SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5NI'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1M8D_A_CLWA906_1 (INDUCIBLE NITRIC OXIDE SYNTHASE)	1m9q	ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens)	5 / 5	PRO A 334 VAL A 336 TYR A 357 MET A 358 GLU A 361	5NI A 907 ( 4.8A) 5NI A 907 (-4.4A) 5NI A 907 (-4.6A) HEM A 901 ( 4.4A) HEM A 901 ( 3.1A)	0.40A	1m8dA-1m9qA: 55.6	1m8dA-1m9qA: 61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1M8D_B_CLWB907_1 (INDUCIBLE NITRIC OXIDE SYNTHASE)	1m9q	ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens)	5 / 5	PRO A 334 VAL A 336 TYR A 357 MET A 358 GLU A 361	5NI A 907 ( 4.8A) 5NI A 907 (-4.4A) 5NI A 907 (-4.6A) HEM A 901 ( 4.4A) HEM A 901 ( 3.1A)	0.39A	1m8dB-1m9qA: 56.0	1m8dB-1m9qA: 61.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1M9J_A_CLWA906_1 (ENDOTHELIAL NITRIC-OXIDE SYNTHASE)	1m9q	ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens)	5 / 5	PRO A 334 VAL A 336 TYR A 357 MET A 358 GLU A 361	5NI A 907 ( 4.8A) 5NI A 907 (-4.4A) 5NI A 907 (-4.6A) HEM A 901 ( 4.4A) HEM A 901 ( 3.1A)	0.48A	1m9jA-1m9qA: 63.3	1m9jA-1m9qA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1M9J_B_CLWB907_1 (ENDOTHELIAL NITRIC-OXIDE SYNTHASE)	1m9q	ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens)	5 / 5	PRO A 334 VAL A 336 TYR A 357 MET A 358 GLU A 361	5NI A 907 ( 4.8A) 5NI A 907 (-4.4A) 5NI A 907 (-4.6A) HEM A 901 ( 4.4A) HEM A 901 ( 3.1A)	0.25A	1m9jB-1m9qA: 63.9	1m9jB-1m9qA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1m9q	ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens)	4 / 7	TYR A 251 TYR A 357 TYR A 373 ILE A 375	None 5NI A 907 (-4.6A) None None	1.34A	2ph9A-1m9qA: 0.0 2ph9B-1m9qA: 0.0	2ph9A-1m9qA: 21.82 2ph9B-1m9qA: 21.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1M8D_A_CLWA906_1","INDUCIBLE NITRIC OXIDE SYNTHASE","1m9q","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","Homo sapiens",5,"PRO A 334;VAL A 336;TYR A 357;MET A 358;GLU A 361","5NI A 907 ( 4.8A);5NI A 907 (-4.4A);5NI A 907 (-4.6A);HEM A 901 ( 4.4A);HEM A 901 ( 3.1A)","0.40A","1m8dA-1m9qA:55.6",null],["1M8D_B_CLWB907_1","INDUCIBLE NITRIC OXIDE SYNTHASE","1m9q","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","Homo sapiens",5,"PRO A 334;VAL A 336;TYR A 357;MET A 358;GLU A 361","5NI A 907 ( 4.8A);5NI A 907 (-4.4A);5NI A 907 (-4.6A);HEM A 901 ( 4.4A);HEM A 901 ( 3.1A)","0.39A","1m8dB-1m9qA:56.0","1m8dA-1m9qA:61.32"],["1M9J_A_CLWA906_1","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","1m9q","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","Homo sapiens",5,"PRO A 334;VAL A 336;TYR A 357;MET A 358;GLU A 361","5NI A 907 ( 4.8A);5NI A 907 (-4.4A);5NI A 907 (-4.6A);HEM A 901 ( 4.4A);HEM A 901 ( 3.1A)","0.48A","1m9jA-1m9qA:63.3","1m8dB-1m9qA:61.32"],["1M9J_B_CLWB907_1","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","1m9q","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","Homo sapiens",5,"PRO A 334;VAL A 336;TYR A 357;MET A 358;GLU A 361","5NI A 907 ( 4.8A);5NI A 907 (-4.4A);5NI A 907 (-4.6A);HEM A 901 ( 4.4A);HEM A 901 ( 3.1A)","0.25A","1m9jB-1m9qA:63.9","1m9jA-1m9qA:100.00"],["2PH9_A_GNTA301_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","1m9q","ENDOTHELIAL NITRIC-OXIDE SYNTHASE","Homo sapiens",4,"TYR A 251;TYR A 357;TYR A 373;ILE A 375","None;5NI A 907 (-4.6A);None;None","1.34A","2ph9A-1m9qA:0.0;2ph9B-1m9qA:0.0","1m9jB-1m9qA:100.00"]]