SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4VP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4s13 FERULIC ACID
DECARBOXYLASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 341
LEU A 333
MET A 228
 None
None
4VP  A 601 ( 3.7A)
 0.62A 2itzA-4s13A:
undetectable		 2itzA-4s13A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4s13 FERULIC ACID
DECARBOXYLASE 1
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 156
SER A 317
GLU A 285
ASP A 324
 None
None
4VP  A 601 (-2.3A)
None
 1.43A 5lsaA-4s13A:
undetectable		 5lsaA-4s13A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4s13 FERULIC ACID
DECARBOXYLASE 1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 356
HIS A  81
ASP A 324
PRO A 319
GLU A 285
 None
None
None
None
4VP  A 601 (-2.3A)
 1.22A 5x6yC-4s13A:
undetectable		 5x6yC-4s13A:
21.45