SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ID'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 12 TRP A 652
GLY A 653
LEU A 748
ILE A 610
LEU A 657
 None
5ID  A1800 (-3.9A)
None
None
None
 1.02A 1kyvA-2vuwA:
undetectable
1kyvE-2vuwA:
undetectable		 1kyvA-2vuwA:
18.08
1kyvE-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 11 ILE A 610
LEU A 657
TRP A 652
GLY A 653
LEU A 748
 None
None
None
5ID  A1800 (-3.9A)
None
 1.01A 1kyvA-2vuwA:
undetectable
1kyvB-2vuwA:
undetectable		 1kyvA-2vuwA:
18.08
1kyvB-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 12 ILE A 610
LEU A 657
TRP A 652
GLY A 653
LEU A 748
 None
None
None
5ID  A1800 (-3.9A)
None
 1.03A 1kyvB-2vuwA:
undetectable
1kyvC-2vuwA:
undetectable		 1kyvB-2vuwA:
18.08
1kyvC-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 12 ILE A 610
LEU A 657
TRP A 652
GLY A 653
LEU A 748
 None
None
None
5ID  A1800 (-3.9A)
None
 1.01A 1kyvC-2vuwA:
undetectable
1kyvD-2vuwA:
undetectable		 1kyvC-2vuwA:
18.08
1kyvD-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 12 ILE A 610
LEU A 657
TRP A 652
GLY A 653
LEU A 748
 None
None
None
5ID  A1800 (-3.9A)
None
 1.03A 1kyvD-2vuwA:
undetectable
1kyvE-2vuwA:
undetectable		 1kyvD-2vuwA:
18.08
1kyvE-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		3 / 3 ASP A 611
HIS A 651
ASP A 687
 5ID  A1800 (-3.6A)
None
IOD  A1799 (-4.0A)
 0.78A 1nw5A-2vuwA:
undetectable		 1nw5A-2vuwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 10 GLU A 120
GLY A 123
GLY A 174
LEU A 119
ALA A  73
 None
None
None
5ID  A1300 ( 4.7A)
5ID  A1300 ( 3.8A)
 1.16A 1x7pA-2c47A:
undetectable
1x7pB-2c47A:
undetectable		 1x7pA-2c47A:
21.96
1x7pB-2c47A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 10 ALA A 509
ILE A 557
ASP A 611
LEU A 656
ILE A 686
 5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
IOD  A1799 (-4.2A)
 0.72A 1yi4A-2vuwA:
17.2		 1yi4A-2vuwA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		8 / 12 ILE A 490
VAL A 498
LYS A 511
PHE A 605
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 None
5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.72A 2eufB-2vuwA:
13.1		 2eufB-2vuwA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		3 / 3 HIS A 182
ILE A 184
LEU A 122
 None
None
5ID  A1300 (-4.2A)
 0.55A 2kceA-2c47A:
undetectable		 2kceA-2c47A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 12 ILE A 490
VAL A 498
ALA A 509
ILE A 557
PHE A 605
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.5A)
 0.50A 2y7jA-2vuwA:
18.9		 2y7jA-2vuwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 10 ILE A 490
VAL A 498
ALA A 509
ILE A 557
PHE A 605
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.5A)
 0.49A 2y7jB-2vuwA:
18.9		 2y7jB-2vuwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 10 ILE A 490
VAL A 498
ALA A 509
ILE A 557
PHE A 605
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.5A)
 0.51A 2y7jC-2vuwA:
18.9		 2y7jC-2vuwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 10 ILE A 490
VAL A 498
ALA A 509
ILE A 557
PHE A 605
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.5A)
 0.53A 2y7jD-2vuwA:
18.9		 2y7jD-2vuwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		4 / 8 ALA A 509
LYS A 511
GLU A 535
LEU A 603
 5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
 0.40A 3lfaA-2vuwA:
14.6		 3lfaA-2vuwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 9 ILE A 490
ALA A 509
LYS A 511
PHE A 605
PHE A 607
 None
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.3A)
 0.58A 3miyB-2vuwA:
12.4		 3miyB-2vuwA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 4 LEU A 122
GLY A 123
GLY A 174
THR A 178
 5ID  A1300 (-4.2A)
None
None
None
 0.81A 3si7A-2c47A:
undetectable		 3si7A-2c47A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 122
GLY A 123
GLY A 174
THR A 178
 5ID  A1300 (-4.2A)
None
None
None
 0.80A 3si7C-2c47A:
undetectable
3si7D-2c47A:
undetectable		 3si7C-2c47A:
21.08
3si7D-2c47A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 9 ILE A 490
ALA A 509
PHE A 605
PHE A 607
ASP A 611
LEU A 656
 None
5ID  A1800 (-3.4A)
5ID  A1800 (-4.1A)
5ID  A1800 (-4.3A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
 0.52A 3ti1A-2vuwA:
16.0		 3ti1A-2vuwA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 9 PHE A 605
PHE A 607
ASP A 611
LEU A 656
ASP A 687
 5ID  A1800 (-4.1A)
5ID  A1800 (-4.3A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.94A 3ti1A-2vuwA:
16.0		 3ti1A-2vuwA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 12 ILE A 490
GLY A 493
GLY A 496
VAL A 498
ALA A 509
LYS A 511
ASP A 687
 None
None
None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
IOD  A1799 (-4.0A)
 0.60A 3v5wA-2vuwA:
17.1		 3v5wA-2vuwA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 8 VAL A 498
LYS A 511
ILE A 557
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.60A 3warA-2vuwA:
16.5		 3warA-2vuwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		10 / 12 PHE A 495
VAL A 498
ALA A 509
ILE A 557
ASP A 611
ASP A 649
ASN A 654
LEU A 656
ILE A 686
ASP A 687
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.6A)
None
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.84A 4i41A-2vuwA:
17.2		 4i41A-2vuwA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		7 / 11 ALA A  73
LYS A  75
LEU A 119
GLU A 169
LEU A 172
ILE A 187
ASP A 188
 5ID  A1300 ( 3.8A)
None
5ID  A1300 ( 4.7A)
None
5ID  A1300 (-4.6A)
5ID  A1300 (-3.9A)
None
 0.96A 4iaaA-2c47A:
21.6		 4iaaA-2c47A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 11 VAL A 498
ALA A 509
LYS A 511
ASP A 611
LEU A 656
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.79A 4iaaA-2vuwA:
16.8		 4iaaA-2vuwA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 12 GLY A 491
VAL A 498
ALA A 509
LEU A 559
LEU A 603
LEU A 656
ILE A 686
 5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
None
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.2A)
 0.54A 4ifgA-2vuwA:
14.4		 4ifgA-2vuwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 8 GLY A 493
VAL A 498
ALA A 509
LYS A 511
ASP A 611
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
 0.92A 4l9iB-2vuwA:
15.6		 4l9iB-2vuwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 8 ILE A 490
VAL A 498
ALA A 509
ASP A 611
ASN A 654
LEU A 656
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
 0.58A 4ogrA-2vuwA:
16.9		 4ogrA-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 8 VAL A 498
ALA A 509
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.56A 4ogrA-2vuwA:
16.9		 4ogrA-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 7 ALA A 509
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.46A 4ogrE-2vuwA:
16.5		 4ogrE-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 7 GLY A 491
ALA A 509
ASP A 611
ASN A 654
LEU A 656
 5ID  A1800 (-3.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
 0.85A 4ogrE-2vuwA:
16.5		 4ogrE-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 9 ILE A 490
VAL A 498
ALA A 509
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.71A 4ogrI-2vuwA:
12.2		 4ogrI-2vuwA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 12 GLY A 491
GLY A 493
GLY A 496
VAL A 498
ALA A 509
LYS A 511
LEU A 656
 5ID  A1800 (-3.5A)
None
None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.5A)
 0.53A 4otiA-2vuwA:
14.6		 4otiA-2vuwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		6 / 11 ILE A  52
ALA A  73
LYS A  75
GLU A  89
LEU A 172
ASP A 188
 None
5ID  A1300 ( 3.8A)
None
None
5ID  A1300 (-4.6A)
None
 0.70A 4qmsA-2c47A:
23.8		 4qmsA-2c47A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		6 / 11 ILE A  52
ALA A  73
LYS A  75
LEU A 122
LEU A 172
ASP A 188
 None
5ID  A1300 ( 3.8A)
None
5ID  A1300 (-4.2A)
5ID  A1300 (-4.6A)
None
 0.75A 4qmsA-2c47A:
23.8		 4qmsA-2c47A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 11 ILE A 490
ALA A 509
LYS A 511
GLU A 535
LEU A 656
ASP A 687
 None
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.81A 4qmsA-2vuwA:
17.9		 4qmsA-2vuwA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		4 / 8 VAL A 498
ILE A 557
HIS A 647
LEU A 656
 5ID  A1800 ( 4.5A)
5ID  A1800 ( 4.5A)
None
5ID  A1800 (-4.5A)
 0.58A 4qrcA-2vuwA:
undetectable		 4qrcA-2vuwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		4 / 8 VAL A 498
LYS A 511
ILE A 557
LEU A 656
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.5A)
 0.80A 4qrcA-2vuwA:
undetectable		 4qrcA-2vuwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 10 ILE A  52
ALA A  73
LYS A  75
LEU A 121
LEU A 172
 None
5ID  A1300 ( 3.8A)
None
5ID  A1300 (-4.5A)
5ID  A1300 (-4.6A)
 0.58A 4rz7A-2c47A:
22.6		 4rz7A-2c47A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 10 ILE A 490
ALA A 509
LYS A 511
ILE A 557
LEU A 656
 None
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.5A)
 0.55A 4rz7A-2vuwA:
15.3		 4rz7A-2vuwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 12 GLU A  77
ILE A  74
ALA A  73
VAL A  72
PHE A  46
 None
None
5ID  A1300 ( 3.8A)
None
None
 0.96A 4u8yB-2c47A:
3.1		 4u8yB-2c47A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 12 GLU A  77
ILE A  74
ALA A  73
VAL A  72
PHE A  46
 None
None
5ID  A1300 ( 3.8A)
None
None
 0.97A 4u95B-2c47A:
2.6		 4u95B-2c47A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 9 VAL A 498
LYS A 511
ILE A 557
ARG A 648
LEU A 656
ILE A 685
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
None
5ID  A1800 (-4.5A)
None
 0.80A 4v01B-2vuwA:
15.0		 4v01B-2vuwA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		4 / 7 GLY A 491
GLY A 493
VAL A 498
LYS A 511
 5ID  A1800 (-3.5A)
None
5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
 0.45A 5izjA-2vuwA:
15.7		 5izjA-2vuwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 12 ILE A 490
GLY A 491
VAL A 498
ALA A 509
PHE A 605
ASP A 611
LEU A 656
 None
5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 (-4.1A)
5ID  A1800 (-3.6A)
5ID  A1800 (-4.5A)
 0.85A 5l2iA-2vuwA:
15.5		 5l2iA-2vuwA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 9 ILE A 490
GLY A 491
VAL A 498
ALA A 509
ILE A 557
 None
5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
 0.41A 5lw1B-2vuwA:
9.5		 5lw1B-2vuwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		7 / 12 ILE A 490
GLY A 491
VAL A 498
ALA A 509
LYS A 511
GLU A 535
ILE A 686
 None
5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
IOD  A1799 (-4.2A)
 0.67A 5mafA-2vuwA:
17.8		 5mafA-2vuwA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		4 / 8 ALA A 509
GLU A 535
LEU A 656
ASP A 687
 5ID  A1800 (-3.4A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.55A 5owrA-2vuwA:
15.8		 5owrA-2vuwA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 12 ALA A 509
LYS A 511
GLU A 535
LEU A 603
GLY A 609
GLN A 614
 5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
5ID  A1800 (-4.7A)
5ID  A1800 ( 4.9A)
 0.83A 5vcvA-2vuwA:
18.9		 5vcvA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 12 VAL A 498
ALA A 509
GLU A 535
LEU A 603
GLY A 609
GLN A 614
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
None
None
5ID  A1800 (-4.7A)
5ID  A1800 ( 4.9A)
 0.84A 5vcyA-2vuwA:
18.6		 5vcyA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 12 VAL A 498
ALA A 509
LYS A 511
GLU A 535
LEU A 603
GLN A 614
 5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
None
5ID  A1800 ( 4.9A)
 0.81A 5vcyA-2vuwA:
18.6		 5vcyA-2vuwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		7 / 12 ALA A  73
LYS A  75
GLU A  89
LEU A 121
GLY A 123
LEU A 172
ASP A 188
 5ID  A1300 ( 3.8A)
None
None
5ID  A1300 (-4.5A)
None
5ID  A1300 (-4.6A)
None
 0.99A 5y7zB-2c47A:
21.9		 5y7zB-2c47A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 8 VAL A 498
LYS A 511
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.37A 5y9mA-2vuwA:
15.4		 5y9mA-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 8 VAL A 498
LYS A 511
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.33A 5y9mX-2vuwA:
10.9		 5y9mX-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		5 / 7 VAL A 498
LYS A 511
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.46A 5yf9B-2vuwA:
15.3		 5yf9B-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 9 VAL A 498
LYS A 511
ILE A 557
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.58A 5yf9X-2vuwA:
15.7		 5yf9X-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens) 		6 / 7 VAL A 498
LYS A 511
ILE A 557
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.53A 5ywmX-2vuwA:
16.0		 5ywmX-2vuwA:
12.80