SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4TP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IB2_A_IBPA3960_1 (LACTOTRANSFERRIN)	1ps6	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE (Escherichia coli)	4 / 4	GLY A 12 VAL A 97 GLY A 135 THR A 134	None None 4TP A 332 ( 4.0A) None	0.72A	3ib2A-1ps6A: 0.0	3ib2A-1ps6A: 25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZME_A_ADNA1002_1 (MYOSIN HEAVY CHAIN KINASE A)	1ps6	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE (Escherichia coli)	5 / 11	PHE A 250 ALA A 246 GLY A 207 VAL A 160 LEU A 270	None None None None 4TP A 332 (-4.8A)	1.12A	4zmeA-1ps6A: undetectable	4zmeA-1ps6A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZME_A_ADNA1002_1 (MYOSIN HEAVY CHAIN KINASE A)	1ps6	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE (Escherichia coli)	5 / 11	PHE A 250 GLY A 207 VAL A 160 LEU A 273 LEU A 270	None None None None 4TP A 332 (-4.8A)	1.17A	4zmeA-1ps6A: undetectable	4zmeA-1ps6A: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESL_A_1YNA701_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1ps6	4-HYDROXYTHREONINE-4 -PHOSPHATE DEHYDROGENASE (Escherichia coli)	4 / 5	ALA A 26 PRO A 11 GLY A 135 LEU A 116	None None 4TP A 332 ( 4.0A) None	1.02A	5eslA-1ps6A: undetectable	5eslA-1ps6A: 20.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3IB2_A_IBPA3960_1","LACTOTRANSFERRIN","1ps6","4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE","Escherichia coli",4,"GLY A  12;VAL A  97;GLY A 135;THR A 134","None;None;4TP A 332 ( 4.0A);None","0.72A","3ib2A-1ps6A:0.0",null],["4ZME_A_ADNA1002_1","MYOSIN HEAVY CHAIN KINASE A","1ps6","4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE","Escherichia coli",5,"PHE A 250;ALA A 246;GLY A 207;VAL A 160;LEU A 270","None;None;None;None;4TP A 332 (-4.8A)","1.12A","4zmeA-1ps6A:undetectable","3ib2A-1ps6A:25.19"],["4ZME_A_ADNA1002_1","MYOSIN HEAVY CHAIN KINASE A","1ps6","4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE","Escherichia coli",5,"PHE A 250;GLY A 207;VAL A 160;LEU A 273;LEU A 270","None;None;None;None;4TP A 332 (-4.8A)","1.17A","4zmeA-1ps6A:undetectable","4zmeA-1ps6A:21.53"],["5ESL_A_1YNA701_2","LANOSTEROL 14-ALPHA DEMETHYLASE","1ps6","4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE","Escherichia coli",4,"ALA A  26;PRO A  11;GLY A 135;LEU A 116","None;None;4TP A 332 ( 4.0A);None","1.02A","5eslA-1ps6A:undetectable","4zmeA-1ps6A:21.53"]]