SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ZS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 LEU A 664
LEU A 665
GLY A 616
THR A 611
ILE A 595
 4ZS  A 901 (-3.6A)
None
None
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.3A)
 1.44A 1p93A-5ezrA:
undetectable		 1p93A-5ezrA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 6 ILE A 540
VAL A 548
ILE A 594
ILE A 653
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
None
None
 0.77A 1uwhA-5ezrA:
20.0		 1uwhA-5ezrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 7 ILE A 540
LYS A 563
ILE A 594
ASP A 675
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
 0.87A 1uwjA-5ezrA:
10.3		 1uwjA-5ezrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 7 ILE A 540
LYS A 563
ILE A 594
ILE A 653
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-3.9A)
None
None
 0.87A 1uwjA-5ezrA:
10.3		 1uwjA-5ezrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 ILE A 540
ARG A 542
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
 4ZS  A 901 (-4.2A)
None
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
 0.66A 2y7jA-5ezrA:
27.8		 2y7jA-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
GLU A 618
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
 0.72A 2y7jA-5ezrA:
27.8		 2y7jA-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
ASP A 675
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
None
 0.67A 2y7jB-5ezrA:
27.7		 2y7jB-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
 0.51A 2y7jB-5ezrA:
27.7		 2y7jB-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
 0.49A 2y7jC-5ezrA:
27.8		 2y7jC-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 10 ILE A 540
VAL A 548
ALA A 561
ILE A 595
LEU A 613
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
 0.57A 2y7jD-5ezrA:
27.3		 2y7jD-5ezrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ALA A 561
ILE A 595
THR A 611
LEU A 613
ASP A 675
 4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
None
 0.75A 3hecA-5ezrA:
20.3		 3hecA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ALA A 561
LYS A 563
ILE A 595
THR A 611
LEU A 613
 4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
 0.65A 3hecA-5ezrA:
20.3		 3hecA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
 0.72A 3hegA-5ezrA:
17.7		 3hegA-5ezrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
VAL A 614
LEU A 664
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.8A)
4ZS  A 901 (-3.6A)
 0.60A 3lxnA-5ezrA:
21.8		 3lxnA-5ezrA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
 0.49A 3ohtA-5ezrA:
5.0		 3ohtA-5ezrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
 0.42A 3ohtB-5ezrA:
4.9		 3ohtB-5ezrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 8 VAL A 548
LYS A 563
ILE A 595
ILE A 674
 4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
 0.56A 3warA-5ezrA:
23.5		 3warA-5ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 VAL A 548
ALA A 561
ILE A 595
THR A 611
LEU A 664
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
None
 1.03A 4bkjB-5ezrA:
19.5		 4bkjB-5ezrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		8 / 12 VAL A 548
ALA A 561
ILE A 595
ASP A 657
ASN A 662
LEU A 664
ILE A 674
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
None
None
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
None
 0.78A 4i41A-5ezrA:
25.3		 4i41A-5ezrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		8 / 12 VAL A 548
ALA A 561
ILE A 595
ASP A 657
LYS A 659
ASN A 662
LEU A 664
ILE A 674
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
None
None
None
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
 0.82A 4i41A-5ezrA:
25.3		 4i41A-5ezrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 11 VAL A 548
ALA A 561
LYS A 563
LEU A 664
ILE A 674
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
None
 0.67A 4iaaA-5ezrA:
25.4		 4iaaA-5ezrA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		8 / 12 GLY A 541
VAL A 548
ALA A 561
LEU A 597
GLY A 617
GLU A 618
LEU A 664
ILE A 674
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
None
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
4ZS  A 901 (-3.9A)
 0.68A 4ifgA-5ezrA:
22.7		 4ifgA-5ezrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
LEU A 664
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
None
 0.78A 4r7iA-5ezrA:
18.3		 4r7iA-5ezrA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		10 / 10 ILE A 540
ALA A 561
LYS A 563
THR A 586
ILE A 595
PHE A 609
THR A 611
LEU A 613
VAL A 614
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.4A)
4ZS  A 901 (-4.3A)
None
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.8A)
4ZS  A 901 (-3.6A)
 0.38A 4rz7A-5ezrA:
55.5		 4rz7A-5ezrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		6 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
ASP A 675
PHE A 676
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
None
4ZS  A 901 (-4.9A)
 0.88A 4xv2A-5ezrA:
19.5		 4xv2A-5ezrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 ALA A 561
LYS A 563
THR A 611
ASP A 675
PHE A 676
 4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
None
4ZS  A 901 (-4.9A)
 0.85A 4xv2B-5ezrA:
19.7		 4xv2B-5ezrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
PHE A 676
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.9A)
 0.79A 5cswA-5ezrA:
19.4		 5cswA-5ezrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
PHE A 676
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.9A)
 0.78A 5cswB-5ezrA:
19.5		 5cswB-5ezrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 5 ALA A 634
TYR A 637
GLY A 543
LEU A 664
 None
None
None
4ZS  A 901 (-3.6A)
 1.02A 5eslA-5ezrA:
undetectable		 5eslA-5ezrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 9 ILE A 540
GLY A 541
VAL A 548
ALA A 561
ILE A 595
 4ZS  A 901 (-4.2A)
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
 0.27A 5lw1B-5ezrA:
21.9		 5lw1B-5ezrA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 10 GLY A 541
VAL A 548
ALA A 561
ILE A 595
LEU A 613
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
 0.42A 5lw1E-5ezrA:
21.8		 5lw1E-5ezrA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		7 / 12 VAL A 548
ALA A 561
LYS A 563
THR A 611
LEU A 613
LEU A 664
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
None
 0.57A 5y80A-5ezrA:
23.5		 5y80A-5ezrA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 7 VAL A 548
LYS A 563
ILE A 674
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.9A)
None
 0.82A 5yf9B-5ezrA:
22.1		 5yf9B-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		5 / 9 VAL A 548
LYS A 563
ILE A 595
ILE A 674
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
None
 0.82A 5yf9X-5ezrA:
22.4		 5yf9X-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 7 LYS A 563
ILE A 595
ILE A 674
ASP A 675
 4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
None
 0.60A 5ywmX-5ezrA:
22.3		 5ywmX-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		4 / 7 VAL A 548
LYS A 563
ILE A 595
ILE A 674
 4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
 0.41A 5ywmX-5ezrA:
22.3		 5ywmX-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE
(Plasmodium
vivax) 		3 / 3 LYS A 563
LEU A 664
ASP A 675
 4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.6A)
None
 0.84A 5zv2A-5ezrA:
18.3		 5zv2A-5ezrA:
7.52