SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5N1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.87A 1cd2A-5ecxA:
19.5		 1cd2A-5ecxA:
27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
GLN A  28
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-3.4A)
None
None
 0.91A 1df7A-5ecxA:
21.8		 1df7A-5ecxA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
GLN A  28
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-3.4A)
5N1  A 202 ( 4.7A)
None
 0.99A 1df7A-5ecxA:
21.8		 1df7A-5ecxA:
33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 11 ALA A   7
ILE A  20
PHE A  31
SER A  49
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-4.1A)
5N1  A 202 (-3.6A)
None
 0.70A 1dg5A-5ecxA:
21.7		 1dg5A-5ecxA:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.88A 1dhfA-5ecxA:
20.2		 1dhfA-5ecxA:
27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
SER A  49
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
 1.08A 1dreA-5ecxA:
24.2		 1dreA-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.90A 1ra8A-5ecxA:
23.2		 1ra8A-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.86A 1rd7A-5ecxA:
22.5		 1rd7A-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
THR A  46
SER A  49
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
 1.04A 1rg7A-5ecxA:
21.9		 1rg7A-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
SER A  49
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
 1.08A 1rx3A-5ecxA:
24.3		 1rx3A-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.87A 1rx7A-5ecxA:
22.2		 1rx7A-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
LEU A  53
PRO A  54
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
5N1  A 202 ( 4.7A)
None
None
 1.03A 1rx8A-5ecxA:
24.0		 1rx8A-5ecxA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
PRO A  54
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
None
None
None
 0.95A 2d0kA-5ecxA:
22.4		 2d0kA-5ecxA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		4 / 6 ALA A   7
TYR A 102
ILE A  20
ILE A  14
 5N1  A 202 ( 3.5A)
None
NAP  A 201 (-4.1A)
NAP  A 201 (-3.9A)
 1.16A 2dcfA-5ecxA:
undetectable		 2dcfA-5ecxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.82A 2oipA-5ecxA:
22.1		 2oipA-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.65A 2oipA-5ecxA:
22.1		 2oipA-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.83A 2oipB-5ecxA:
20.2		 2oipB-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.64A 2oipB-5ecxA:
20.2		 2oipB-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.79A 2oipC-5ecxA:
21.7		 2oipC-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.64A 2oipC-5ecxA:
21.7		 2oipC-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.85A 2oipD-5ecxA:
22.5		 2oipD-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.62A 2oipD-5ecxA:
22.5		 2oipD-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.82A 2oipE-5ecxA:
21.2		 2oipE-5ecxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.57A 2oipE-5ecxA:
21.2		 2oipE-5ecxA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
LEU A  53
PRO A  54
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
None
 0.67A 2qk8A-5ecxA:
22.9		 2qk8A-5ecxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PRO A  54
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
None
None
None
 0.82A 2qk8A-5ecxA:
22.9		 2qk8A-5ecxA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 11 ALA A   7
GLU A  27
PHE A  31
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
 0.24A 2w3aA-5ecxA:
20.2		 2w3aA-5ecxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 10 ALA A   7
GLU A  27
PHE A  31
THR A  46
LEU A  53
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
 0.78A 2w3aB-5ecxA:
20.2		 2w3aB-5ecxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 10 ALA A   7
GLU A  27
PHE A  31
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
 0.23A 2w3aB-5ecxA:
20.2		 2w3aB-5ecxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.89A 2w3bA-5ecxA:
20.1		 2w3bA-5ecxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
None
None
 0.84A 2w3mB-5ecxA:
20.1		 2w3mB-5ecxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
5N1  A 202 ( 4.7A)
None
 0.75A 2w3mB-5ecxA:
20.1		 2w3mB-5ecxA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
PHE A  31
SER A  49
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-4.1A)
5N1  A 202 (-3.6A)
None
 0.74A 2w3vA-5ecxA:
22.4		 2w3vA-5ecxA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		4 / 7 ALA A   7
TYR A 102
ILE A  20
ILE A  14
 5N1  A 202 ( 3.5A)
None
NAP  A 201 (-4.1A)
NAP  A 201 (-3.9A)
 1.14A 2zm7A-5ecxA:
undetectable		 2zm7A-5ecxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		6 / 12 ALA A   7
ILE A  20
THR A  46
LEU A  53
PRO A  54
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
None
 1.08A 3cl9A-5ecxA:
19.5		 3cl9A-5ecxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
SER A  49
PRO A  54
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-3.6A)
None
None
None
 0.96A 3cl9A-5ecxA:
19.5		 3cl9A-5ecxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		6 / 12 ALA A   7
THR A  46
SER A  49
LEU A  53
PRO A  54
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
None
 1.12A 3cl9A-5ecxA:
19.5		 3cl9A-5ecxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.91A 3clbC-5ecxA:
19.7		 3clbC-5ecxA:
13.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
LEU A  53
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
None
 0.81A 3datA-5ecxA:
23.6		 3datA-5ecxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 MET A   5
ALA A   7
GLU A  27
LEU A  53
TYR A 102
 5N1  A 202 (-4.8A)
5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
 0.91A 3fl9B-5ecxA:
22.7		 3fl9B-5ecxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 9 MET A   5
ALA A   7
GLU A  27
LEU A  53
TYR A 102
 5N1  A 202 (-4.8A)
5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
 0.78A 3fl9D-5ecxA:
22.9		 3fl9D-5ecxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 MET A   5
ALA A   7
GLU A  27
LEU A  53
TYR A 102
 5N1  A 202 (-4.8A)
5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
 0.90A 3fl9G-5ecxA:
22.6		 3fl9G-5ecxA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.83A 3hj3A-5ecxA:
22.8		 3hj3A-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.68A 3hj3A-5ecxA:
22.8		 3hj3A-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.80A 3hj3B-5ecxA:
22.7		 3hj3B-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.67A 3hj3B-5ecxA:
22.7		 3hj3B-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.75A 3hj3C-5ecxA:
21.3		 3hj3C-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.62A 3hj3C-5ecxA:
21.3		 3hj3C-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.48A 3hj3D-5ecxA:
18.3		 3hj3D-5ecxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
None
None
 0.77A 3ia4C-5ecxA:
24.5		 3ia4C-5ecxA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
5N1  A 202 ( 4.7A)
None
 0.54A 3ia4C-5ecxA:
24.5		 3ia4C-5ecxA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
SER A  49
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
 0.90A 3ia4C-5ecxA:
24.5		 3ia4C-5ecxA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
None
None
 0.78A 3ia4D-5ecxA:
24.5		 3ia4D-5ecxA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
5N1  A 202 ( 4.7A)
None
 0.55A 3ia4D-5ecxA:
24.5		 3ia4D-5ecxA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
SER A  49
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
5N1  A 202 (-3.6A)
5N1  A 202 ( 4.7A)
None
 0.89A 3ia4D-5ecxA:
24.5		 3ia4D-5ecxA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 10 MET A   5
ALA A   7
GLU A  27
LEU A  53
TYR A 102
 5N1  A 202 (-4.8A)
5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
 0.50A 3jw3A-5ecxA:
23.7		 3jw3A-5ecxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 9 MET A   5
ALA A   7
GLU A  27
LEU A  53
TYR A 102
 5N1  A 202 (-4.8A)
5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 ( 4.7A)
None
 0.41A 3jw3B-5ecxA:
23.7		 3jw3B-5ecxA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 11 ALA A   7
GLU A  27
PHE A  31
THR A  46
LEU A  53
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
 0.86A 3n0hA-5ecxA:
20.4		 3n0hA-5ecxA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 11 ALA A   7
GLU A  27
PHE A  31
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
 0.30A 3n0hA-5ecxA:
20.4		 3n0hA-5ecxA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
PHE A  31
THR A  46
SER A  49
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.6A)
 0.89A 3qfxA-5ecxA:
19.5		 3qfxA-5ecxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
PHE A  31
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
 0.26A 3qfxA-5ecxA:
19.5		 3qfxA-5ecxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
PHE A  31
THR A  46
SER A  49
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.6A)
 0.90A 3qfxB-5ecxA:
19.5		 3qfxB-5ecxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
ILE A  20
PHE A  31
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
NAP  A 201 (-4.1A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
 0.28A 3qfxB-5ecxA:
19.5		 3qfxB-5ecxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		6 / 12 ALA A   7
GLU A  27
PHE A  31
LYS A  32
THR A  46
LEU A  53
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
5N1  A 202 (-2.9A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
 0.92A 3s3vA-5ecxA:
20.3		 3s3vA-5ecxA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		6 / 12 ALA A   7
GLU A  27
PHE A  31
LYS A  32
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
5N1  A 202 (-2.9A)
NAP  A 201 (-3.2A)
None
 0.47A 3s3vA-5ecxA:
20.3		 3s3vA-5ecxA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
ARG A  56
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
None
None
 0.86A 4cd2A-5ecxA:
18.4		 4cd2A-5ecxA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
5N1  A 202 ( 4.7A)
None
 0.85A 4cd2A-5ecxA:
18.4		 4cd2A-5ecxA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
GLU A  27
PHE A  31
THR A  46
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-2.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
 0.39A 4cd2A-5ecxA:
18.4		 4cd2A-5ecxA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		4 / 6 PHE A  31
GLY A  97
LEU A  40
VAL A  42
 5N1  A 202 (-4.1A)
NAP  A 201 ( 3.8A)
None
None
 0.95A 4dubA-5ecxA:
undetectable		 4dubA-5ecxA:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.92A 4ej1B-5ecxA:
22.2		 4ej1B-5ecxA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.88A 4kebB-5ecxA:
20.1		 4kebB-5ecxA:
27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.78A 4kjlA-5ecxA:
24.0		 4kjlA-5ecxA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.85A 4m6kA-5ecxA:
20.5		 4m6kA-5ecxA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.83A 4nx6A-5ecxA:
24.5		 4nx6A-5ecxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
PRO A  54
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 1.02A 4p3qA-5ecxA:
24.3		 4p3qA-5ecxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
PRO A  54
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
None
None
 0.62A 4p3qA-5ecxA:
24.3		 4p3qA-5ecxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.80A 4pstA-5ecxA:
undetectable		 4pstA-5ecxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.87A 4qlgB-5ecxA:
23.2		 4qlgB-5ecxA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.86A 4x5fA-5ecxA:
23.1		 4x5fA-5ecxA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.85A 4x5fB-5ecxA:
23.5		 4x5fB-5ecxA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 10 ALA A   7
PHE A  31
THR A  46
MET A  50
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.2A)
None
 0.79A 6aogA-5ecxA:
20.5		 6aogA-5ecxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 10 ALA A   7
PHE A  31
THR A  46
MET A  50
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 (-3.2A)
None
 0.79A 6aogB-5ecxA:
20.3		 6aogB-5ecxA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ecx DEHYDROFOLATE
REDUCTASE TYPE I
(Klebsiella
pneumoniae) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  53
TYR A 102
 5N1  A 202 ( 3.5A)
5N1  A 202 (-4.1A)
NAP  A 201 (-3.2A)
5N1  A 202 ( 4.7A)
None
 0.84A 7dfrA-5ecxA:
24.3		 7dfrA-5ecxA:
30.06