SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5AD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 137
SER A 183
SER A 185
THR A 187
 5AD  A1746 ( 3.9A)
None
EDO  A1754 (-3.2A)
None
 0.69A 1dvxA-2xijA:
undetectable		 1dvxA-2xijA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT
(Acetoanaerobium
sticklandii) 		5 / 12 PRO A 124
THR A 133
ILE A 108
GLY A 129
GLY A 126
 5AD  A1500 ( 4.8A)
None
None
None
None
 0.98A 1nv8A-3koyA:
undetectable		 1nv8A-3koyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT
(Acetoanaerobium
sticklandii) 		5 / 12 PRO A 124
THR A 133
ILE A 108
GLY A 129
GLY A 126
 5AD  A1500 ( 4.8A)
None
None
None
None
 0.97A 1sg9B-3koyA:
undetectable		 1sg9B-3koyA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
(Acetoanaerobium
sticklandii) 		3 / 3 PRO A  57
ASP A  52
ASP A  64
 None
None
5AD  B 500 ( 4.7A)
 0.68A 1sqfA-1xrsA:
undetectable		 1sqfA-1xrsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 8 CYH A 132
GLU A 180
SER A 233
VAL A 280
 SF4  A 502 ( 2.2A)
MET  A 501 (-4.0A)
MET  A 501 ( 2.6A)
5AD  A 503 (-4.8A)
 0.69A 2fb2A-5hr6A:
12.2		 2fb2A-5hr6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 12 GLY A 138
GLY A 141
ASP A 119
THR A 122
ALA A 491
 None
5AD  A 803 ( 4.1A)
None
None
None
 1.01A 2gluA-4r3uA:
undetectable		 2gluA-4r3uA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4
(Streptoalloteich
us
tenebrarius) 		5 / 11 SER B 308
ILE B 357
SER B 356
ALA B 424
ILE B 379
 None
None
None
None
5AD  B 504 ( 4.8A)
 1.03A 2nnhA-6fd2B:
undetectable		 2nnhA-6fd2B:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 10 ASP A 880
SER A 624
LEU A 885
THR A 884
GLY A 868
 None
BCO  A1103 (-3.4A)
None
None
5AD  A1102 ( 3.5A)
 1.33A 2v0mA-5cjuA:
undetectable		 2v0mA-5cjuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_B_TC9B1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4
(Streptoalloteich
us
tenebrarius) 		5 / 11 TYR B 382
TYR B 216
GLN B  23
SER B  85
SER B 111
 5AD  B 504 (-4.8A)
D5E  B 501 ( 4.5A)
None
None
None
 1.30A 2xytB-6fd2B:
0.0
2xytC-6fd2B:
0.0
2xytG-6fd2B:
0.0		 2xytB-6fd2B:
17.86
2xytC-6fd2B:
17.86
2xytG-6fd2B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		3 / 3 CYH A 331
HIS A 366
PHE A 288
 None
5AD  A 803 ( 4.8A)
3KK  A 802 ( 4.1A)
 1.20A 3cr4X-4r3uA:
undetectable		 3cr4X-4r3uA:
9.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		10 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
HIS A 235
VAL A 280
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.64A 3rfaA-5hr6A:
50.5		 3rfaA-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		10 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 213
HIS A 235
VAL A 280
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 ( 3.3A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.76A 3rfaA-5hr6A:
50.5		 3rfaA-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		9 / 12 PHE A 131
CYH A 132
MET A 176
HIS A 235
GLU A 278
VAL A 280
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.92A 3rfaA-5hr6A:
50.5		 3rfaA-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		8 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 213
TRP A 311
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 3.3A)
5AD  A 503 (-4.0A)
 0.58A 3rfaB-5hr6A:
52.8		 3rfaB-5hr6A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		11 / 12 PHE A 131
CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
VAL A 280
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.31A 3rfaB-5hr6A:
52.8		 3rfaB-5hr6A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		3 / 3 PHE A 131
SER A 213
SER A 233
 5AD  A 503 (-4.6A)
MET  A 501 ( 3.3A)
MET  A 501 ( 2.6A)
 0.95A 3ufgB-5hr6A:
undetectable		 3ufgB-5hr6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		5 / 11 CYH A 132
GLU A 180
SER A 233
VAL A 280
ILE A 309
 SF4  A 502 ( 2.2A)
MET  A 501 (-4.0A)
MET  A 501 ( 2.6A)
5AD  A 503 (-4.8A)
5AD  A 503 (-4.1A)
 0.52A 4k37A-5hr6A:
4.2		 4k37A-5hr6A:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		10 / 11 PHE A 131
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.46A 4pl1A-5hr6A:
49.5		 4pl1A-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		7 / 11 PHE A 131
MET A 176
HIS A 235
GLU A 278
ILE A 309
TRP A 311
ASN A 312
 5AD  A 503 (-4.6A)
A  C  37 ( 3.7A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.88A 4pl1A-5hr6A:
49.5		 4pl1A-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_B_SAMB401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		9 / 10 CYH A 132
MET A 176
GLU A 180
PRO A 181
SER A 211
SER A 233
HIS A 235
TRP A 311
ASN A 312
 SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 (-4.0A)
MET  A 501 ( 4.9A)
MET  A 501 (-2.5A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.41A 4pl1B-5hr6A:
51.9		 4pl1B-5hr6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PL1_B_SAMB401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		7 / 10 CYH A 132
MET A 176
SER A 233
HIS A 235
GLU A 278
TRP A 311
ASN A 312
 SF4  A 502 ( 2.2A)
A  C  37 ( 3.7A)
MET  A 501 ( 2.6A)
5AD  A 503 (-3.7A)
5AD  A 503 (-3.1A)
5AD  A 503 (-4.0A)
SMC  A 355 (-3.7A)
 0.85A 4pl1B-5hr6A:
51.9		 4pl1B-5hr6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4
(Streptoalloteich
us
tenebrarius) 		3 / 3 ARG B 319
GLU B 352
TYR B 213
 None
None
5AD  B 504 (-4.5A)
 0.73A 4r29D-6fd2B:
undetectable		 4r29D-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 THR A  99
GLY A 141
ALA A 143
ASP A 145
SER A 128
 None
5AD  A 803 ( 4.1A)
None
None
None
 1.44A 5l66K-4r3uA:
undetectable
5l66L-4r3uA:
undetectable		 5l66K-4r3uA:
20.82
5l66L-4r3uA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT
(Aquincola
tertiaricarbonis) 		5 / 10 THR A  99
GLY A 141
ALA A 143
ASP A 145
SER A 128
 None
5AD  A 803 ( 4.1A)
None
None
None
 1.45A 5l66Y-4r3uA:
undetectable
5l66Z-4r3uA:
undetectable		 5l66Y-4r3uA:
20.82
5l66Z-4r3uA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		3 / 3 SER A 213
SER A 211
PHE A 131
 MET  A 501 ( 3.3A)
MET  A 501 (-2.5A)
5AD  A 503 (-4.6A)
 0.94A 5mugA-5hr6A:
3.8		 5mugA-5hr6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5hr6 RLMN METHYLASE
(Escherichia
coli) 		4 / 5 HIS A 235
VAL A 246
PHE A 257
ARG A 242
 5AD  A 503 (-3.7A)
None
None
None
 1.37A 6hxiB-5hr6A:
undetectable		 6hxiB-5hr6A:
21.68