SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4TG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)		 4zu4 WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 GLN A 228
LEU A 261
ASP A 198
HIS A 178
ILE A 231
 4TG  A 401 (-3.2A)
None
None
None
None
 1.05A 1i6vC-4zu4A:
undetectable		 1i6vC-4zu4A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zu4 WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		3 / 3 TYR A 291
TYR A 260
SER A 283
 4TG  A 401 (-4.5A)
None
None
 0.85A 5iktB-4zu4A:
undetectable		 5iktB-4zu4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4zu4 WXCM-LIKE PROTEIN
(Shewanella
denitrificans) 		5 / 12 GLN A 228
LEU A 261
ASP A 198
HIS A 178
ILE A 231
 4TG  A 401 (-3.2A)
None
None
None
None
 1.22A 5uh6C-4zu4A:
undetectable		 5uh6C-4zu4A:
9.28