SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5IP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		5 / 11 SER A 106
ASN A  69
ARG A  68
GLY A 288
THR A 260
 GOL  A1007 ( 3.9A)
None
5IP  A 401 (-3.9A)
None
None
 1.19A 1jr1A-3mozA:
undetectable		 1jr1A-3mozA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		3 / 3 THR A 259
GLU A 136
HIS A 224
 PO4  A 400 (-3.8A)
None
5IP  A 401 (-3.8A)
 0.73A 1xwfA-3mozA:
undetectable		 1xwfA-3mozA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		3 / 3 THR A 259
GLU A 136
HIS A 224
 PO4  A 400 (-3.8A)
None
5IP  A 401 (-3.8A)
 0.77A 1xwfB-3mozA:
undetectable		 1xwfB-3mozA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		3 / 3 THR A 259
GLU A 136
HIS A 224
 PO4  A 400 (-3.8A)
None
5IP  A 401 (-3.8A)
 0.79A 1xwfC-3mozA:
undetectable		 1xwfC-3mozA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		3 / 3 THR A 259
GLU A 136
HIS A 224
 PO4  A 400 (-3.8A)
None
5IP  A 401 (-3.8A)
 0.76A 1xwfD-3mozA:
undetectable		 1xwfD-3mozA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		3 / 3 LYS A 312
ASP A 153
ASP A  59
 5IP  A 401 (-3.0A)
5IP  A 401 ( 4.9A)
None
 1.13A 2br4A-3mozA:
undetectable		 2br4A-3mozA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		4 / 8 ASP A 153
ASP A 132
GLU A 253
GLU A 168
 5IP  A 401 ( 4.9A)
None
None
None
 1.02A 4gkhC-3mozA:
undetectable
4gkhK-3mozA:
undetectable		 4gkhC-3mozA:
20.85
4gkhK-3mozA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE
(Selenomonas
ruminantium) 		4 / 8 ASP A 153
ASP A 132
GLU A 253
GLU A 168
 5IP  A 401 ( 4.9A)
None
None
None
 1.03A 4gkiE-3mozA:
undetectable
4gkiG-3mozA:
undetectable		 4gkiE-3mozA:
20.85
4gkiG-3mozA:
20.85