SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4TT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.75A 1iepA-3vidA:
30.6		 1iepA-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.73A 1iepB-3vidA:
30.4		 1iepB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 LYS A 868
VAL A 899
ARG A1027
LEU A1035
 None
None
None
4TT  A2001 (-4.8A)
 0.89A 1iepB-3vidA:
30.4		 1iepB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
 0.68A 1opjA-3vidA:
29.9		 1opjA-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
ILE A 892
VAL A 899
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.77A 1opjA-3vidA:
29.9		 1opjA-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.78A 1opjB-3vidA:
29.9		 1opjB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 899
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.81A 1t46A-3vidA:
36.2		 1t46A-3vidA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 899
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-3.7A)
 0.66A 1t46A-3vidA:
36.2		 1t46A-3vidA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 914
CYH A 919
CYH A1024
CYH A1045
 None
4TT  A2001 (-4.3A)
None
None
 0.54A 1t46A-3vidA:
36.2		 1t46A-3vidA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
None
None
 0.65A 1uwhA-3vidA:
27.6		 1uwhA-3vidA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
None
None
 0.65A 1uwhB-3vidA:
27.4		 1uwhB-3vidA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
 4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
None
 0.62A 1uwhB-3vidA:
27.4		 1uwhB-3vidA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
None
 0.71A 1uwjA-3vidA:
7.7		 1uwjA-3vidA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
None
 0.71A 1uwjB-3vidA:
26.7		 1uwjB-3vidA:
27.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
PHE A 918
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
 0.85A 2gqgA-3vidA:
29.8		 2gqgA-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
ALA A 866
LYS A 868
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.83A 2gqgA-3vidA:
29.8		 2gqgA-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.8A)
 0.64A 2gqgB-3vidA:
29.5		 2gqgB-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
VAL A 899
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.64A 2gqgB-3vidA:
29.5		 2gqgB-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.81A 2hyyA-3vidA:
30.6		 2hyyA-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.77A 2hyyB-3vidA:
30.7		 2hyyB-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.72A 2hyyC-3vidA:
30.8		 2hyyC-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.77A 2hyyD-3vidA:
25.8		 2hyyD-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
None
None
None
None
 0.42A 2ivuA-3vidA:
31.9		 2ivuA-3vidA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
GLU A 850
ALA A 866
LYS A 868
VAL A 916
PHE A 918
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
 0.71A 3c7qA-3vidA:
43.6		 3c7qA-3vidA:
85.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 840
GLY A 841
GLU A 850
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.46A 3c7qA-3vidA:
43.6		 3c7qA-3vidA:
85.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 10 LEU A 840
VAL A 848
LYS A 868
PHE A 918
VAL A 898
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.5A)
None
 0.87A 3cs9A-3vidA:
30.7		 3cs9A-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
LYS A 868
VAL A 899
PHE A 918
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.5A)
None
 0.68A 3cs9A-3vidA:
30.7		 3cs9A-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
LEU A1035
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
 0.77A 3cs9A-3vidA:
30.8		 3cs9A-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
None
None
 0.59A 3cs9B-3vidA:
31.3		 3cs9B-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
VAL A 848
LYS A 868
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.8A)
 0.62A 3cs9B-3vidA:
31.3		 3cs9B-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
None
None
 0.51A 3cs9C-3vidA:
26.3		 3cs9C-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
HIS A1026
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.65A 3cs9D-3vidA:
29.7		 3cs9D-3vidA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 6 LEU A 840
VAL A 848
LYS A 868
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.8A)
None
 0.68A 3cs9D-3vidA:
29.6		 3cs9D-3vidA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
 0.52A 3fupB-3vidA:
28.1		 3fupB-3vidA:
29.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 840
VAL A 848
ALA A 866
VAL A 899
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.28A 3g0eA-3vidA:
35.0		 3g0eA-3vidA:
46.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 840
VAL A 848
VAL A 899
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.64A 3g0eA-3vidA:
35.0		 3g0eA-3vidA:
46.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.30A 3g0fA-3vidA:
35.1		 3g0fA-3vidA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 840
VAL A 848
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.73A 3g0fA-3vidA:
35.1		 3g0fA-3vidA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.63A 3g0fB-3vidA:
34.9		 3g0fB-3vidA:
46.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
LEU A 889
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
 0.84A 3gcsA-3vidA:
3.1		 3gcsA-3vidA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
LEU A 889
HIS A1026
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
 0.53A 3gp0A-3vidA:
21.5		 3gp0A-3vidA:
25.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.8A)
None
 0.73A 3gvuA-3vidA:
30.6		 3gvuA-3vidA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.61A 3ik3A-3vidA:
30.4		 3ik3A-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.62A 3ik3B-3vidA:
30.4		 3ik3B-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
ILE A 892
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
 0.64A 3ik3B-3vidA:
30.4		 3ik3B-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.75A 3k5vA-3vidA:
29.9		 3k5vA-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.73A 3k5vB-3vidA:
29.8		 3k5vB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
 0.77A 3lxkA-3vidA:
27.9		 3lxkA-3vidA:
31.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.78A 3ms9A-3vidA:
30.1		 3ms9A-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.74A 3ms9B-3vidA:
30.2		 3ms9B-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.78A 3mssA-3vidA:
30.2		 3mssA-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.75A 3mssB-3vidA:
30.3		 3mssB-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.78A 3mssC-3vidA:
30.2		 3mssC-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
ILE A 892
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.75A 3mssD-3vidA:
30.2		 3mssD-3vidA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
GLY A 922
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
None
None
 0.76A 3oxzA-3vidA:
30.3		 3oxzA-3vidA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 899
GLY A 922
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
None
None
 0.65A 3oxzA-3vidA:
30.3		 3oxzA-3vidA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
ILE A 892
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.84A 3pyyA-3vidA:
31.1		 3pyyA-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.68A 3pyyA-3vidA:
31.1		 3pyyA-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
 0.77A 3pyyA-3vidA:
31.1		 3pyyA-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 892
PHE A 918
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
None
 0.72A 3pyyA-3vidA:
31.1		 3pyyA-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
 0.70A 3pyyA-3vidA:
31.1		 3pyyA-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
ILE A 892
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.74A 3pyyB-3vidA:
26.2		 3pyyB-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.71A 3pyyB-3vidA:
26.2		 3pyyB-3vidA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.72A 3ue4B-3vidA:
31.2		 3ue4B-3vidA:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.73A 3ue4B-3vidA:
31.2		 3ue4B-3vidA:
34.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
GLY A 841
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
None
 0.79A 3wzdA-3vidA:
39.6		 3wzdA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
GLY A 922
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
None
 0.47A 3wzdA-3vidA:
39.6		 3wzdA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
None
 0.54A 3wzeA-3vidA:
40.0		 3wzeA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
ILE A 892
VAL A 916
PHE A 918
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
None
4TT  A2001 (-4.5A)
 0.47A 3wzeA-3vidA:
40.0		 3wzeA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 8 VAL A 898
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
ASP A1046
 None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-4.8A)
None
None
None
 0.51A 3wzeA-3vidA:
40.0		 3wzeA-3vidA:
85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
LEU A1019
HIS A1026
ARG A1027
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.71A 3zosA-3vidA:
30.0		 3zosA-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
LEU A1019
HIS A1026
ARG A1027
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.72A 3zosB-3vidA:
30.3		 3zosB-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 899
VAL A 916
PHE A 918
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.47A 4ag8A-3vidA:
40.0		 4ag8A-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
VAL A 916
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.58A 4ag8A-3vidA:
40.0		 4ag8A-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.44A 4agcA-3vidA:
30.0		 4agcA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
 0.56A 4agcA-3vidA:
30.0		 4agcA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 11 LEU A 840
ALA A 866
VAL A 899
VAL A 916
PHE A 918
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.37A 4agdA-3vidA:
38.8		 4agdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
None
 0.43A 4asdA-3vidA:
39.8		 4asdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
 0.57A 4asdA-3vidA:
39.8		 4asdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 6 ILE A 892
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
 None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-4.8A)
None
None
 0.37A 4asdA-3vidA:
39.8		 4asdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 848
ALA A 866
GLU A 885
ILE A 888
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.96A 4bkjB-3vidA:
30.2		 4bkjB-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 916
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.61A 4ckiA-3vidA:
32.0		 4ckiA-3vidA:
42.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 840
GLY A 841
GLY A 843
VAL A 848
ALA A 866
VAL A 916
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.8A)
 0.43A 4ckjA-3vidA:
32.6		 4ckjA-3vidA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 GLY A 841
VAL A 848
ALA A 866
LEU A 901
GLY A 922
LEU A1035
 4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.49A 4ifgA-3vidA:
19.4		 4ifgA-3vidA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 6 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
4TT  A2001 (-4.8A)
 0.48A 4o0wA-3vidA:
22.6		 4o0wA-3vidA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
GLY A 846
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.8A)
 0.31A 4otiA-3vidA:
18.9		 4otiA-3vidA:
25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
CYH A1024
ARG A1027
 4TT  A2001 (-3.5A)
None
None
None
None
 1.16A 4qrcA-3vidA:
35.1		 4qrcA-3vidA:
46.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
 0.88A 4qrcA-3vidA:
35.1		 4qrcA-3vidA:
46.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 4TT  A2001 (-3.5A)
None
None
None
None
 0.76A 4qrcA-3vidA:
35.1		 4qrcA-3vidA:
46.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
CYH A 919
CYH A1024
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
4TT  A2001 (-4.8A)
None
 0.71A 4r7iA-3vidA:
35.9		 4r7iA-3vidA:
44.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
 0.70A 4twpA-3vidA:
30.0		 4twpA-3vidA:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
 0.67A 4twpB-3vidA:
30.2		 4twpB-3vidA:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
CYH A1024
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.73A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.70A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 840
VAL A 848
LYS A 868
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
 0.31A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 840
VAL A 848
LYS A 868
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
 0.67A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
GLU A 885
VAL A 899
VAL A 914
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
None
None
 0.61A 4u0iA-3vidA:
36.1		 4u0iA-3vidA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 866
LEU A 889
CYH A 919
GLY A 922
CYH A1024
LEU A1035
CYH A1045
ASP A1046
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
None
None
 0.70A 4u0iA-3vidA:
36.1		 4u0iA-3vidA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 866
LEU A 889
CYH A 919
GLY A 922
HIS A1026
LEU A1035
CYH A1045
ASP A1046
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
None
None
 0.63A 4u0iA-3vidA:
36.1		 4u0iA-3vidA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.81A 4uxqA-3vidA:
29.4		 4uxqA-3vidA:
48.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.66A 4uxqA-3vidA:
29.4		 4uxqA-3vidA:
48.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 848
LYS A 868
ARG A1027
ILE A1044
 4TT  A2001 ( 4.5A)
None
None
None
 0.56A 4uxqA-3vidA:
29.4		 4uxqA-3vidA:
48.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
None
 0.46A 4v01A-3vidA:
34.7		 4v01A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 9 LEU A 840
VAL A 848
LYS A 868
CYH A1024
ARG A1027
LEU A1035
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
None
4TT  A2001 (-4.8A)
None
 0.58A 4v01A-3vidA:
34.7		 4v01A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.77A 4v01B-3vidA:
34.9		 4v01B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.53A 4v01B-3vidA:
34.9		 4v01B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
None
 0.75A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
None
 0.47A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 8 LYS A 868
ARG A1027
LEU A1035
ILE A1044
 None
None
4TT  A2001 (-4.8A)
None
 0.50A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.34A 4v04B-3vidA:
35.3		 4v04B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.84A 4v04B-3vidA:
35.3		 4v04B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.51A 4v04B-3vidA:
35.3		 4v04B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
 0.75A 4wa9B-3vidA:
30.3		 4wa9B-3vidA:
34.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.70A 4xeyA-3vidA:
16.7		 4xeyA-3vidA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
GLY A 841
ALA A 866
PHE A 918
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 (-3.5A)
4TT  A2001 (-4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.89A 5ajqA-3vidA:
21.1		 5ajqA-3vidA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 866
LYS A 868
GLU A 885
LEU A 889
CYH A 919
LEU A1019
HIS A1026
 4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
None
None
 0.67A 5hi2A-3vidA:
27.3		 5hi2A-3vidA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLY A 841
GLY A 843
GLY A 846
VAL A 848
 4TT  A2001 ( 4.8A)
None
None
4TT  A2001 ( 4.5A)
 0.22A 5izjB-3vidA:
21.1		 5izjB-3vidA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLY A 841
GLY A 843
VAL A 848
LYS A 868
 4TT  A2001 ( 4.8A)
None
4TT  A2001 ( 4.5A)
None
 0.44A 5j5xA-3vidA:
20.5		 5j5xA-3vidA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.8A)
 0.39A 5lvnA-3vidA:
22.3		 5lvnA-3vidA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 840
VAL A 848
LYS A 868
GLU A 885
PHE A 918
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
 0.54A 5mo4A-3vidA:
8.5		 5mo4A-3vidA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 866
VAL A 899
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.71A 5mo4A-3vidA:
8.5		 5mo4A-3vidA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 8 ALA A 866
GLU A 885
CYH A 919
LEU A1035
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-4.8A)
 0.53A 5owrA-3vidA:
19.6		 5owrA-3vidA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 866
GLU A 885
VAL A 899
PHE A 918
GLY A 922
LEU A1035
 4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.44A 5te0A-3vidA:
22.0		 5te0A-3vidA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 840
VAL A 848
CYH A 919
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-4.3A)
None
 0.49A 5te0A-3vidA:
22.0		 5te0A-3vidA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 4 VAL A 848
LYS A 868
VAL A 899
ASN A1033
 4TT  A2001 ( 4.5A)
None
None
None
 0.89A 5vc3A-3vidA:
21.8		 5vc3A-3vidA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
 1.02A 5vcvA-3vidA:
21.8		 5vcvA-3vidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
 0.60A 5vcyA-3vidA:
21.4		 5vcyA-3vidA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 840
ALA A 866
VAL A 899
CYH A 919
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
 0.42A 5w5vA-3vidA:
8.0		 5w5vA-3vidA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.74A 5y7zA-3vidA:
16.1		 5y7zA-3vidA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.74A 5y7zA-3vidA:
16.1		 5y7zA-3vidA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.74A 5y7zB-3vidA:
21.6		 5y7zB-3vidA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.55A 5y80A-3vidA:
21.0		 5y80A-3vidA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
 0.29A 5zv2A-3vidA:
29.2		 5zv2A-3vidA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
 0.41A 5zv2B-3vidA:
34.4		 5zv2B-3vidA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.77A 6hd4A-3vidA:
29.9		 6hd4A-3vidA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.76A 6hd4B-3vidA:
29.7		 6hd4B-3vidA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.73A 6hd6A-3vidA:
29.8		 6hd6A-3vidA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
PHE A 918
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-4.8A)
None
 0.79A 6hd6B-3vidA:
29.5		 6hd6B-3vidA:
14.84