SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '58K'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 12 GLY B 213
LEU B 159
LEU B 124
LEU B 225
HIS B 134
 AKG  B 402 (-2.9A)
AKG  B 402 (-4.4A)
None
None
58K  B 403 (-3.4A)
 1.25A 1mx1C-5y7rB:
undetectable		 1mx1C-5y7rB:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 10 LEU B 225
HIS B 134
ASP B 136
ILE B 205
HIS B 211
 None
58K  B 403 (-3.4A)
FE  B 401 (-2.6A)
None
FE  B 401 ( 3.3A)
 0.77A 3kcxA-5y7rB:
11.3		 3kcxA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 5 LEU B 226
ALA B 202
PHE B  38
ASN B 157
 None
None
None
58K  B 403 ( 3.7A)
 1.37A 3uq6A-5y7rB:
undetectable		 3uq6A-5y7rB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 4 LEU B 226
ALA B 202
PHE B  38
ASN B 157
 None
None
None
58K  B 403 ( 3.7A)
 1.25A 3vaqA-5y7rB:
undetectable		 3vaqA-5y7rB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 4 LEU B 226
ALA B 202
PHE B  38
ASN B 157
 None
None
None
58K  B 403 ( 3.7A)
 1.29A 3vasA-5y7rB:
undetectable		 3vasA-5y7rB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 7 ASP B 136
LEU B 238
ASN B  70
LEU B  79
 FE  B 401 (-2.6A)
None
58K  B 403 (-3.5A)
58K  B 403 (-4.6A)
 1.13A 4ib4A-5y7rB:
undetectable		 4ib4A-5y7rB:
11.90