SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4VN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Streptococcus
pneumoniae) 		4 / 5 HIS A 249
SER A 139
LEU A  54
GLY A 158
 4VN  A 402 (-4.1A)
None
None
None
 0.97A 1a4lB-5bqsA:
undetectable		 1a4lB-5bqsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Streptococcus
pneumoniae) 		5 / 12 GLY A 314
GLY A 313
GLY A 312
SER A 186
ARG A 185
 None
None
4VN  A 402 ( 3.9A)
None
None
 1.10A 1wg8A-5bqsA:
undetectable		 1wg8A-5bqsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Streptococcus
pneumoniae) 		4 / 8 GLU A 140
ASN A 279
HIS A 249
ILE A 287
 None
4VN  A 402 (-2.7A)
4VN  A 402 (-4.1A)
None
 1.32A 3kp6A-5bqsA:
undetectable
3kp6B-5bqsA:
undetectable		 3kp6A-5bqsA:
19.37
3kp6B-5bqsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Streptococcus
pneumoniae) 		4 / 8 ILE A 229
ILE A 222
PHE A 220
GLY A 312
 None
None
None
4VN  A 402 ( 3.9A)
 0.94A 4hdlA-5bqsA:
undetectable		 4hdlA-5bqsA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Streptococcus
pneumoniae) 		5 / 12 ALA A  79
GLY A 310
SER A 309
THR A 319
SER A 281
 None
None
None
None
4VN  A 402 ( 4.9A)
 1.30A 5hfjE-5bqsA:
undetectable		 5hfjE-5bqsA:
20.41