SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '55X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 156
ILE A  75
MET A  96
TRP A 164
 None
None
None
55X  A 201 (-4.0A)
 0.99A 3welA-5cw8A:
undetectable		 3welA-5cw8A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR
(Mycobacterium
tuberculosis) 		4 / 5 SER A 161
MET A 144
LEU A  93
PHE A 140
 55X  A 201 (-3.8A)
None
None
None
 1.27A 5evyX-5cw8A:
undetectable		 5evyX-5cw8A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5cw8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 168
MET A 104
LEU A 185
ASN A 101
ILE A 160
 None
55X  A 201 (-4.3A)
None
None
None
 1.43A 5mzjA-5cw8A:
4.7		 5mzjA-5cw8A:
18.18