SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ZY'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2B25_B_SAMB602_1 (HYPOTHETICAL PROTEIN) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 3 / 3 | GLY A 124GLU A 147ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)4ZY A 501 ( 3.6A) | 0.67A | 2b25B-4uoeA:9.6 | 2b25B-4uoeA:24.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLN A 229ASP A 196TYR A 264PRO A 265ILE A 261 | 4ZY A 501 (-4.2A)4ZY A 501 ( 3.6A)4ZY A 501 (-3.4A)NoneNone | 1.43A | 3b7pA-4uoeA:51.1 | 3b7pA-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | HIS A 103ASP A 196TYR A 264PRO A 265ILE A 261 | None4ZY A 501 ( 3.6A)4ZY A 501 (-3.4A)NoneNone | 1.33A | 3b7pA-4uoeA:51.1 | 3b7pA-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 11 / 12 | TRP A 51GLN A 93TYR A 102HIS A 103ASP A 127ASP A 196ASP A 199GLN A 229TYR A 264PRO A 265ILE A 269 | None4ZY A 501 ( 3.6A)4ZY A 501 (-4.3A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A)4ZY A 501 (-2.5A)4ZY A 501 (-4.2A)4ZY A 501 (-3.4A)None4ZY A 501 ( 4.7A) | 0.26A | 3b7pA-4uoeA:51.1 | 3b7pA-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | TYR A 102HIS A 103ASP A 127ASP A 196ILE A 259 | 4ZY A 501 (-4.3A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A)None | 1.46A | 3b7pA-4uoeA:51.1 | 3b7pA-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_B_SPMB502_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | HIS A 103ASP A 196TYR A 264PRO A 265ILE A 261 | None4ZY A 501 ( 3.6A)4ZY A 501 (-3.4A)NoneNone | 1.40A | 3b7pB-4uoeA:49.4 | 3b7pB-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_B_SPMB502_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 11 / 12 | TRP A 51GLN A 93TYR A 102HIS A 103ASP A 127ASP A 196ASP A 199GLN A 229TYR A 264PRO A 265ILE A 269 | None4ZY A 501 ( 3.6A)4ZY A 501 (-4.3A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A)4ZY A 501 (-2.5A)4ZY A 501 (-4.2A)4ZY A 501 (-3.4A)None4ZY A 501 ( 4.7A) | 0.31A | 3b7pB-4uoeA:49.4 | 3b7pB-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLN A 229ASP A 196TYR A 264PRO A 265ILE A 261 | 4ZY A 501 (-4.2A)4ZY A 501 ( 3.6A)4ZY A 501 (-3.4A)NoneNone | 1.43A | 3b7pC-4uoeA:49.9 | 3b7pC-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | HIS A 103ASP A 196TYR A 264PRO A 265ILE A 261 | None4ZY A 501 ( 3.6A)4ZY A 501 (-3.4A)NoneNone | 1.34A | 3b7pC-4uoeA:49.9 | 3b7pC-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 12 / 12 | TRP A 51GLN A 93TYR A 102HIS A 103ASP A 127ASP A 196ASP A 199GLU A 231SER A 232TYR A 264PRO A 265ILE A 269 | None4ZY A 501 ( 3.6A)4ZY A 501 (-4.3A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A)4ZY A 501 (-2.5A)4ZY A 501 ( 4.7A)None4ZY A 501 (-3.4A)None4ZY A 501 ( 4.7A) | 0.23A | 3b7pC-4uoeA:49.9 | 3b7pC-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | TYR A 102HIS A 103ASP A 127ASP A 196ILE A 259 | 4ZY A 501 (-4.3A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A)None | 1.42A | 3b7pC-4uoeA:49.9 | 3b7pC-4uoeA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BWC_A_SAMA501_0 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 6 / 12 | GLN A 72HIS A 103GLY A 124ILE A 148ASP A 178GLN A 229 | MTA A 401 (-3.3A)NoneMTA A 401 (-3.5A)MTA A 401 (-3.8A)MTA A 401 (-3.2A)4ZY A 501 (-4.2A) | 0.83A | 3bwcA-4uoeA:38.3 | 3bwcA-4uoeA:40.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BWC_A_SAMA501_0 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 8 / 12 | GLN A 72TYR A 102HIS A 103GLY A 124ILE A 148ASP A 149VAL A 152ASP A 178 | MTA A 401 (-3.3A)4ZY A 501 (-4.3A)NoneMTA A 401 (-3.5A)MTA A 401 (-3.8A)NoneMTA A 401 (-4.3A)MTA A 401 (-3.2A) | 0.39A | 3bwcA-4uoeA:38.3 | 3bwcA-4uoeA:40.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 6 / 12 | LEU A 88TYR A 102GLY A 125ASP A 149VAL A 152ASP A 196 | None4ZY A 501 (-4.3A)MTA A 401 (-3.8A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A) | 1.20A | 3bwcB-4uoeA:29.1 | 3bwcB-4uoeA:40.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 9 / 12 | LEU A 88TYR A 102HIS A 103GLY A 124ASP A 127ILE A 148ASP A 149VAL A 152ASP A 196 | None4ZY A 501 (-4.3A)NoneMTA A 401 (-3.5A)MTA A 401 (-4.3A)MTA A 401 (-3.8A)NoneMTA A 401 (-4.3A)4ZY A 501 ( 3.6A) | 0.42A | 3bwcB-4uoeA:29.1 | 3bwcB-4uoeA:40.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ID5_B_SAMB301_0 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 11 | GLY A 124GLU A 147ASP A 178ALA A 179ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)4ZY A 501 ( 3.6A) | 0.77A | 3id5B-4uoeA:10.4 | 3id5B-4uoeA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ID5_F_SAMF301_0 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 11 | GLY A 124GLU A 147ASP A 178ALA A 179ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)4ZY A 501 ( 3.6A) | 0.77A | 3id5F-4uoeA:6.6 | 3id5F-4uoeA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ID6_C_SAMC301_0 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLY A 124GLU A 147ASP A 178ALA A 179ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)4ZY A 501 ( 3.6A) | 0.73A | 3id6C-4uoeA:10.0 | 3id6C-4uoeA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3M6V_A_SAMA465_0 (RRNA METHYLASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLY A 128GLY A 129ASP A 149ASP A 196LEU A 207 | NoneNoneNone4ZY A 501 ( 3.6A)MTA A 401 (-4.4A) | 0.73A | 3m6vA-4uoeA:10.0 | 3m6vA-4uoeA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3M6V_B_SAMB465_0 (RRNA METHYLASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLY A 128GLY A 129ASP A 149ASP A 196LEU A 207 | NoneNoneNone4ZY A 501 ( 3.6A)MTA A 401 (-4.4A) | 0.72A | 3m6vB-4uoeA:10.1 | 3m6vB-4uoeA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MB5_A_SAMA301_1 (SAM-DEPENDENTMETHYLTRANSFERASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 4 | GLY A 124GLU A 147ASP A 178ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)4ZY A 501 ( 3.6A) | 0.76A | 3mb5A-4uoeA:12.5 | 3mb5A-4uoeA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NMU_F_SAMF228_0 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASENOP5/NOP56 RELATEDPROTEIN) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLY A 124GLU A 147ASP A 178ALA A 179ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)4ZY A 501 ( 3.6A) | 0.75A | 3nmuA-4uoeA:undetectable3nmuF-4uoeA:9.6 | 3nmuA-4uoeA:21.573nmuF-4uoeA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NVK_J_SAMJ228_0 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASENOP5/NOP56 RELATEDPROTEIN) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 12 | GLY A 124GLU A 147ASP A 178ALA A 179ASP A 196 | MTA A 401 (-3.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)MTA A 401 (-3.6A)4ZY A 501 ( 3.6A) | 0.81A | 3nvkF-4uoeA:undetectable3nvkJ-4uoeA:11.9 | 3nvkF-4uoeA:22.063nvkJ-4uoeA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VYW_A_SAMA501_1 (MNMC2) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 6 | HIS A 103GLU A 147ASP A 178ASP A 196 | NoneMTA A 401 (-2.7A)MTA A 401 (-3.2A)4ZY A 501 ( 3.6A) | 1.28A | 3vywA-4uoeA:15.6 | 3vywA-4uoeA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VYW_C_SAMC401_1 (MNMC2) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 6 | GLY A 126GLU A 147ASP A 178ASP A 196 | MTA A 401 ( 4.5A)MTA A 401 (-2.7A)MTA A 401 (-3.2A)4ZY A 501 ( 3.6A) | 0.76A | 3vywC-4uoeA:15.6 | 3vywC-4uoeA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AF0_A_MOAA1526_1 (INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 8 | ASP A 196SER A 197SER A 198GLN A 72 | 4ZY A 501 ( 3.6A)NoneMTA A 401 (-3.3A)MTA A 401 (-3.3A) | 0.80A | 4af0A-4uoeA:undetectable | 4af0A-4uoeA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4BLV_A_SAMA1281_1 (RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 6 | HIS A 103GLU A 147ASP A 178ASP A 196 | NoneMTA A 401 (-2.7A)MTA A 401 (-3.2A)4ZY A 501 ( 3.6A) | 1.41A | 4blvA-4uoeA:11.2 | 4blvA-4uoeA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QA0_B_SHHB404_2 (HISTONE DEACETYLASE8) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 5 / 11 | TYR A 137ASP A 127HIS A 103ASP A 196GLY A 125 | NoneMTA A 401 (-4.3A)None4ZY A 501 ( 3.6A)MTA A 401 (-3.8A) | 1.45A | 4qa0B-4uoeA:5.1 | 4qa0B-4uoeA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ERG_B_SAMB401_1 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRM61) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 7 | GLY A 124GLY A 126ASP A 178ASP A 196 | MTA A 401 (-3.5A)MTA A 401 ( 4.5A)MTA A 401 (-3.2A)4ZY A 501 ( 3.6A) | 0.77A | 5ergB-4uoeA:9.6 | 5ergB-4uoeA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5FUQ_A_ACTA1278_0 (NAD(P)HDEHYDROGENASE[QUINONE] 1) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 4 / 5 | HIS A 236SER A 232GLN A 229TYR A 264 | NoneNone4ZY A 501 (-4.2A)4ZY A 501 (-3.4A) | 1.50A | 5fuqA-4uoeA:undetectable5fuqB-4uoeA:undetectable | 5fuqA-4uoeA:22.555fuqB-4uoeA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AF6_A_GLYA507_0 (L-PROLYL-[PEPTIDYL-CARRIER PROTEIN]DEHYDROGENASE) |
4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) | 3 / 3 | TYR A 264HIS A 103MET A 106 | 4ZY A 501 (-3.4A)NoneNone | 1.14A | 6af6A-4uoeA:undetectable | 6af6A-4uoeA:19.17 |