SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5PL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_D_DCFD1853_2 (ADENOSINE DEAMINASE)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	4 / 4	HIS A 739 LEU A 217 LEU A 161 LEU A 565	5PL A 900 ( 4.8A) 5PL A 900 ( 4.9A) None None	1.23A	1a4lD-2yevA: undetectable	1a4lD-2yevA: 17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SDU_B_MK1B902_1 (PROTEASE RETROPEPSIN)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 11	ILE A 742 GLY A 743 GLY A 744 ILE A 697 VAL A 594	5PL A 900 (-4.3A) None None None None	0.99A	1sduA-2yevA: undetectable	1sduA-2yevA: 7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UA1_A_08YA600_1 (CYTOCHROME P450 3A4)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 12	PHE A 624 PHE A 165 THR A 213 PHE A 589 ALA A 590	5PL A 900 (-3.7A) 5PL A 900 (-4.1A) None None 5PL A 900 ( 3.9A)	1.21A	3ua1A-2yevA: 0.0	3ua1A-2yevA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FE1_A_PQNA846_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 10	PHE A 165 ALA A 158 LEU A 161 GLY A 164 ALA A 728	5PL A 900 (-4.1A) None None None None	1.27A	4fe1A-2yevA: 0.0 4fe1J-2yevA: undetectable	4fe1A-2yevA: 24.18 4fe1J-2yevA: 4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y28_A_PQNA5001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 9	PHE A 165 ALA A 158 LEU A 161 GLY A 164 PHE A 711	5PL A 900 (-4.1A) None None None None	1.40A	4y28A-2yevA: 4.6 4y28J-2yevA: 0.0	4y28A-2yevA: 23.35 4y28J-2yevA: 5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_C_REAC602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 10	THR A 731 LEU A 217 PHE A 165 LEU A 631 LEU A 635	None 5PL A 900 ( 4.9A) 5PL A 900 (-4.1A) None None	1.18A	5fhzC-2yevA: undetectable	5fhzC-2yevA: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCG_A_08YA602_1 (CYTOCHROME P450 3A4)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 12	PHE A 624 PHE A 165 THR A 213 PHE A 589 ALA A 590	5PL A 900 (-3.7A) 5PL A 900 (-4.1A) None None 5PL A 900 ( 3.9A)	1.21A	5vcgA-2yevA: undetectable	5vcgA-2yevA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2yev	CYTOCHROME C OXIDASE POLYPEPTIDE I+III (Thermus thermophilus)	5 / 12	ALA A 754 PHE A 589 THR A 766 LEU A 767 ALA A 770	None None 5PL A 900 (-2.8A) None 5PL A 900 ( 4.3A)	1.00A	6djzC-2yevA: undetectable	6djzC-2yevA: 15.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A4L_D_DCFD1853_2","ADENOSINE DEAMINASE","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",4,"HIS A 739;LEU A 217;LEU A 161;LEU A 565","5PL A 900 ( 4.8A);5PL A 900 ( 4.9A);None;None","1.23A","1a4lD-2yevA:undetectable",null],["1SDU_B_MK1B902_1","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"ILE A 742;GLY A 743;GLY A 744;ILE A 697;VAL A 594","5PL A 900 (-4.3A);None;None;None;None","0.99A","1sduA-2yevA:undetectable","1a4lD-2yevA:17.02"],["3UA1_A_08YA600_1","CYTOCHROME P450 3A4","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"PHE A 624;PHE A 165;THR A 213;PHE A 589;ALA A 590","5PL A 900 (-3.7A);5PL A 900 (-4.1A);None;None;5PL A 900 ( 3.9A)","1.21A","3ua1A-2yevA:0.0","1sduA-2yevA:7.33"],["4FE1_A_PQNA846_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"PHE A 165;ALA A 158;LEU A 161;GLY A 164;ALA A 728","5PL A 900 (-4.1A);None;None;None;None","1.27A","4fe1A-2yevA:0.0;4fe1J-2yevA:undetectable","3ua1A-2yevA:21.71"],["4Y28_A_PQNA5001_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"PHE A 165;ALA A 158;LEU A 161;GLY A 164;PHE A 711","5PL A 900 (-4.1A);None;None;None;None","1.40A","4y28A-2yevA:4.6;4y28J-2yevA:0.0","4fe1A-2yevA:24.18;4fe1J-2yevA:4.95"],["5FHZ_C_REAC602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"THR A 731;LEU A 217;PHE A 165;LEU A 631;LEU A 635","None;5PL A 900 ( 4.9A);5PL A 900 (-4.1A);None;None","1.18A","5fhzC-2yevA:undetectable","4y28A-2yevA:23.35;4y28J-2yevA:5.07"],["5VCG_A_08YA602_1","CYTOCHROME P450 3A4","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"PHE A 624;PHE A 165;THR A 213;PHE A 589;ALA A 590","5PL A 900 (-3.7A);5PL A 900 (-4.1A);None;None;5PL A 900 ( 3.9A)","1.21A","5vcgA-2yevA:undetectable","5fhzC-2yevA:20.76"],["6DJZ_C_GMJC301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","2yev","CYTOCHROME C OXIDASE POLYPEPTIDE I+III","Thermus thermophilus",5,"ALA A 754;PHE A 589;THR A 766;LEU A 767;ALA A 770","None;None;5PL A 900 (-2.8A);None;5PL A 900 ( 4.3A)","1.00A","6djzC-2yevA:undetectable","5vcgA-2yevA:21.83"]]