SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5CP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		7 / 12 VAL A  28
ALA A  41
VAL A  74
VAL A  93
ASN A 141
LEU A 143
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 3.7A)
None
5CP  A 600 (-4.4A)
5CP  A 600 (-3.5A)
 0.74A 1fmoE-3bhhA:
22.8		 1fmoE-3bhhA:
29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		7 / 12 VAL A  28
PHE A  90
VAL A  93
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 ( 4.3A)
5CP  A 600 ( 3.7A)
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.74A 2eufB-3bhhA:
27.4		 2eufB-3bhhA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		7 / 12 VAL A  28
VAL A  74
PHE A  90
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.62A 2eufB-3bhhA:
27.4		 2eufB-3bhhA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		4 / 8 ALA A  41
GLU A  61
LEU A  88
LEU A  92
 5CP  A 600 (-3.6A)
None
None
5CP  A 600 (-4.6A)
 0.42A 3lfaA-3bhhA:
22.1		 3lfaA-3bhhA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		3 / 3 GLU A  61
LEU A  88
LEU A  92
 None
None
5CP  A 600 (-4.6A)
 0.62A 3ohtA-3bhhA:
5.9		 3ohtA-3bhhA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		3 / 3 GLU A  61
LEU A  88
LEU A  92
 None
None
5CP  A 600 (-4.6A)
 0.65A 3ohtB-3bhhA:
5.8		 3ohtB-3bhhA:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		5 / 9 ALA A  41
VAL A  74
PHE A  90
LEU A 143
ASP A 157
 5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
5CP  A 600 (-4.4A)
5CP  A 600 (-3.5A)
 0.77A 3ti1A-3bhhA:
23.7		 3ti1A-3bhhA:
31.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
ILE A  64
LEU A 143
ALA A 156
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
None
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
 0.86A 4bkjA-3bhhA:
23.0		 4bkjA-3bhhA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
ILE A  64
LEU A 143
ALA A 156
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
None
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
 0.84A 4bkjB-3bhhA:
22.9		 4bkjB-3bhhA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		6 / 12 VAL A  28
ALA A  41
GLU A  61
CYH A 127
HIS A 134
ALA A 156
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
None
None
None
5CP  A 600 ( 3.9A)
 1.27A 4v04A-3bhhA:
22.6		 4v04A-3bhhA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		7 / 12 VAL A  28
ALA A  41
VAL A  74
PHE A  90
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.63A 5l2iA-3bhhA:
7.6		 5l2iA-3bhhA:
30.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		7 / 12 VAL A  28
ALA A  41
VAL A  74
PHE A  90
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.77A 5l2tA-3bhhA:
7.4		 5l2tA-3bhhA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN
(Homo
sapiens) 		4 / 4 VAL A  74
LEU A  92
ASN A 141
ASP A 157
 5CP  A 600 ( 4.7A)
5CP  A 600 (-4.6A)
None
5CP  A 600 (-3.5A)
 0.86A 5vcyA-3bhhA:
25.3		 5vcyA-3bhhA:
26.35