SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5GF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 7 HIS A 698
PHE A 673
ILE A 488
TRP A 423
 5GF  A1021 (-4.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.1A)
 1.22A 1tdnA-5hjrA:
undetectable		 1tdnA-5hjrA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.35A 2qmjA-5hjrA:
43.0		 2qmjA-5hjrA:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ASP A 451
ILE A 488
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.34A 2qmjA-5hjrA:
43.0		 2qmjA-5hjrA:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 6 TRP A 562
MET A 565
TRP A 637
THR A 642
 5GF  A1021 (-4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
None
 0.39A 2qmjA-5hjrA:
43.1		 2qmjA-5hjrA:
30.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		6 / 12 ASP A 305
ASP A 451
ASP A 564
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.47A 2x2iA-5hjrA:
36.1		 2x2iA-5hjrA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 6 TRP A 562
MET A 565
ARG A 624
TRP A 637
 5GF  A1021 (-4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
 0.63A 2x2iA-5hjrA:
36.1		 2x2iA-5hjrA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ASP A 451
ASP A 564
MET A 565
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.50A 2x2iB-5hjrA:
33.7		 2x2iB-5hjrA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ASP A 451
ASP A 564
MET A 565
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.42A 2x2iC-5hjrA:
36.1		 2x2iC-5hjrA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ASP A 451
ASP A 564
MET A 565
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.43A 2x2iD-5hjrA:
33.5		 2x2iD-5hjrA:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 564
MET A 565
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.65A 3l4wA-5hjrA:
42.8		 3l4wA-5hjrA:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 562
ASP A 564
MET A 565
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.46A 3l4wA-5hjrA:
42.8		 3l4wA-5hjrA:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 ASP A 305
ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 564
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.46A 3phaA-5hjrA:
36.6		 3phaA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 490
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 ( 4.6A)
 1.22A 3phaA-5hjrA:
36.6		 3phaA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 305
ARG A 624
ASP A 564
HIS A 492
 5GF  A1021 (-2.6A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.1A)
None
 1.50A 3phaA-5hjrA:
36.6		 3phaA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.40A 3phaB-5hjrA:
41.7		 3phaB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ASP A 451
ILE A 488
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.25A 3phaB-5hjrA:
41.7		 3phaB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 490
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 ( 4.6A)
 1.20A 3phaB-5hjrA:
41.7		 3phaB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 305
ARG A 624
ASP A 564
HIS A 492
 5GF  A1021 (-2.6A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.1A)
None
 1.42A 3phaB-5hjrA:
41.7		 3phaB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 490
ILE A 488
ILE A 452
ASP A 305
 5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
None
5GF  A1021 (-3.6A)
None
 1.30A 3phaB-5hjrA:
41.7		 3phaB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 452
TRP A 525
ASP A 564
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.41A 3phaC-5hjrA:
41.2		 3phaC-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ASP A 451
ILE A 488
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.18A 3phaC-5hjrA:
41.2		 3phaC-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 305
ARG A 624
ASP A 564
HIS A 492
 5GF  A1021 (-2.6A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.1A)
None
 1.50A 3phaC-5hjrA:
41.2		 3phaC-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 452
TRP A 525
ASP A 564
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.33A 3phaD-5hjrA:
41.5		 3phaD-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ASP A 451
ILE A 488
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.19A 3phaD-5hjrA:
41.5		 3phaD-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 305
ARG A 624
ASP A 564
HIS A 492
 5GF  A1021 (-2.6A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.1A)
None
 1.45A 3phaD-5hjrA:
41.5		 3phaD-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 451
ILE A 488
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.24A 3pocA-5hjrA:
41.2		 3pocA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 525
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.48A 3pocA-5hjrA:
41.2		 3pocA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.89A 3pocA-5hjrA:
41.2		 3pocA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 451
ILE A 488
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.25A 3pocB-5hjrA:
42.9		 3pocB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 525
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.49A 3pocB-5hjrA:
42.9		 3pocB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.92A 3pocB-5hjrA:
42.9		 3pocB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 ASP A 305
ASP A 451
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
ASP A 640
PHE A 673
PHE A 674
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.0A)
 0.48A 3topA-5hjrA:
41.9		 3topA-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 305
TRP A 525
MET A 565
ASP A 640
PHE A 673
 None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
 1.36A 3topA-5hjrA:
41.9		 3topA-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 305
ARG A 624
ASP A 564
HIS A 492
 5GF  A1021 (-2.6A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.1A)
None
 1.45A 3topA-5hjrA:
41.9		 3topA-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 5 ILE A 452
TRP A 562
TRP A 637
THR A 642
 5GF  A1021 (-3.6A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
None
 0.38A 3topA-5hjrA:
41.9		 3topA-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.47A 3topB-5hjrA:
41.9		 3topB-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 640
ASP A 305
ARG A 624
ASP A 564
HIS A 492
 5GF  A1021 (-2.6A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.1A)
None
 1.43A 3topB-5hjrA:
41.9		 3topB-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 5 ILE A 452
TRP A 562
TRP A 637
PHE A 674
 5GF  A1021 (-3.6A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
None
 0.35A 3topB-5hjrA:
41.9		 3topB-5hjrA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ASP A 451
ILE A 452
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.46A 3w37A-5hjrA:
41.2		 3w37A-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 488
TRP A 562
ASP A 564
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.27A 3w37A-5hjrA:
41.2		 3w37A-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 305
TRP A 423
ASP A 640
PHE A 674
HIS A 700
 None
5GF  A1021 (-3.1A)
5GF  A1021 (-2.6A)
None
FMT  A1020 (-3.9A)
 1.46A 3w37A-5hjrA:
41.2		 3w37A-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 5 TRP A 423
ILE A 452
TRP A 525
TRP A 637
 5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
5GF  A1021 (-3.7A)
5GF  A1021 ( 4.6A)
 0.39A 3w37A-5hjrA:
41.2		 3w37A-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ASP A 451
ILE A 452
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.45A 3welA-5hjrA:
41.1		 3welA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 305
ASP A 451
ILE A 488
TRP A 562
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.28A 3welA-5hjrA:
41.1		 3welA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 6 TRP A 423
ILE A 452
TRP A 525
MET A 565
TRP A 637
 5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
5GF  A1021 (-3.7A)
5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
 0.35A 3welA-5hjrA:
41.2		 3welA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 305
ASP A 451
ILE A 452
ASP A 564
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.31A 3wemA-5hjrA:
40.9		 3wemA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ASP A 451
ILE A 488
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.28A 3wemA-5hjrA:
40.9		 3wemA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 5 TRP A 423
TRP A 525
TRP A 562
TRP A 637
 5GF  A1021 (-3.1A)
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
 0.54A 3wemA-5hjrA:
40.9		 3wemA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 452
TRP A 562
ASP A 564
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.31A 3wenA-5hjrA:
40.9		 3wenA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ASP A 451
ILE A 488
MET A 565
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.29A 3wenA-5hjrA:
40.9		 3wenA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 305
TRP A 423
ASP A 640
PHE A 674
HIS A 700
 None
5GF  A1021 (-3.1A)
5GF  A1021 (-2.6A)
None
FMT  A1020 (-3.9A)
 1.44A 3wenA-5hjrA:
40.9		 3wenA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 305
ASP A 451
ILE A 452
TRP A 562
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.26A 3weoA-5hjrA:
50.2		 3weoA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ASP A 451
ILE A 488
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.30A 3weoA-5hjrA:
50.2		 3weoA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 6 TRP A 423
ILE A 488
TRP A 525
MET A 565
TRP A 637
 5GF  A1021 (-3.1A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
 0.43A 3weoA-5hjrA:
50.1		 3weoA-5hjrA:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 451
ILE A 452
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.35A 4b9zA-5hjrA:
38.0		 4b9zA-5hjrA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 451
ILE A 488
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.30A 4b9zA-5hjrA:
38.0		 4b9zA-5hjrA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 451
ILE A 488
ASP A 564
GLU A 567
ARG A 624
ASP A 640
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
None
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-4.0A)
 1.50A 4b9zA-5hjrA:
38.0		 4b9zA-5hjrA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 6 ASP A 564
ASN A 566
ALA A 625
ASP A 640
 5GF  A1021 (-2.1A)
None
None
5GF  A1021 (-2.6A)
 1.20A 4mdbA-5hjrA:
undetectable		 4mdbA-5hjrA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		3 / 3 ASP A 490
TYR A 460
TRP A 562
 5GF  A1021 ( 4.6A)
None
5GF  A1021 (-4.6A)
 1.25A 4p7nA-5hjrA:
6.8		 4p7nA-5hjrA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 562
ASP A 564
MET A 565
PHE A 571
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.31A 5iefA-5hjrA:
61.4		 5iefA-5hjrA:
93.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 4 ARG A 624
TRP A 637
ASP A 669
ARG A 696
 5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 ( 4.6A)
None
 0.22A 5iefA-5hjrA:
61.4		 5iefA-5hjrA:
93.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 TRP A 423
ASP A 451
ILE A 488
TRP A 525
TRP A 562
ASP A 564
MET A 565
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.80A 5nn6A-5hjrA:
42.3		 5nn6A-5hjrA:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 TRP A 423
ASP A 451
ILE A 488
TRP A 562
ASP A 564
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
None
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.47A 5nn6A-5hjrA:
42.3		 5nn6A-5hjrA:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 305
ASP A 451
ILE A 452
ASP A 640
PHE A 673
 None
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
 1.50A 5nn8A-5hjrA:
30.7		 5nn8A-5hjrA:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ASP A 451
ILE A 488
TRP A 525
TRP A 562
ASP A 564
ARG A 624
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.0A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.41A 5nn8A-5hjrA:
30.7		 5nn8A-5hjrA:
32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		5 / 12 ASP A 305
ASP A 669
ASP A 640
ASP A 564
HIS A 698
 None
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-4.0A)
 1.41A 5nn8A-5hjrA:
30.7		 5nn8A-5hjrA:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 10 TRP A 562
ASP A 564
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-4.6A)
5GF  A1021 (-2.1A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.55A 5x7pA-5hjrA:
34.4		 5x7pA-5hjrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ILE A 488
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.07A 6c9xA-5hjrA:
36.7		 6c9xA-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 ASP A 305
TRP A 423
ILE A 452
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.53A 6c9xA-5hjrA:
36.7		 6c9xA-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 TRP A 423
ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.94A 6c9xA-5hjrA:
36.7		 6c9xA-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 305
ILE A 488
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.07A 6c9xB-5hjrA:
36.6		 6c9xB-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 ASP A 305
TRP A 423
ILE A 452
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.54A 6c9xB-5hjrA:
36.6		 6c9xB-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 TRP A 423
ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.94A 6c9xB-5hjrA:
36.6		 6c9xB-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ILE A 452
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.46A 6c9zA-5hjrA:
35.4		 6c9zA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.98A 6c9zA-5hjrA:
35.4		 6c9zA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ILE A 488
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.02A 6c9zA-5hjrA:
35.4		 6c9zA-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 305
ILE A 452
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.47A 6c9zB-5hjrA:
36.5		 6c9zB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 305
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.08A 6c9zB-5hjrA:
36.5		 6c9zB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.97A 6c9zB-5hjrA:
36.5		 6c9zB-5hjrA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 451
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.20A 6ca1A-5hjrA:
41.1		 6ca1A-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.53A 6ca1A-5hjrA:
41.1		 6ca1A-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.87A 6ca1A-5hjrA:
41.1		 6ca1A-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 451
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.21A 6ca1B-5hjrA:
39.8		 6ca1B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		11 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.48A 6ca1B-5hjrA:
39.8		 6ca1B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 TRP A 423
ASP A 451
ILE A 452
ILE A 488
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.85A 6ca1B-5hjrA:
39.8		 6ca1B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 451
ILE A 452
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.50A 6ca3A-5hjrA:
36.2		 6ca3A-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.94A 6ca3A-5hjrA:
36.2		 6ca3A-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 451
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.19A 6ca3A-5hjrA:
36.2		 6ca3A-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		10 / 12 ASP A 451
ILE A 452
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.51A 6ca3B-5hjrA:
35.4		 6ca3B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		8 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 525
ASP A 564
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.81A 6ca3B-5hjrA:
35.4		 6ca3B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		7 / 12 ASP A 451
ILE A 452
ILE A 488
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.94A 6ca3B-5hjrA:
35.4		 6ca3B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		9 / 12 ASP A 451
ILE A 488
ASP A 564
MET A 565
ARG A 624
TRP A 637
ASP A 640
PHE A 673
HIS A 698
 5GF  A1021 (-2.0A)
None
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.20A 6ca3B-5hjrA:
35.4		 6ca3B-5hjrA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB
(Mus
musculus) 		4 / 5 PHE A 571
PRO A 568
MET A 565
VAL A 576
 None
None
5GF  A1021 (-2.6A)
None
 1.33A 6ekzA-5hjrA:
undetectable		 6ekzA-5hjrA:
8.29