SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ZY'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
3 / 3 GLY A 124
GLU A 147
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
4ZY  A 501 ( 3.6A)
0.67A 2b25B-4uoeA:
9.6
2b25B-4uoeA:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLN A 229
ASP A 196
TYR A 264
PRO A 265
ILE A 261
4ZY  A 501 (-4.2A)
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-3.4A)
None
None
1.43A 3b7pA-4uoeA:
51.1
3b7pA-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-3.4A)
None
None
1.33A 3b7pA-4uoeA:
51.1
3b7pA-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
11 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-2.5A)
4ZY  A 501 (-4.2A)
4ZY  A 501 (-3.4A)
None
4ZY  A 501 ( 4.7A)
0.26A 3b7pA-4uoeA:
51.1
3b7pA-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
None
1.46A 3b7pA-4uoeA:
51.1
3b7pA-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-3.4A)
None
None
1.40A 3b7pB-4uoeA:
49.4
3b7pB-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
11 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-2.5A)
4ZY  A 501 (-4.2A)
4ZY  A 501 (-3.4A)
None
4ZY  A 501 ( 4.7A)
0.31A 3b7pB-4uoeA:
49.4
3b7pB-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLN A 229
ASP A 196
TYR A 264
PRO A 265
ILE A 261
4ZY  A 501 (-4.2A)
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-3.4A)
None
None
1.43A 3b7pC-4uoeA:
49.9
3b7pC-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-3.4A)
None
None
1.34A 3b7pC-4uoeA:
49.9
3b7pC-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
12 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLU A 231
SER A 232
TYR A 264
PRO A 265
ILE A 269
None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-2.5A)
4ZY  A 501 ( 4.7A)
None
4ZY  A 501 (-3.4A)
None
4ZY  A 501 ( 4.7A)
0.23A 3b7pC-4uoeA:
49.9
3b7pC-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
None
1.42A 3b7pC-4uoeA:
49.9
3b7pC-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
6 / 12 GLN A  72
HIS A 103
GLY A 124
ILE A 148
ASP A 178
GLN A 229
MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.5A)
MTA  A 401 (-3.8A)
MTA  A 401 (-3.2A)
4ZY  A 501 (-4.2A)
0.83A 3bwcA-4uoeA:
38.3
3bwcA-4uoeA:
40.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
8 / 12 GLN A  72
TYR A 102
HIS A 103
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
MTA  A 401 (-3.3A)
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-3.5A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.3A)
MTA  A 401 (-3.2A)
0.39A 3bwcA-4uoeA:
38.3
3bwcA-4uoeA:
40.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
6 / 12 LEU A  88
TYR A 102
GLY A 125
ASP A 149
VAL A 152
ASP A 196
None
4ZY  A 501 (-4.3A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
1.20A 3bwcB-4uoeA:
29.1
3bwcB-4uoeA:
40.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
9 / 12 LEU A  88
TYR A 102
HIS A 103
GLY A 124
ASP A 127
ILE A 148
ASP A 149
VAL A 152
ASP A 196
None
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-3.5A)
MTA  A 401 (-4.3A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
0.42A 3bwcB-4uoeA:
29.1
3bwcB-4uoeA:
40.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 11 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
4ZY  A 501 ( 3.6A)
0.77A 3id5B-4uoeA:
10.4
3id5B-4uoeA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 11 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
4ZY  A 501 ( 3.6A)
0.77A 3id5F-4uoeA:
6.6
3id5F-4uoeA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
4ZY  A 501 ( 3.6A)
0.73A 3id6C-4uoeA:
10.0
3id6C-4uoeA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLY A 128
GLY A 129
ASP A 149
ASP A 196
LEU A 207
None
None
None
4ZY  A 501 ( 3.6A)
MTA  A 401 (-4.4A)
0.73A 3m6vA-4uoeA:
10.0
3m6vA-4uoeA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLY A 128
GLY A 129
ASP A 149
ASP A 196
LEU A 207
None
None
None
4ZY  A 501 ( 3.6A)
MTA  A 401 (-4.4A)
0.72A 3m6vB-4uoeA:
10.1
3m6vB-4uoeA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
0.76A 3mb5A-4uoeA:
12.5
3mb5A-4uoeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
4ZY  A 501 ( 3.6A)
0.75A 3nmuA-4uoeA:
undetectable
3nmuF-4uoeA:
9.6
3nmuA-4uoeA:
21.57
3nmuF-4uoeA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
MTA  A 401 (-3.6A)
4ZY  A 501 ( 3.6A)
0.81A 3nvkF-4uoeA:
undetectable
3nvkJ-4uoeA:
11.9
3nvkF-4uoeA:
22.06
3nvkJ-4uoeA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 6 HIS A 103
GLU A 147
ASP A 178
ASP A 196
None
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
1.28A 3vywA-4uoeA:
15.6
3vywA-4uoeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 6 GLY A 126
GLU A 147
ASP A 178
ASP A 196
MTA  A 401 ( 4.5A)
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
0.76A 3vywC-4uoeA:
15.6
3vywC-4uoeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 8 ASP A 196
SER A 197
SER A 198
GLN A  72
4ZY  A 501 ( 3.6A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.3A)
0.80A 4af0A-4uoeA:
undetectable
4af0A-4uoeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 6 HIS A 103
GLU A 147
ASP A 178
ASP A 196
None
MTA  A 401 (-2.7A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
1.41A 4blvA-4uoeA:
11.2
4blvA-4uoeA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
5 / 11 TYR A 137
ASP A 127
HIS A 103
ASP A 196
GLY A 125
None
MTA  A 401 (-4.3A)
None
4ZY  A 501 ( 3.6A)
MTA  A 401 (-3.8A)
1.45A 4qa0B-4uoeA:
5.1
4qa0B-4uoeA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 7 GLY A 124
GLY A 126
ASP A 178
ASP A 196
MTA  A 401 (-3.5A)
MTA  A 401 ( 4.5A)
MTA  A 401 (-3.2A)
4ZY  A 501 ( 3.6A)
0.77A 5ergB-4uoeA:
9.6
5ergB-4uoeA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
4 / 5 HIS A 236
SER A 232
GLN A 229
TYR A 264
None
None
4ZY  A 501 (-4.2A)
4ZY  A 501 (-3.4A)
1.50A 5fuqA-4uoeA:
undetectable
5fuqB-4uoeA:
undetectable
5fuqA-4uoeA:
22.55
5fuqB-4uoeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)
4uoe SPERMIDINE SYNTHASE
(Plasmodium
falciparum)
3 / 3 TYR A 264
HIS A 103
MET A 106
4ZY  A 501 (-3.4A)
None
None
1.14A 6af6A-4uoeA:
undetectable
6af6A-4uoeA:
19.17