SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5OP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LBD_A_REAA500_1 (RETINOIC ACID RECEPTOR GAMMA)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	5 / 12	LEU A 252 ILE A 251 PHE A 229 SER A 161 LEU A 290	None None None None 5OP A 600 (-3.7A)	1.26A	2lbdA-2zb4A: undetectable	2lbdA-2zb4A: 20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	7 / 10	TYR A 51 ILE A 65 TYR A 259 TYR A 265 LEU A 288 VAL A 289 LEU A 290	5OP A 600 (-3.4A) 5OP A 600 ( 4.6A) NAP A 500 (-4.4A) None NAP A 500 (-4.7A) NAP A 500 ( 3.6A) 5OP A 600 (-3.7A)	0.87A	2w98A-2zb4A: 57.6	2w98A-2zb4A: 97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	5 / 8	TYR A 51 ILE A 65 TYR A 259 TYR A 265 LEU A 288	5OP A 600 (-3.4A) 5OP A 600 ( 4.6A) NAP A 500 (-4.4A) None NAP A 500 (-4.7A)	0.61A	2w98B-2zb4A: 57.9	2w98B-2zb4A: 97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	6 / 8	TYR A 51 TYR A 259 TYR A 265 LEU A 288 VAL A 289 LEU A 290	5OP A 600 (-3.4A) NAP A 500 (-4.4A) None NAP A 500 (-4.7A) NAP A 500 ( 3.6A) 5OP A 600 (-3.7A)	0.52A	2w98B-2zb4A: 57.9	2w98B-2zb4A: 97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ZB7_A_NCAA901_0 (PROSTAGLANDIN REDUCTASE 2)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	5 / 5	TYR A 51 ILE A 65 MET A 135 LEU A 288 LEU A 290	5OP A 600 (-3.4A) 5OP A 600 ( 4.6A) 5OP A 600 ( 2.7A) NAP A 500 (-4.7A) 5OP A 600 (-3.7A)	0.45A	2zb7A-2zb4A: 60.2	2zb7A-2zb4A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ZB8_A_IMNA800_1 (PROSTAGLANDIN REDUCTASE 2)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	8 / 9	TYR A 51 CYH A 54 PHE A 99 TYR A 100 TYR A 259 LEU A 288 VAL A 289 LEU A 290	5OP A 600 (-3.4A) None 5OP A 600 (-4.5A) 5OP A 600 (-4.9A) NAP A 500 (-4.4A) NAP A 500 (-4.7A) NAP A 500 ( 3.6A) 5OP A 600 (-3.7A)	0.59A	2zb8A-2zb4A: 56.8	2zb8A-2zb4A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2ZB8_A_IMNA800_1 (PROSTAGLANDIN REDUCTASE 2)	2zb4	PROSTAGLANDIN REDUCTASE 2 (Homo sapiens)	6 / 9	TYR A 51 CYH A 54 THR A 60 TYR A 259 LEU A 288 VAL A 289	5OP A 600 (-3.4A) None None NAP A 500 (-4.4A) NAP A 500 (-4.7A) NAP A 500 ( 3.6A)	1.01A	2zb8A-2zb4A: 56.8	2zb8A-2zb4A: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2LBD_A_REAA500_1","RETINOIC ACID RECEPTOR GAMMA","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",5,"LEU A 252;ILE A 251;PHE A 229;SER A 161;LEU A 290","None;None;None;None;5OP A 600 (-3.7A)","1.26A","2lbdA-2zb4A:undetectable",null],["2W98_A_P1ZA1351_1","PROSTAGLANDIN REDUCTASE 2","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",7,"TYR A  51;ILE A  65;TYR A 259;TYR A 265;LEU A 288;VAL A 289;LEU A 290","5OP A 600 (-3.4A);5OP A 600 ( 4.6A);NAP A 500 (-4.4A);None;NAP A 500 (-4.7A);NAP A 500 ( 3.6A);5OP A 600 (-3.7A)","0.87A","2w98A-2zb4A:57.6","2lbdA-2zb4A:20.43"],["2W98_B_P1ZB1356_1","PROSTAGLANDIN REDUCTASE 2","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",5,"TYR A  51;ILE A  65;TYR A 259;TYR A 265;LEU A 288","5OP A 600 (-3.4A);5OP A 600 ( 4.6A);NAP A 500 (-4.4A);None;NAP A 500 (-4.7A)","0.61A","2w98B-2zb4A:57.9","2w98A-2zb4A:97.49"],["2W98_B_P1ZB1356_1","PROSTAGLANDIN REDUCTASE 2","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",6,"TYR A  51;TYR A 259;TYR A 265;LEU A 288;VAL A 289;LEU A 290","5OP A 600 (-3.4A);NAP A 500 (-4.4A);None;NAP A 500 (-4.7A);NAP A 500 ( 3.6A);5OP A 600 (-3.7A)","0.52A","2w98B-2zb4A:57.9","2w98B-2zb4A:97.49"],["2ZB7_A_NCAA901_0","PROSTAGLANDIN REDUCTASE 2","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",5,"TYR A  51;ILE A  65;MET A 135;LEU A 288;LEU A 290","5OP A 600 (-3.4A);5OP A 600 ( 4.6A);5OP A 600 ( 2.7A);NAP A 500 (-4.7A);5OP A 600 (-3.7A)","0.45A","2zb7A-2zb4A:60.2","2w98B-2zb4A:97.49"],["2ZB8_A_IMNA800_1","PROSTAGLANDIN REDUCTASE 2","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",8,"TYR A  51;CYH A  54;PHE A  99;TYR A 100;TYR A 259;LEU A 288;VAL A 289;LEU A 290","5OP A 600 (-3.4A);None;5OP A 600 (-4.5A);5OP A 600 (-4.9A);NAP A 500 (-4.4A);NAP A 500 (-4.7A);NAP A 500 ( 3.6A);5OP A 600 (-3.7A)","0.59A","2zb8A-2zb4A:56.8","2zb7A-2zb4A:100.00"],["2ZB8_A_IMNA800_1","PROSTAGLANDIN REDUCTASE 2","2zb4","PROSTAGLANDIN REDUCTASE 2","Homo sapiens",6,"TYR A  51;CYH A  54;THR A  60;TYR A 259;LEU A 288;VAL A 289","5OP A 600 (-3.4A);None;None;NAP A 500 (-4.4A);NAP A 500 (-4.7A);NAP A 500 ( 3.6A)","1.01A","2zb8A-2zb4A:56.8","2zb8A-2zb4A:100.00"]]