SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '56S'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  97
THR A  86
PHE A 142
 None
None
56S  A 305 (-4.1A)
 0.53A 2c6nB-5d1rA:
undetectable		 2c6nB-5d1rA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 133
PHE A 170
GLY A 140
PHE A 143
 None
None
None
56S  A 305 ( 3.5A)
 0.76A 3ko0O-5d1rA:
undetectable
3ko0Q-5d1rA:
undetectable		 3ko0O-5d1rA:
17.07
3ko0Q-5d1rA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 180
PHE A 179
LEU A 192
VAL A 228
ALA A 148
 None
None
56S  A 305 ( 4.3A)
None
None
 1.19A 4a84A-5d1rA:
undetectable		 4a84A-5d1rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 142
ASP A 144
ARG A  83
 56S  A 305 (-4.1A)
None
None
 0.84A 4eahF-5d1rA:
undetectable		 4eahF-5d1rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 142
ASP A 144
ARG A  83
 56S  A 305 (-4.1A)
None
None
 0.83A 4eahG-5d1rA:
undetectable		 4eahG-5d1rA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 227
PHE A 190
PHE A 143
PHE A 177
 None
56S  A 305 (-3.0A)
56S  A 305 ( 3.5A)
None
 0.97A 6h7lA-5d1rA:
undetectable		 6h7lA-5d1rA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5d1r RV1816
TRANSCRIPTIONAL
REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 227
PHE A 190
PHE A 143
PHE A 177
 None
56S  A 305 (-3.0A)
56S  A 305 ( 3.5A)
None
 0.98A 6h7lB-5d1rA:
undetectable		 6h7lB-5d1rA:
16.32