SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5GP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 ARG A  44
ASP A 103
TYR A  53
ARG A  41
 5GP  A1202 (-3.1A)
5GP  A1202 (-3.8A)
5GP  A1202 (-4.5A)
5GP  A1202 (-3.8A)
 1.37A 1cebA-1lvgA:
undetectable		 1cebA-1lvgA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 4 VAL A   8
PHE A 165
SER A  10
VAL A 102
 None
None
None
5GP  A1202 (-3.7A)
 1.46A 1e7cA-1lvgA:
undetectable		 1e7cA-1lvgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 5 HIS A  86
HIS A 219
HIS A 241
HIS A  91
 MN  A 301 (-3.4A)
5GP  A 303 (-4.1A)
MN  A 300 ( 3.4A)
MN  A 300 (-3.4A)
 0.92A 1e9yB-3py6A:
undetectable		 1e9yB-3py6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 5 ASP A 188
HIS A 170
HIS A 241
HIS A 219
 MN  A 300 (-2.5A)
MN  A 301 ( 3.4A)
MN  A 300 ( 3.4A)
5GP  A 303 (-4.1A)
 1.21A 1ei6A-3py6A:
undetectable		 1ei6A-3py6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 8 ASP A  90
HIS A 170
HIS A 241
HIS A 219
 MN  A 300 ( 2.6A)
MN  A 301 ( 3.4A)
MN  A 300 ( 3.4A)
5GP  A 303 (-4.1A)
 1.00A 1ei6C-3py6A:
undetectable		 1ei6C-3py6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 11 ASP A 129
ASN A 158
GLY A 181
CYH A 186
THR A 188
 None
5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
 1.11A 1jr1A-2bwgA:
39.2		 1jr1A-2bwgA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 11 ASP A 277
ASN A 306
ARG A 325
GLY A 331
GLY A 418
 None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
5GP  A 600 (-3.3A)
5GP  A 600 (-3.1A)
 1.08A 1jr1A-5tc3A:
59.0		 1jr1A-5tc3A:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		9 / 11 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLY A 329
THR A 336
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-3.1A)
 0.70A 1jr1A-5tc3A:
59.0		 1jr1A-5tc3A:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		8 / 11 ASP A 277
SER A 279
ASN A 306
ARG A 325
MET A 328
GLY A 329
THR A 336
GLN A 448
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
None
 0.34A 1jr1A-5tc3A:
59.0		 1jr1A-5tc3A:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 11 SER A 279
ASN A 306
MET A 328
GLY A 329
THR A 336
GLY A 449
GLN A 448
 None
5GP  A 600 (-3.2A)
None
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 ( 3.8A)
None
 1.21A 1jr1A-5tc3A:
59.0		 1jr1A-5tc3A:
62.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ASN A 158
GLY A 181
THR A 188
GLY A 290
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.1A)
 0.84A 1jr1B-2bwgA:
39.0		 1jr1B-2bwgA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 8 ASP A 277
ASN A 306
ARG A 325
GLY A 331
GLY A 418
 None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
5GP  A 600 (-3.3A)
5GP  A 600 (-3.1A)
 0.95A 1jr1B-5tc3A:
58.1		 1jr1B-5tc3A:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 8 ASP A 277
SER A 279
ASN A 306
ARG A 325
GLY A 329
THR A 336
GLN A 448
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
None
 0.35A 1jr1B-5tc3A:
58.1		 1jr1B-5tc3A:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 8 ASP A 277
SER A 279
ASN A 306
ARG A 325
GLY A 329
THR A 336
GLY A 418
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-3.1A)
 0.57A 1jr1B-5tc3A:
58.1		 1jr1B-5tc3A:
62.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		6 / 8 ASP A 277
SER A 278
SER A 279
ASN A 306
GLY A 329
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-3.1A)
 0.59A 1me7A-5tc3A:
46.8		 1me7A-5tc3A:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		6 / 10 ASP A 277
SER A 278
SER A 279
ASN A 306
GLY A 329
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-3.1A)
 0.56A 1mehA-5tc3A:
45.0		 1mehA-5tc3A:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 8 ASP A 277
SER A 278
SER A 279
ASN A 306
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
 0.58A 1meiA-5tc3A:
46.0		 1meiA-5tc3A:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3lnc GUANYLATE KINASE
(Anaplasma
phagocytophilum) 		5 / 12 THR A  41
GLY A  84
GLU A  74
VAL A  38
VAL A  85
 None
5GP  A 300 (-3.3A)
5GP  A 300 (-2.9A)
None
5GP  A 300 (-4.1A)
 1.29A 1n2xA-3lncA:
undetectable		 1n2xA-3lncA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.60A 1oe1A-3rl3A:
undetectable		 1oe1A-3rl3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.59A 1oe3A-3rl3A:
undetectable		 1oe3A-3rl3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 TRP A 222
VAL A 223
PRO A 224
 None
5GP  A 951 ( 4.9A)
None
 0.77A 1rg1A-3rl3A:
undetectable		 1rg1A-3rl3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 TRP A 222
VAL A 223
PRO A 224
 None
5GP  A 951 ( 4.9A)
None
 0.78A 1rh0A-3rl3A:
undetectable		 1rh0A-3rl3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.18A 1vidA-2jkyA:
3.5		 1vidA-2jkyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Bacillus
subtilis) 		5 / 10 ILE A 395
GLY A 351
ILE A 373
LEU A 413
PHE A 415
 None
5GP  A 467 (-3.2A)
None
None
None
 0.97A 1z11C-1ao0A:
0.0		 1z11C-1ao0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE
(Bacillus
subtilis) 		5 / 10 ILE A 395
GLY A 351
ILE A 373
LEU A 413
PHE A 415
 None
5GP  A 467 (-3.2A)
None
None
None
 0.96A 1z11D-1ao0A:
0.0		 1z11D-1ao0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 GLY A 113
LEU A 136
ASP A 157
VAL A 158
LEU A 175
 5GP  A 500 ( 4.5A)
None
5GP  A 500 (-2.7A)
5GP  A 500 (-3.6A)
5GP  A 500 ( 4.7A)
 0.86A 1zq9B-3b89A:
11.5		 1zq9B-3b89A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		4 / 8 LEU A  41
GLU A  76
LEU A 104
HIS A 103
 5GP  A 200 (-4.2A)
None
None
5GP  A 200 (-4.1A)
 0.89A 2azxA-3n1tA:
undetectable		 2azxA-3n1tA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.19A 2cl5B-2jkyA:
4.0		 2cl5B-2jkyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 VAL A 180
GLY A 181
GLY A 183
THR A 188
ALA A 287
 None
K  A1339 (-4.8A)
5GP  A1340 ( 3.2A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.9A)
 1.04A 2egvA-2bwgA:
undetectable		 2egvA-2bwgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 VAL A 180
GLY A 181
GLY A 183
THR A 188
ALA A 287
 None
K  A1339 (-4.8A)
5GP  A1340 ( 3.2A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.9A)
 1.08A 2egvB-2bwgA:
undetectable		 2egvB-2bwgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 ASP A 109
GLY A 113
ILE A 132
LEU A 175
LEU A 179
 None
5GP  A 500 ( 4.5A)
5GP  A 500 (-4.1A)
5GP  A 500 ( 4.7A)
None
 0.79A 2nxeA-3b89A:
12.8		 2nxeA-3b89A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 PRO A  43
TYR A  11
TYR A 191
PRO A 192
 None
None
5GP  A 300 (-4.6A)
None
 1.26A 2ombA-2jkyA:
undetectable
2ombB-2jkyA:
undetectable		 2ombA-2jkyA:
22.45
2ombB-2jkyA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 1c9k ADENOSYLCOBINAMIDE
KINASE
(Salmonella
enterica) 		5 / 12 LEU A  89
ASN A  88
LEU A  90
VAL A 157
THR A  31
 None
None
None
None
5GP  A 604 (-4.6A)
 1.33A 2q7kA-1c9kA:
undetectable		 2q7kA-1c9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1c9k ADENOSYLCOBINAMIDE
KINASE
(Salmonella
enterica) 		5 / 12 LEU A  89
ASN A  88
LEU A  90
VAL A 157
THR A  31
 None
None
None
None
5GP  A 604 (-4.6A)
 1.32A 2q7lA-1c9kA:
undetectable		 2q7lA-1c9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		4 / 6 LEU A  61
ILE A  96
ILE A 365
ARG A 325
 None
None
None
5GP  A 600 (-3.1A)
 0.98A 2q8hA-5tc3A:
undetectable		 2q8hA-5tc3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2fxv XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
subtilis) 		4 / 7 ALA A 133
GLY A 135
VAL A  96
LEU A 127
 None
None
None
5GP  A 200 ( 4.8A)
 0.73A 2uyqA-2fxvA:
3.9		 2uyqA-2fxvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 7 ALA A 111
GLY A 113
ASP A 131
ASP A 157
 5GP  A 500 (-3.1A)
5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-2.7A)
 0.51A 2uyqA-3b89A:
10.3		 2uyqA-3b89A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.62A 2xxgA-3rl3A:
undetectable		 2xxgA-3rl3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.63A 2xxgC-3rl3A:
undetectable		 2xxgC-3rl3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 1c9k ADENOSYLCOBINAMIDE
KINASE
(Salmonella
enterica) 		5 / 12 LEU A  89
ASN A  88
LEU A  90
VAL A 157
THR A  31
 None
None
None
None
5GP  A 604 (-4.6A)
 1.39A 2yloA-1c9kA:
undetectable		 2yloA-1c9kA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 4 GLY A  82
GLU A  72
ASP A 101
TYR A  53
 5GP  A1202 (-3.2A)
5GP  A1202 (-2.9A)
5GP  A1202 ( 3.4A)
5GP  A1202 (-4.5A)
 1.06A 2yvlC-1lvgA:
undetectable		 2yvlC-1lvgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.79A 2zthA-1lvgA:
undetectable		 2zthA-1lvgA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.22A 2zvjA-2jkyA:
4.1		 2zvjA-2jkyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2qor GUANYLATE KINASE
(Plasmodium
vivax) 		4 / 8 SER A  37
GLY A  11
ASN A 103
ALA A 161
 5GP  A 197 (-2.5A)
None
5GP  A 197 (-3.5A)
None
 0.95A 3aodA-2qorA:
undetectable		 3aodA-2qorA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 MET A 381
ALA A 450
THR A 383
PHE A 204
GLY A 407
 5GP  A 501 (-4.4A)
None
None
5GP  A 501 (-3.6A)
5GP  A 501 (-3.3A)
 1.31A 3aodC-4dwqA:
1.6		 3aodC-4dwqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 10 GLY A 113
ASP A 131
ILE A 132
ASP A 157
LEU A 175
 5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-4.1A)
5GP  A 500 (-2.7A)
5GP  A 500 ( 4.7A)
 0.78A 3ay0B-3b89A:
12.7		 3ay0B-3b89A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 10 GLY A 113
ASP A 131
ILE A 132
ASP A 157
VAL A 158
 5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-4.1A)
5GP  A 500 (-2.7A)
5GP  A 500 (-3.6A)
 0.72A 3ay0B-3b89A:
12.7		 3ay0B-3b89A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		4 / 5 ASP A 367
ILE A 376
ILE A 365
GLY A 368
 5GP  A 600 (-2.4A)
None
None
5GP  A 600 ( 3.4A)
 0.95A 3bufA-5tc3A:
undetectable		 3bufA-5tc3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.80A 3bwmA-1lvgA:
undetectable		 3bwmA-1lvgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.81A 3bwyA-1lvgA:
undetectable		 3bwyA-1lvgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 5 HIS A 170
HIS A 219
HIS A 241
ASP A  90
 MN  A 301 ( 3.4A)
5GP  A 303 (-4.1A)
MN  A 300 ( 3.4A)
MN  A 300 ( 2.6A)
 1.15A 3c0zA-3py6A:
undetectable		 3c0zA-3py6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 HIS A  81
SER A  83
GLY A 113
ILE A 132
LYS A 174
 5GP  A 500 (-4.7A)
5GP  A 500 (-2.7A)
5GP  A 500 ( 4.5A)
5GP  A 500 (-4.1A)
5GP  A 500 (-4.9A)
 0.98A 3fzgA-3b89A:
21.6		 3fzgA-3b89A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 SER A  83
THR A  84
GLY A 113
ILE A 132
LYS A 174
 5GP  A 500 (-2.7A)
None
5GP  A 500 ( 4.5A)
5GP  A 500 (-4.1A)
5GP  A 500 (-4.9A)
 0.96A 3fzgA-3b89A:
21.6		 3fzgA-3b89A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 1c9k ADENOSYLCOBINAMIDE
KINASE
(Salmonella
enterica) 		4 / 4 ILE A  29
ARG A 124
ILE A  77
THR A  31
 None
None
None
5GP  A 604 (-4.6A)
 1.30A 3ia4C-1c9kA:
2.3		 3ia4C-1c9kA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 8 GLY A 106
CYH A  98
PHE A  32
PHE A  25
 5GP  A1202 (-3.2A)
None
None
None
 1.05A 3ko0B-1lvgA:
0.0
3ko0J-1lvgA:
0.0		 3ko0B-1lvgA:
20.83
3ko0J-1lvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 GLY A 106
CYH A  98
PHE A  32
PHE A  25
 5GP  A1202 (-3.2A)
None
None
None
 1.08A 3ko0L-1lvgA:
undetectable
3ko0N-1lvgA:
undetectable		 3ko0L-1lvgA:
20.83
3ko0N-1lvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 GLY A 183
CYH A 251
PHE A 266
GLY A 268
 5GP  A1340 ( 3.2A)
None
None
5GP  A1340 (-3.3A)
 0.89A 3ko0M-2bwgA:
undetectable
3ko0P-2bwgA:
undetectable		 3ko0M-2bwgA:
13.22
3ko0P-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 GLY A 183
CYH A 251
PHE A 266
GLY A 268
 5GP  A1340 ( 3.2A)
None
None
5GP  A1340 (-3.3A)
 0.89A 3ko0O-2bwgA:
undetectable
3ko0Q-2bwgA:
undetectable		 3ko0O-2bwgA:
13.22
3ko0Q-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 PHE A 266
GLY A 268
GLY A 183
CYH A 251
 None
5GP  A1340 (-3.3A)
5GP  A1340 ( 3.2A)
None
 0.84A 3ko0M-2bwgA:
undetectable
3ko0P-2bwgA:
undetectable		 3ko0M-2bwgA:
13.22
3ko0P-2bwgA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 GLY A 106
CYH A  98
PHE A  32
PHE A  25
 5GP  A1202 (-3.2A)
None
None
None
 1.12A 3ko0R-1lvgA:
0.0
3ko0T-1lvgA:
undetectable		 3ko0R-1lvgA:
20.83
3ko0T-1lvgA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 ARG A  26
ALA A 111
ILE A 132
ASP A 157
LEU A 171
 None
5GP  A 500 (-3.1A)
5GP  A 500 (-4.1A)
5GP  A 500 (-2.7A)
None
 0.97A 3lcvB-3b89A:
27.3		 3lcvB-3b89A:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		8 / 12 ARG A  26
HIS A  81
SER A  83
THR A  84
ALA A 111
ILE A 132
ASP A 157
LYS A 174
 None
5GP  A 500 (-4.7A)
5GP  A 500 (-2.7A)
None
5GP  A 500 (-3.1A)
5GP  A 500 (-4.1A)
5GP  A 500 (-2.7A)
5GP  A 500 (-4.9A)
 0.86A 3lcvB-3b89A:
27.3		 3lcvB-3b89A:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 8 ARG A 181
LEU A 176
LEU A 159
ILE A 172
 None
None
5GP  A 500 ( 4.3A)
None
 0.88A 3ln1A-3b89A:
undetectable		 3ln1A-3b89A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 7 ARG A 181
LEU A 176
LEU A 159
ILE A 172
 None
None
5GP  A 500 ( 4.3A)
None
 0.87A 3ln1B-3b89A:
undetectable		 3ln1B-3b89A:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		8 / 10 ILE A   6
PHE A   7
ILE A  10
ASP A  31
ILE A  32
SER A  33
LEU A  41
HIS A 103
 5GP  A 200 (-3.6A)
None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.7A)
5GP  A 200 (-4.2A)
5GP  A 200 (-4.1A)
 0.61A 3o1cA-3n1tA:
20.4		 3o1cA-3n1tA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		8 / 10 ILE A   6
PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
HIS A  99
HIS A 101
 None
5GP  A 125 (-4.9A)
None
5GP  A 125 (-2.6A)
5GP  A 125 (-3.7A)
5GP  A 125 (-4.7A)
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 0.53A 3o1cA-3oxkA:
17.7		 3o1cA-3oxkA:
41.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 10 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.37A 3o1cA-4eguA:
19.1		 3o1cA-4eguA:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		7 / 10 ILE A   6
PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
HIS A 103
 5GP  A 200 (-3.6A)
None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.2A)
5GP  A 200 (-4.1A)
 0.62A 3o1xA-3n1tA:
20.2		 3o1xA-3n1tA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		6 / 10 PHE A   7
ILE A  10
ASP A  31
SER A  33
LEU A  41
HIS A 103
 None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-4.7A)
5GP  A 200 (-4.2A)
5GP  A 200 (-4.1A)
 0.63A 3o1xA-3n1tA:
20.2		 3o1xA-3n1tA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		8 / 10 ILE A   6
PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
HIS A  99
HIS A 101
 None
5GP  A 125 (-4.9A)
None
5GP  A 125 (-2.6A)
5GP  A 125 (-3.7A)
5GP  A 125 (-4.7A)
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 0.53A 3o1xA-3oxkA:
17.8		 3o1xA-3oxkA:
41.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 10 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.37A 3o1xA-4eguA:
19.1		 3o1xA-4eguA:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		3 / 3 GLY A 113
ASP A 131
ASP A 157
 5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-2.7A)
 0.43A 3ou7C-3b89A:
13.6		 3ou7C-3b89A:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		7 / 10 ILE A   6
PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
HIS A 103
 5GP  A 200 (-3.6A)
None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.2A)
5GP  A 200 (-4.1A)
 0.67A 3qgzA-3n1tA:
20.4		 3qgzA-3n1tA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		7 / 10 PHE A   7
ILE A  10
ASP A  31
ILE A  32
SER A  33
LEU A  41
HIS A 103
 None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.7A)
5GP  A 200 (-4.2A)
5GP  A 200 (-4.1A)
 0.70A 3qgzA-3n1tA:
20.4		 3qgzA-3n1tA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		8 / 10 ILE A   6
PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
HIS A  99
HIS A 101
 None
5GP  A 125 (-4.9A)
None
5GP  A 125 (-2.6A)
5GP  A 125 (-3.7A)
5GP  A 125 (-4.7A)
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 0.53A 3qgzA-3oxkA:
17.7		 3qgzA-3oxkA:
41.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 10 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.36A 3qgzA-4eguA:
19.2		 3qgzA-4eguA:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 145
GLY A 147
THR A 149
 5GP  A1230 (-3.3A)
5GP  A1230 (-3.5A)
5GP  A1230 (-3.6A)
 0.24A 3si7B-2jbhA:
undetectable		 3si7B-2jbhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1g7c ELONGATION FACTOR
1-ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 115
THR A  23
THR A  24
SER A  21
 None
None
None
5GP  A 507 (-3.5A)
 1.13A 3snfA-1g7cA:
undetectable		 3snfA-1g7cA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 TYR A 297
HIS A 248
GLY A 247
ILE A  50
GLY A 242
 None
None
None
None
5GP  A1340 (-3.6A)
 1.06A 3sudB-2bwgA:
undetectable		 3sudB-2bwgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 159
VAL A 112
HIS A 157
 5GP  A 300 (-2.9A)
5GP  A 300 (-4.9A)
None
 0.95A 3tj7A-2jkyA:
undetectable		 3tj7A-2jkyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.30A 3u9fF-3rl3A:
undetectable		 3u9fF-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.21A 3u9fG-3rl3A:
undetectable		 3u9fG-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.25A 3u9fL-3rl3A:
undetectable		 3u9fL-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.24A 3u9fS-3rl3A:
undetectable		 3u9fS-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3lnc GUANYLATE KINASE
(Anaplasma
phagocytophilum) 		4 / 5 TYR A 165
VAL A  10
SER A 122
GLY A 108
 None
None
None
5GP  A 300 (-3.4A)
 1.45A 3v4tA-3lncA:
undetectable
3v4tD-3lncA:
undetectable		 3v4tA-3lncA:
19.91
3v4tD-3lncA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 11 GLY A 113
ASP A 131
ASP A 157
VAL A 158
LEU A 179
 5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-2.7A)
5GP  A 500 (-3.6A)
None
 0.77A 3v8vB-3b89A:
5.2		 3v8vB-3b89A:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 8 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLN A 448
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
None
 0.31A 4af0A-5tc3A:
56.5		 4af0A-5tc3A:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 8 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
5GP  A 600 (-3.1A)
 0.44A 4af0A-5tc3A:
56.5		 4af0A-5tc3A:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 8 SER A 279
ASN A 306
MET A 328
GLY A 449
GLN A 448
 None
5GP  A 600 (-3.2A)
None
5GP  A 600 ( 3.8A)
None
 1.15A 4af0A-5tc3A:
56.5		 4af0A-5tc3A:
64.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 10 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLN A 448
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
None
 0.29A 4af0B-5tc3A:
56.6		 4af0B-5tc3A:
64.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		7 / 10 ASP A 277
SER A 278
SER A 279
ASN A 306
ARG A 325
MET A 328
GLY A 418
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-3.1A)
None
5GP  A 600 (-3.1A)
 0.44A 4af0B-5tc3A:
56.6		 4af0B-5tc3A:
64.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 10 SER A 279
ASN A 306
MET A 328
GLY A 449
GLN A 448
 None
5GP  A 600 (-3.2A)
None
5GP  A 600 ( 3.8A)
None
 1.14A 4af0B-5tc3A:
56.6		 4af0B-5tc3A:
64.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 GLY A 195
GLY A 181
VAL A 160
CYH A 186
 None
K  A1339 (-4.8A)
None
5GP  A1340 ( 3.4A)
 0.89A 4c5nA-2bwgA:
undetectable		 4c5nA-2bwgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2klh C-MYC-RESPONSIVE
PROTEIN RCL
(Rattus
norvegicus) 		5 / 12 GLY A  89
TYR A  13
LEU A  73
HIS A  45
TYR A  28
 5GP  A 187 (-3.4A)
5GP  A 187 (-4.4A)
None
5GP  A 187 (-3.3A)
5GP  A 187 (-4.5A)
 1.46A 4emaA-2klhA:
undetectable		 4emaA-2klhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		4 / 6 PHE A  29
ILE A  15
PRO A  16
PHE A  27
 5GP  A 125 (-4.6A)
None
None
None
 1.20A 4fgkA-3oxkA:
undetectable		 4fgkA-3oxkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 178
LEU A 167
ALA A 122
ALA A 165
THR A 117
 None
None
None
None
5GP  A 300 (-3.7A)
 1.19A 4fiaA-2jkyA:
undetectable		 4fiaA-2jkyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 178
LEU A 167
ALA A 122
ALA A 165
THR A 117
 None
None
None
None
5GP  A 300 (-3.7A)
 1.19A 4fiaA-2jkyA:
undetectable		 4fiaA-2jkyA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 8 ASP A 277
SER A 278
SER A 279
ASN A 306
THR A 336
 None
None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-2.6A)
 0.88A 4fo4A-5tc3A:
47.9		 4fo4A-5tc3A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 8 SER A 278
SER A 279
ASN A 306
THR A 336
GLY A 418
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-3.1A)
 0.73A 4fo4A-5tc3A:
47.9		 4fo4A-5tc3A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ASN A 158
GLY A 181
CYH A 186
THR A 188
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
 0.87A 4fo4B-2bwgA:
41.5		 4fo4B-2bwgA:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 8 ASN A 158
GLY A 181
THR A 188
GLY A 290
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.1A)
 0.88A 4fo4B-2bwgA:
41.5		 4fo4B-2bwgA:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		6 / 8 SER A 278
SER A 279
ASN A 306
GLY A 329
THR A 336
GLY A 418
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-3.1A)
 0.63A 4fo4B-5tc3A:
47.8		 4fo4B-5tc3A:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 ASN A 158
GLY A 181
CYH A 186
THR A 188
ASP A 219
 5GP  A1340 ( 4.0A)
K  A1339 (-4.8A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-2.3A)
 0.75A 4fxsA-2bwgA:
41.6		 4fxsA-2bwgA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 9 ASP A 129
ASN A 158
CYH A 186
THR A 188
ASP A 219
 None
5GP  A1340 ( 4.0A)
5GP  A1340 ( 3.4A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-2.3A)
 0.80A 4fxsA-2bwgA:
41.6		 4fxsA-2bwgA:
29.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 9 ASP A 277
SER A 278
SER A 279
GLY A 329
THR A 336
 None
None
None
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
 0.69A 4fxsA-5tc3A:
50.5		 4fxsA-5tc3A:
39.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		6 / 9 SER A 278
SER A 279
ASN A 306
GLY A 329
THR A 336
ASP A 367
 None
None
5GP  A 600 (-3.2A)
5GP  A 600 ( 3.2A)
5GP  A 600 (-2.6A)
5GP  A 600 (-2.4A)
 0.55A 4fxsA-5tc3A:
50.5		 4fxsA-5tc3A:
39.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 5 HIS A  86
HIS A 219
HIS A 241
HIS A  91
 MN  A 301 (-3.4A)
5GP  A 303 (-4.1A)
MN  A 300 ( 3.4A)
MN  A 300 (-3.4A)
 0.97A 4h9mA-3py6A:
undetectable		 4h9mA-3py6A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A  81
ALA A 199
SER A 169
LEU A 170
VAL A 143
 CAS  A  82 ( 4.7A)
None
None
None
5GP  A1230 (-4.0A)
 1.11A 4or0A-2jbhA:
undetectable		 4or0A-2jbhA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 8 PRO A 163
LEU A 190
VAL A 201
LEU A 175
 None
None
None
5GP  A 500 ( 4.7A)
 0.87A 4pwdA-3b89A:
2.4		 4pwdA-3b89A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 ASP A 131
LEU A 155
LEU A  69
GLY A 135
ALA A  18
 5GP  A 500 (-3.1A)
None
None
None
None
 1.23A 4retA-3b89A:
2.2		 4retA-3b89A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		5 / 12 ASP A 131
LEU A 155
LEU A  69
GLY A 135
ALA A  18
 5GP  A 500 (-3.1A)
None
None
None
None
 1.23A 4retC-3b89A:
2.2		 4retC-3b89A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 128
ARG A 198
ARG A  93
 None
5GP  A 301 (-3.0A)
5GP  A 301 (-2.9A)
 0.98A 4x5iA-4o7zA:
undetectable		 4x5iA-4o7zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 116
ILE A 118
VAL A 106
THR A 101
 None
None
None
5GP  A 300 ( 4.8A)
 0.76A 4xdtA-1znxA:
undetectable		 4xdtA-1znxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 LEU A  20
ASP A 101
ILE A 170
 None
5GP  A1202 ( 3.4A)
None
 0.61A 4xi3D-1lvgA:
undetectable		 4xi3D-1lvgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  71
VAL A 112
ASP A 110
GLY A  39
 None
5GP  A 300 (-4.9A)
5GP  A 300 (-3.4A)
None
 1.03A 4xp6A-2jkyA:
undetectable		 4xp6A-2jkyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 8 ARG A 173
ASP A 167
VAL A  48
ASP A 105
 None
5GP  A 600 (-4.4A)
None
5GP  A 600 (-3.7A)
 1.16A 4xqgB-5esxA:
2.1		 4xqgB-5esxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		3 / 3 SER A  10
GLU A 157
ASP A 103
 None
None
5GP  A1202 (-3.8A)
 0.77A 4xudA-1lvgA:
undetectable		 4xudA-1lvgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 7 ARG A  44
TYR A  81
GLU A  47
ASP A  52
 5GP  A1202 (-3.1A)
5GP  A1202 (-3.8A)
None
None
 1.13A 4zz8A-1lvgA:
0.0		 4zz8A-1lvgA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 155
GLY A 180
ASP A 179
GLY A 147
 None
None
None
5GP  A1230 (-3.5A)
 0.86A 5cdnA-2jbhA:
undetectable
5cdnB-2jbhA:
2.7		 5cdnA-2jbhA:
19.27
5cdnB-2jbhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 155
GLY A 180
ASP A 179
GLY A 147
 None
None
None
5GP  A1230 (-3.5A)
 0.91A 5cdnR-2jbhA:
undetectable
5cdnS-2jbhA:
2.7		 5cdnR-2jbhA:
19.27
5cdnS-2jbhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 6 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.18A 5dzka-3py6A:
undetectable
5dzko-3py6A:
undetectable		 5dzka-3py6A:
23.96
5dzko-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 7 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.11A 5dzkD-3py6A:
undetectable
5dzkR-3py6A:
undetectable		 5dzkD-3py6A:
23.96
5dzkR-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 6 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.24A 5dzke-3py6A:
undetectable
5dzks-3py6A:
undetectable		 5dzke-3py6A:
23.96
5dzks-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 6 PHE A 220
SER A 218
HIS A 170
LEU A 211
 None
5GP  A 303 ( 4.3A)
MN  A 301 ( 3.4A)
None
 1.24A 5dzkg-3py6A:
undetectable
5dzku-3py6A:
undetectable		 5dzkg-3py6A:
23.96
5dzku-3py6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Tritrichomonas
suis) 		4 / 4 ASP A 163
GLY A  48
ASP A 103
ASP A 106
 None
None
5GP  A 600 (-2.8A)
5GP  A 600 (-4.2A)
 1.14A 5e72A-1hgxA:
2.2		 5e72A-1hgxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1pzm HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Leishmania
tarentolae) 		4 / 4 ASP A 185
GLY A  67
ASP A 126
ASP A 129
 5GP  A 301 (-4.6A)
None
5GP  A 301 (-3.5A)
5GP  A 301 (-4.7A)
 1.17A 5e72A-1pzmA:
undetectable		 5e72A-1pzmA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3acc HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 4 ASP A 162
GLY A  47
ASP A 103
ASP A 106
 5GP  A 817 (-4.6A)
None
5GP  A 817 (-3.0A)
5GP  A 817 (-4.2A)
 1.16A 5e72A-3accA:
undetectable		 5e72A-3accA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 4 ASP A 109
GLY A 113
ASP A 131
ASP A 157
 None
5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-2.7A)
 0.93A 5e72A-3b89A:
11.7		 5e72A-3b89A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		5 / 8 GLU A 119
HIS A  67
GLY A  85
HIS A 118
HIS A 254
 None
MN  A 444 ( 3.4A)
None
5GP  A 951 (-3.8A)
MN  A 444 ( 3.5A)
 1.24A 5f8yB-3rl3A:
undetectable		 5f8yB-3rl3A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  67
GLU A 194
TYR A 191
SER A  74
 MG  A 302 ( 3.8A)
5GP  A 300 (-2.7A)
5GP  A 300 (-4.6A)
None
 1.19A 5fhrA-2jkyA:
undetectable		 5fhrA-2jkyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 6 ILE A 118
TYR A 119
PHE A 165
THR A  83
 None
None
None
5GP  A1202 (-4.2A)
 1.24A 5g08A-1lvgA:
undetectable		 5g08A-1lvgA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Sulfolobus
solfataricus) 		5 / 12 MET A 215
LEU A 246
ALA A 289
GLU A 288
GLY A 298
 None
None
None
None
5GP  A   1 (-3.7A)
 1.12A 5gtrA-3penA:
undetectable		 5gtrA-3penA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 SER A 193
ASN A  49
GLU A 191
VAL A  91
GLU A  89
 None
None
None
5GP  A 301 ( 4.5A)
5GP  A 301 ( 3.9A)
 1.44A 5iqdC-4o7zA:
2.8		 5iqdC-4o7zA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE
(Legionella
pneumophila) 		4 / 6 VAL A 156
MET A 166
ILE A 107
ASP A 109
 None
None
5GP  A 600 (-4.2A)
5GP  A 600 (-4.0A)
 1.15A 5iwuA-5esxA:
undetectable		 5iwuA-5esxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 ALA A 206
TYR A 285
GLY A  59
THR A  74
MET A 240
 None
None
None
None
5GP  A1340 (-3.5A)
 1.32A 5jlcA-2bwgA:
undetectable		 5jlcA-2bwgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		5 / 12 ALA A 209
TYR A 285
GLY A  59
THR A  74
MET A 240
 None
None
None
None
5GP  A1340 (-3.5A)
 1.34A 5jlcA-2bwgA:
undetectable		 5jlcA-2bwgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A  27
VAL A 120
GLY A 124
ALA A 125
 None
None
5GP  A 300 ( 4.9A)
None
 1.09A 5k50A-1znxA:
2.1		 5k50A-1znxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Tritrichomonas
suis) 		5 / 12 ILE A 174
LEU A 131
PHE A 162
ARG A 169
GLY A 159
 None
None
5GP  A 600 ( 4.9A)
None
None
 1.35A 5k7uA-1hgxA:
undetectable		 5k7uA-1hgxA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 8 ASN A  86
ALA A  91
GLN A  93
HIS A  99
HIS A 101
 5GP  A 125 (-3.7A)
None
None
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 1.12A 5km8A-3oxkA:
15.2
5km8B-3oxkA:
18.2		 5km8A-3oxkA:
33.81
5km8B-3oxkA:
33.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		4 / 8 ASN A  89
GLN A  96
HIS A 102
HIS A 104
 5GP  A 201 ( 3.9A)
K  A 203 (-4.1A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.41A 5km8A-4eguA:
15.6
5km8B-4eguA:
18.9		 5km8A-4eguA:
30.00
5km8B-4eguA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		7 / 12 ILE A   6
PHE A   7
ILE A  10
ASP A  31
LEU A  41
VAL A  97
HIS A 103
 5GP  A 200 (-3.6A)
None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-4.2A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.1A)
 0.34A 5km9B-3n1tA:
20.2		 5km9B-3n1tA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		5 / 12 ILE A   6
ILE A  10
ASP A  31
LEU A  41
HIS A 101
 None
None
5GP  A 125 (-2.6A)
5GP  A 125 (-4.7A)
5GP  A 125 (-4.1A)
 0.51A 5km9B-3oxkA:
18.3		 5km9B-3oxkA:
33.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		7 / 12 PHE A   7
ILE A  10
ASP A  31
LEU A  41
VAL A  95
HIS A  99
HIS A 101
 5GP  A 125 (-4.9A)
None
5GP  A 125 (-2.6A)
5GP  A 125 (-4.7A)
None
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 0.48A 5km9B-3oxkA:
18.3		 5km9B-3oxkA:
33.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		8 / 12 ILE A   7
PHE A   8
ILE A  11
ASP A  32
LEU A  42
VAL A  98
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 (-3.8A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.51A 5km9B-4eguA:
19.0		 5km9B-4eguA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2fxv XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 12 GLY A 130
GLN A 131
VAL A 137
VAL A 166
LEU A 168
 5GP  A 200 (-3.4A)
None
None
None
None
 1.10A 5kocB-2fxvA:
undetectable		 5kocB-2fxvA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		4 / 8 ASP A 188
HIS A 241
HIS A 219
HIS A  86
 MN  A 300 (-2.5A)
MN  A 300 ( 3.4A)
5GP  A 303 (-4.1A)
MN  A 301 (-3.4A)
 0.92A 5nekD-3py6A:
undetectable		 5nekD-3py6A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3py6 BETA-LACTAMASE-LIKE
(Brucella
abortus) 		6 / 10 HIS A  86
HIS A  88
HIS A  91
HIS A 170
ASP A 188
HIS A 219
 MN  A 301 (-3.4A)
MN  A 301 ( 3.3A)
MN  A 300 (-3.4A)
MN  A 301 ( 3.4A)
MN  A 300 (-2.5A)
5GP  A 303 (-4.1A)
 0.29A 5nzwA-3py6A:
10.7		 5nzwA-3py6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		3 / 3 LYS A  96
HIS A  92
HIS A  97
 5GP  A1295 (-2.5A)
5GP  A1295 (-3.9A)
5GP  A1295 (-4.1A)
 1.40A 5oexC-1iybA:
0.0		 5oexC-1iybA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 154
ASP A 110
LEU A  99
 None
5GP  A 300 (-3.4A)
None
 0.76A 5uhbC-2jkyA:
undetectable		 5uhbC-2jkyA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 154
ASP A 110
LEU A 101
 None
5GP  A 300 (-3.4A)
None
 0.80A 5uhbC-2jkyA:
undetectable		 5uhbC-2jkyA:
11.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3n1t HIT-LIKE PROTEIN
HINT
(Escherichia
coli) 		7 / 12 PHE A   7
ILE A  10
ASP A  31
ILE A  32
LEU A  41
VAL A  97
HIS A 103
 None
None
5GP  A 200 (-2.3A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.2A)
5GP  A 200 (-3.6A)
5GP  A 200 (-4.1A)
 0.37A 5uvmB-3n1tA:
20.1		 5uvmB-3n1tA:
37.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3oxk PUTATIVE HISTIDINE
TRIAD FAMILY PROTEIN
(Entamoeba
histolytica) 		10 / 12 PHE A   7
ILE A  10
ASP A  31
ILE A  32
ASN A  33
LEU A  41
THR A  94
VAL A  95
HIS A  99
HIS A 101
 5GP  A 125 (-4.9A)
None
5GP  A 125 (-2.6A)
5GP  A 125 (-3.7A)
None
5GP  A 125 (-4.7A)
5GP  A 125 (-3.4A)
None
5GP  A 125 (-3.9A)
5GP  A 125 (-4.1A)
 0.49A 5uvmB-3oxkA:
18.0		 5uvmB-3oxkA:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		5 / 12 ASP A  32
ASN A  34
LEU A  42
HIS A 102
HIS A 104
 5GP  A 201 (-2.2A)
5GP  A 201 (-3.1A)
5GP  A 201 (-3.7A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.88A 5uvmB-4eguA:
20.2		 5uvmB-4eguA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4egu HISTIDINE TRIAD
(HIT) PROTEIN
(Clostridioides
difficile) 		7 / 12 PHE A   8
ILE A  11
ASP A  32
LEU A  42
VAL A  98
HIS A 102
HIS A 104
 5GP  A 201 (-4.4A)
None
5GP  A 201 (-2.2A)
5GP  A 201 (-3.7A)
5GP  A 201 (-3.8A)
5GP  A 201 ( 2.0A)
5GP  A 201 (-2.3A)
 0.34A 5uvmB-4eguA:
20.2		 5uvmB-4eguA:
36.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 8 SER A  37
PHE A 204
PHE A  89
PRO A  27
 None
None
5GP  A 296 (-3.9A)
None
 1.08A 5vkqB-1vczA:
undetectable
5vkqC-1vczA:
undetectable		 5vkqB-1vczA:
7.56
5vkqC-1vczA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 153
GLU A  89
LEU A 119
ARG A 103
ASP A 128
 None
5GP  A 301 ( 3.9A)
None
ACT  A 303 (-3.5A)
None
 1.42A 5vlmC-4o7zA:
undetectable		 5vlmC-4o7zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		6 / 12 GLY A 113
ASP A 131
ILE A 132
VAL A 158
LEU A 175
LEU A 179
 5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-4.1A)
5GP  A 500 (-3.6A)
5GP  A 500 ( 4.7A)
None
 0.92A 5wy0A-3b89A:
13.8		 5wy0A-3b89A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  37
VAL A 112
GLY A  39
GLY A  40
PRO A  43
 SO4  A 301 ( 4.1A)
5GP  A 300 (-4.9A)
None
None
None
 1.02A 5wyqA-2jkyA:
undetectable		 5wyqA-2jkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		3 / 3 GLY A 368
VAL A  79
MET A  76
 5GP  A 600 ( 3.4A)
None
5GP  A 600 ( 2.9A)
 0.55A 5ycpA-5tc3A:
undetectable		 5ycpA-5tc3A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1lvg GUANYLATE KINASE
(Mus
musculus) 		4 / 6 GLU A  47
ARG A  44
ASP A  49
ASP A 101
 None
5GP  A1202 (-3.1A)
None
5GP  A1202 ( 3.4A)
 1.17A 5zw4A-1lvgA:
undetectable		 5zw4A-1lvgA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 LYS A 191
GLY A 290
ASP A  56
MET A  55
 None
5GP  A1340 (-3.1A)
None
5GP  A1340 (-3.9A)
 1.44A 6ag0A-2bwgA:
7.9		 6ag0A-2bwgA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 2bwg GMP REDUCTASE I
(Homo
sapiens) 		4 / 7 LYS A 191
GLY A 290
ASP A  56
MET A  55
 None
5GP  A1340 (-3.1A)
None
5GP  A1340 (-3.9A)
 1.47A 6ag0C-2bwgA:
7.1		 6ag0C-2bwgA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Eremothecium
gossypii) 		5 / 12 LEU A 276
VAL A 353
ARG A 325
ILE A 326
ASP A 367
 None
None
5GP  A 600 (-3.1A)
None
5GP  A 600 (-2.4A)
 1.39A 6bxnA-5tc3A:
undetectable		 6bxnA-5tc3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3b89 16S RRNA METHYLASE
(Escherichia
coli) 		4 / 8 LEU A  91
LEU A  94
LEU A 114
GLY A 113
 None
None
None
5GP  A 500 ( 4.5A)
 0.90A 6ce2A-3b89A:
undetectable		 6ce2A-3b89A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 HIS A  67
GLN A  46
THR A  43
ASN A 330
HIS A 404
 POP  A 509 (-3.7A)
None
None
MLI  A 503 (-4.1A)
5GP  A 501 (-3.0A)
 1.49A 6exiC-4dwqA:
undetectable		 6exiC-4dwqA:
11.43