv2B-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		3 / 3 TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.89A 5zv2B-5es1A:
22.8		 5zv2B-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
LYS A  85
GLU A 103
TYR A 134
GLY A 138
LEU A 185
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.72A 6bsdA-5es1A:
22.0		 6bsdA-5es1A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens) 		7 / 12 VAL A  70
ALA A  83
LYS A  85
GLU A 103
VAL A 116
LEU A 185
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
None
5RC  A4000 ( 3.9A)
 1.07A 6hd4A-5es1A:
17.0		 6hd4A-5es1A:
14.51