SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4YB'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_C_THAC3_1 (LIVER CARBOXYLESTERASE I)	5c5h	2-SUCCINYLBENZOATE-- COA LIGASE (Escherichia coli)	5 / 12	GLY A 270 VAL A 305 LEU A 307 LEU A 293 MET A 340	4YB A 502 (-4.4A) None None None None	1.25A	1mx1C-5c5hA: undetectable	1mx1C-5c5hA: 24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CP4_A_CAMA416_0 (CYTOCHROME P450-CAM)	5c5h	2-SUCCINYLBENZOATE-- COA LIGASE (Escherichia coli)	5 / 10	THR A 334 LEU A 271 VAL A 278 GLY A 270 VAL A 289	None 4YB A 502 (-4.3A) None 4YB A 502 (-4.4A) None	1.36A	2cp4A-5c5hA: undetectable	2cp4A-5c5hA: 24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_A_SAMA500_0 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	5c5h	2-SUCCINYLBENZOATE-- COA LIGASE (Escherichia coli)	5 / 12	ALA A 249 GLY A 247 GLY A 270 THR A 226 VAL A 224	4YB A 502 (-4.1A) 4YB A 502 (-3.6A) 4YB A 502 (-4.4A) None 4YB A 502 ( 4.8A)	0.96A	2okcA-5c5hA: undetectable	2okcA-5c5hA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_A_SAMA300_1 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	5c5h	2-SUCCINYLBENZOATE-- COA LIGASE (Escherichia coli)	3 / 3	SER A 276 HIS A 220 ASP A 174	4YB A 502 (-3.9A) None None	0.82A	2oxtA-5c5hA: 2.3	2oxtA-5c5hA: 20.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX1_C_THAC3_1","LIVER CARBOXYLESTERASE I","5c5h","2-SUCCINYLBENZOATE--COA LIGASE","Escherichia coli",5,"GLY A 270;VAL A 305;LEU A 307;LEU A 293;MET A 340","4YB A 502 (-4.4A);None;None;None;None","1.25A","1mx1C-5c5hA:undetectable",null],["2CP4_A_CAMA416_0","CYTOCHROME P450-CAM","5c5h","2-SUCCINYLBENZOATE--COA LIGASE","Escherichia coli",5,"THR A 334;LEU A 271;VAL A 278;GLY A 270;VAL A 289","None;4YB A 502 (-4.3A);None;4YB A 502 (-4.4A);None","1.36A","2cp4A-5c5hA:undetectable","1mx1C-5c5hA:24.87"],["2OKC_A_SAMA500_0","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","5c5h","2-SUCCINYLBENZOATE--COA LIGASE","Escherichia coli",5,"ALA A 249;GLY A 247;GLY A 270;THR A 226;VAL A 224","4YB A 502 (-4.1A);4YB A 502 (-3.6A);4YB A 502 (-4.4A);None;4YB A 502 ( 4.8A)","0.96A","2okcA-5c5hA:undetectable","2cp4A-5c5hA:24.05"],["2OXT_A_SAMA300_1","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","5c5h","2-SUCCINYLBENZOATE--COA LIGASE","Escherichia coli",3,"SER A 276;HIS A 220;ASP A 174","4YB A 502 (-3.9A);None;None","0.82A","2oxtA-5c5hA:2.3","2okcA-5c5hA:23.55"]]