SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '59B'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 7 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
 0.16A 1dmaA-5dczA:
6.1		 1dmaA-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 7 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.75A 1dmaA-5dczA:
6.1		 1dmaA-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		5 / 6 HIS A1031
GLY A1032
TYR A1060
ALA A1062
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-3.3A)
 0.35A 1dmaB-5dczA:
5.5		 1dmaB-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.55A 1dmaB-5dczA:
5.5		 1dmaB-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 7 ALA A1135
ARG A 980
TYR A1050
TYR A1060
 None
PO4  A1202 (-4.9A)
59B  A1203 ( 4.3A)
59B  A1203 (-4.3A)
 1.20A 2ajvH-5dczA:
undetectable
2ajvL-5dczA:
undetectable		 2ajvH-5dczA:
21.54
2ajvL-5dczA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5dcz TANKYRASE-2
(Homo
sapiens) 		5 / 12 TYR A1071
ILE A1051
GLY A1052
GLY A1053
ILE A1075
 59B  A1203 (-3.3A)
None
None
None
59B  A1203 (-4.8A)
 1.04A 3jayA-5dczA:
undetectable		 3jayA-5dczA:
12.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		8 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.23A 3u9hA-5dczA:
37.4		 3u9hA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		8 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.23A 3u9hB-5dczA:
37.2		 3u9hB-5dczA:
96.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
 0.29A 4ae1A-5dczA:
6.8		 4ae1A-5dczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.77A 4ae1A-5dczA:
6.8		 4ae1A-5dczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 5 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
 0.31A 4ae1B-5dczA:
5.0		 4ae1B-5dczA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 5 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.76A 4ae1B-5dczA:
5.0		 4ae1B-5dczA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		8 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.21A 4bjcA-5dczA:
34.5		 4bjcA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 7 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.90A 4hyfA-5dczA:
32.9		 4hyfA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 7 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.44A 4hyfA-5dczA:
32.9		 4hyfA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.90A 4hyfB-5dczA:
32.9		 4hyfB-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		7 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.50A 4hyfB-5dczA:
32.9		 4hyfB-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		5 / 8 HIS A1031
GLY A1032
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.78A 4hyfC-5dczA:
32.4		 4hyfC-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.46A 4hyfC-5dczA:
32.4		 4hyfC-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
TYR A1060
LYS A1067
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 1.08A 4hyfC-5dczA:
32.4		 4hyfC-5dczA:
96.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.91A 4rv6A-5dczA:
19.4		 4rv6A-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
 1.11A 4rv6A-5dczA:
19.4		 4rv6A-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.43A 4rv6A-5dczA:
19.4		 4rv6A-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.91A 4rv6B-5dczA:
19.4		 4rv6B-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
 1.11A 4rv6B-5dczA:
19.4		 4rv6B-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.42A 4rv6B-5dczA:
19.4		 4rv6B-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 9 HIS A1031
SER A1033
ILE A1039
TYR A1060
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
None
59B  A1203 (-4.3A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.65A 5ha9B-5dczA:
17.4		 5ha9B-5dczA:
22.47