SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '51W'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ALA A  44
LYS A  46
GLU A  63
LEU A  90
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.81A 1m17A-5ci7A:
26.0		 1m17A-5ci7A:
27.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 6 ILE A  22
VAL A  30
ILE A  75
ILE A 134
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
None
None
 0.71A 1uwhA-5ci7A:
23.8		 1uwhA-5ci7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 ILE A  22
VAL A  30
ALA A  44
CYH A  95
LEU A 129
HIS A 136
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
None
None
 0.92A 1uwjB-5ci7A:
22.7		 1uwjB-5ci7A:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 ALA A  44
GLY A  98
ASP A 102
LEU A 145
ASP A 165
PHE A 166
 51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
None
 0.94A 1xkkA-5ci7A:
22.7		 1xkkA-5ci7A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 VAL A  30
VAL A  76
ASP A  99
ASN A 143
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
None
51W  A 401 (-3.8A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
None
 0.49A 2eufB-5ci7A:
27.1		 2eufB-5ci7A:
29.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 11 GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.69A 2evaA-5ci7A:
24.2		 2evaA-5ci7A:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
LYS A 140
ASN A 143
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
None
GOL  A 404 ( 4.6A)
 0.71A 2fumB-5ci7A:
27.5		 2fumB-5ci7A:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
ASN A 143
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
GOL  A 404 ( 4.6A)
GOL  A 404 (-3.2A)
 0.66A 2fumC-5ci7A:
26.2		 2fumC-5ci7A:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
GLY A  25
VAL A  30
ALA A  44
MET A  92
ASN A 143
ASP A 165
 51W  A 401 (-3.3A)
GOL  A 404 ( 3.2A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
GOL  A 404 ( 4.6A)
GOL  A 404 (-3.2A)
 0.82A 2fumD-5ci7A:
26.1		 2fumD-5ci7A:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  44
MET A  92
LYS A 140
ASN A 143
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
None
GOL  A 404 ( 4.6A)
GOL  A 404 (-3.2A)
 0.72A 2fumD-5ci7A:
26.1		 2fumD-5ci7A:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  44
VAL A  76
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.50A 2hyyC-5ci7A:
23.2		 2hyyC-5ci7A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 ALA A  44
LYS A  46
GLU A  63
LEU A  90
GLY A  98
LEU A 145
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.73A 2itoA-5ci7A:
19.1		 2itoA-5ci7A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		9 / 12 GLY A  23
VAL A  30
LYS A  46
GLU A  63
LEU A  67
LEU A  90
TYR A  94
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
GOL  A 404 ( 3.1A)
None
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.66A 2ivuA-5ci7A:
28.6		 2ivuA-5ci7A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 GLY A  23
VAL A  30
ALA A  44
TYR A  94
GLY A  98
ALA A 164
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
None
 0.70A 2wgjA-5ci7A:
23.1		 2wgjA-5ci7A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ILE A  22
ALA A  44
LYS A  46
GLU A  63
TYR A  94
GLY A  98
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.78A 2y6oA-5ci7A:
23.7		 2y6oA-5ci7A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 ILE A  22
VAL A  30
ALA A  44
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.69A 2y7jA-5ci7A:
30.8		 2y7jA-5ci7A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 10 ILE A  22
VAL A  30
ALA A  44
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.79A 2y7jB-5ci7A:
26.7		 2y7jB-5ci7A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 10 ILE A  22
VAL A  30
ALA A  44
GLY A  98
ASP A 102
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.68A 2y7jC-5ci7A:
27.5		 2y7jC-5ci7A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  44
LEU A  90
GLY A  98
LEU A 145
ASP A 165
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
None
 0.90A 3bbtD-5ci7A:
22.5		 3bbtD-5ci7A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  44
LYS A  46
LEU A  90
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 1.06A 3bbtD-5ci7A:
22.5		 3bbtD-5ci7A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
ALA A  44
LYS A  46
VAL A  76
CYH A  95
GLY A  98
LEU A 145
 51W  A 401 (-3.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.64A 3c7qA-5ci7A:
22.8		 3c7qA-5ci7A:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 GLY A  23
GLY A  25
VAL A  30
ALA A  44
VAL A  76
MET A  92
TYR A  94
LEU A 145
 51W  A 401 (-3.3A)
GOL  A 404 ( 3.2A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.60A 3fupB-5ci7A:
26.2		 3fupB-5ci7A:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 11 VAL A  30
ALA A  44
VAL A  76
TYR A  94
CYH A  95
GLY A  98
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.45A 3g0eA-5ci7A:
21.5		 3g0eA-5ci7A:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 11 VAL A  30
ALA A  44
TYR A  94
CYH A  95
GLY A  98
ASP A  99
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-3.8A)
51W  A 401 (-4.5A)
 0.30A 3g0fA-5ci7A:
23.1		 3g0fA-5ci7A:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 10 VAL A  30
ALA A  44
TYR A  94
CYH A  95
GLY A  98
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.28A 3g0fB-5ci7A:
23.4		 3g0fB-5ci7A:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 GLY A  23
VAL A  30
ALA A  44
VAL A  76
MET A  92
TYR A  94
LEU A 145
ALA A 164
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
None
 0.83A 3lxkA-5ci7A:
26.5		 3lxkA-5ci7A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  44
VAL A  76
TYR A  94
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.70A 3oezA-5ci7A:
23.1		 3oezA-5ci7A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  44
GLU A  63
TYR A  94
GLY A  98
LEU A 145
ALA A 164
ASP A 165
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
GOL  A 404 (-3.2A)
 0.81A 3qlgB-5ci7A:
24.8		 3qlgB-5ci7A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  44
VAL A  76
TYR A  94
GLY A  98
LEU A 145
ALA A 164
ASP A 165
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
GOL  A 404 (-3.2A)
 0.72A 3qlgB-5ci7A:
24.8		 3qlgB-5ci7A:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  44
LEU A  67
TYR A  94
LEU A 129
HIS A 136
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
None
None
None
 0.91A 3rgfA-5ci7A:
5.1		 3rgfA-5ci7A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  44
LEU A  90
MET A  92
GLY A  98
ASP A 102
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.79A 3ug2A-5ci7A:
21.7		 3ug2A-5ci7A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 8 VAL A  76
CYH A  95
LEU A 145
ILE A 163
 None
51W  A 401 (-3.9A)
51W  A 401 (-4.5A)
None
 0.53A 3wzeA-5ci7A:
23.6		 3wzeA-5ci7A:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ALA A  44
LYS A  46
LEU A 129
HIS A 136
ARG A 137
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.83A 3zosA-5ci7A:
22.4		 3zosA-5ci7A:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 11 ALA A  44
LYS A  46
VAL A  76
CYH A  95
GLY A  98
LEU A 145
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.55A 4agdA-5ci7A:
22.8		 4agdA-5ci7A:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 6 VAL A  76
CYH A  95
LEU A 145
ILE A 163
 None
51W  A 401 (-3.9A)
51W  A 401 (-4.5A)
None
 0.42A 4asdA-5ci7A:
23.3		 4asdA-5ci7A:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 5 VAL A  30
ILE A  75
TYR A  94
ILE A 163
 51W  A 401 ( 4.3A)
None
51W  A 401 ( 3.4A)
None
 0.37A 4c8bA-5ci7A:
22.4		 4c8bA-5ci7A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  44
ILE A  66
VAL A  76
TYR A  94
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
None
 0.87A 4csvA-5ci7A:
23.9		 4csvA-5ci7A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  44
ASP A  99
ASP A 102
ASP A 138
LYS A 140
ASN A 143
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.8A)
None
None
None
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.52A 4i41A-5ci7A:
27.8		 4i41A-5ci7A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  44
LEU A  78
LEU A  90
GLY A  98
LEU A 145
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.68A 4ifgA-5ci7A:
22.6		 4ifgA-5ci7A:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 10 ILE A  22
ALA A  44
VAL A  76
MET A  92
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.78A 4ks8A-5ci7A:
26.4		 4ks8A-5ci7A:
31.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 ALA A  44
GLU A  63
VAL A  76
MET A  92
TYR A  94
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
None
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.87A 4mxyB-5ci7A:
25.6		 4mxyB-5ci7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  44
GLU A  63
VAL A  76
TYR A  94
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.89A 4mxyB-5ci7A:
25.6		 4mxyB-5ci7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 ALA A  44
GLU A  63
VAL A  76
MET A  92
TYR A  94
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
None
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.87A 4mxzB-5ci7A:
25.6		 4mxzB-5ci7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 VAL A  30
ALA A  44
GLU A  63
VAL A  76
TYR A  94
GLY A  98
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
None
 0.89A 4mxzB-5ci7A:
25.6		 4mxzB-5ci7A:
28.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 11 GLY A  23
VAL A  30
ALA A  44
LYS A  46
ASN A 143
LEU A 145
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.56A 4o0sA-5ci7A:
24.6		 4o0sA-5ci7A:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 8 ILE A  22
VAL A  30
ALA A  44
ASN A 143
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.60A 4ogrA-5ci7A:
27.2		 4ogrA-5ci7A:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 9 ILE A  22
VAL A  30
ALA A  44
CYH A  95
ASN A 143
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.63A 4ogrI-5ci7A:
27.1		 4ogrI-5ci7A:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 9 VAL A  30
ALA A  44
CYH A  95
ASP A  99
ASN A 143
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.8A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
 0.73A 4ogrI-5ci7A:
27.1		 4ogrI-5ci7A:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ILE A  22
GLY A  23
VAL A  30
ALA A  44
MET A  92
TYR A  94
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.60A 4qmzA-5ci7A:
29.7		 4qmzA-5ci7A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 ALA A  44
GLU A  63
LEU A 129
ARG A 137
ALA A 164
 51W  A 401 (-3.4A)
None
None
TPO  A 180 ( 2.9A)
None
 1.11A 4qrcA-5ci7A:
19.0		 4qrcA-5ci7A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 6 VAL A  30
ILE A  75
ARG A 137
ILE A 163
 51W  A 401 ( 4.3A)
None
TPO  A 180 ( 2.9A)
None
 0.72A 4tyjA-5ci7A:
23.7		 4tyjA-5ci7A:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 10 VAL A  30
LEU A  70
ILE A  75
VAL A  76
TYR A  94
ARG A 137
ILE A 163
 51W  A 401 ( 4.3A)
None
None
None
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
None
 0.69A 4u0iA-5ci7A:
23.2		 4u0iA-5ci7A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ALA A  44
LYS A  46
LEU A  67
CYH A  95
GLY A  98
HIS A 136
LEU A 145
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.72A 4u0iA-5ci7A:
23.2		 4u0iA-5ci7A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 11 GLY A  25
VAL A  30
ALA A  44
TYR A  94
GLY A  98
ASN A 143
LEU A 145
ALA A 164
 GOL  A 404 ( 3.2A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
None
 0.57A 4u5jA-5ci7A:
27.1		 4u5jA-5ci7A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 9 VAL A  30
TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 4.3A)
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.47A 4v01A-5ci7A:
17.5		 4v01A-5ci7A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 9 VAL A  30
LYS A  46
TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 4.3A)
GOL  A 404 ( 3.1A)
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.83A 4v01B-5ci7A:
17.7		 4v01B-5ci7A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 8 TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.88A 4v04A-5ci7A:
18.6		 4v04A-5ci7A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ALA A  44
LYS A  46
GLU A  63
LEU A  90
GLY A  98
ASP A 102
LEU A 145
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.81A 4wkqA-5ci7A:
25.9		 4wkqA-5ci7A:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  44
LYS A  46
CYH A  95
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
51W  A 401 (-3.9A)
None
 0.68A 4xv2A-5ci7A:
23.0		 4xv2A-5ci7A:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  44
LYS A  46
CYH A  95
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
51W  A 401 (-3.9A)
None
 0.72A 5cswA-5ci7A:
22.8		 5cswA-5ci7A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  44
LYS A  46
LEU A  67
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
 0.87A 5cswA-5ci7A:
22.8		 5cswA-5ci7A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  44
LYS A  46
CYH A  95
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
51W  A 401 (-3.9A)
None
 0.69A 5cswB-5ci7A:
22.8		 5cswB-5ci7A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  44
LYS A  46
LEU A  67
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
 0.86A 5cswB-5ci7A:
22.8		 5cswB-5ci7A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 ILE A  22
ALA A  44
GLU A  63
TYR A  94
GLY A  98
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.66A 5i9xA-5ci7A:
23.4		 5i9xA-5ci7A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 ILE A  22
ALA A  44
LYS A  46
GLU A  63
TYR A  94
GLY A  98
LEU A 145
 51W  A 401 (-3.9A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
 0.68A 5i9yA-5ci7A:
23.1		 5i9yA-5ci7A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  44
VAL A  76
ASP A  99
ALA A 164
ASP A 165
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.8A)
None
GOL  A 404 (-3.2A)
 0.82A 5l2iA-5ci7A:
8.1		 5l2iA-5ci7A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  44
VAL A  76
ASP A  99
LEU A 145
ALA A 164
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.8A)
51W  A 401 (-4.5A)
None
 0.61A 5l2iA-5ci7A:
8.1		 5l2iA-5ci7A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  44
VAL A  76
ASP A  99
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.8A)
51W  A 401 (-4.5A)
None
 0.69A 5l2tA-5ci7A:
8.1		 5l2tA-5ci7A:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 11 GLY A  23
VAL A  30
ALA A  44
VAL A  76
TYR A  94
LEU A 145
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.41A 5lvnA-5ci7A:
29.1		 5lvnA-5ci7A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 9 ILE A  22
GLY A  23
VAL A  30
ALA A  44
MET A  92
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
 0.61A 5lw1B-5ci7A:
23.0		 5lw1B-5ci7A:
14.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		8 / 12 ILE A  22
GLY A  23
VAL A  30
ALA A  44
LYS A  46
GLU A  63
TYR A  94
GLY A  98
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
 0.59A 5mafA-5ci7A:
29.3		 5mafA-5ci7A:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 5 LEU A  67
CYH A  95
LEU A 145
ASP A 165
 None
51W  A 401 (-3.9A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.56A 5mafA-5ci7A:
29.3		 5mafA-5ci7A:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 12 ALA A  44
VAL A  76
HIS A 136
LEU A 145
ALA A 164
 51W  A 401 (-3.4A)
None
None
51W  A 401 (-4.5A)
None
 0.62A 5mo4A-5ci7A:
19.3		 5mo4A-5ci7A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 10 VAL A  30
ALA A  44
VAL A  76
MET A  92
TYR A  94
LEU A 145
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.50A 5n3hA-5ci7A:
28.6		 5n3hA-5ci7A:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		4 / 8 ILE A  66
LEU A  67
MET A  92
LEU A  90
 None
None
51W  A 401 (-3.9A)
None
 1.05A 5u4sB-5ci7A:
undetectable		 5u4sB-5ci7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 ILE A  22
GLY A  23
ALA A  44
TYR A  94
CYH A  95
GLY A  98
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
 0.74A 5vc3A-5ci7A:
26.2		 5vc3A-5ci7A:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		5 / 9 ALA A  44
VAL A  76
MET A  92
CYH A  95
GLY A  98
 51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
 0.63A 5w5vA-5ci7A:
17.7		 5w5vA-5ci7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens) 		6 / 12 VAL A  30
ALA A  44
LYS A  46
LEU A  90
GLY A  98
ASP A 165
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.7A)
GOL  A 404 (-3.2A)
 1.04A 5yu9C-5ci7A:
21.6		 5yu9C-5ci7A:
14.08