SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4T7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		5 / 12 LEU A  74
ALA A 159
ALA A 161
VAL A  68
HIS A 154
 None
None
None
None
4T7  A 501 (-4.1A)
 1.22A 1kt4A-4zxwA:
undetectable		 1kt4A-4zxwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.88A 1rxcB-4zxwA:
undetectable		 1rxcB-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 7 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.91A 1rxcD-4zxwA:
undetectable		 1rxcD-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.89A 1rxcE-4zxwA:
undetectable		 1rxcE-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 7 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.85A 1rxcF-4zxwA:
undetectable		 1rxcF-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.91A 1rxcI-4zxwA:
undetectable		 1rxcI-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.89A 1rxcK-4zxwA:
undetectable		 1rxcK-4zxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 VAL A 371
VAL A 367
ILE A 308
ARG A 243
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-4.7A)
 1.09A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 6 VAL A 371
VAL A 367
ILE A 308
ARG A 393
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-3.7A)
 1.05A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.78A 4e1vA-4zxwA:
undetectable		 4e1vA-4zxwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.85A 4e1vD-4zxwA:
undetectable		 4e1vD-4zxwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		4 / 8 MET A  26
ILE A 365
VAL A 367
PRO A 289
 None
None
4T7  A 501 (-4.8A)
None
 0.84A 4e1vG-4zxwA:
undetectable		 4e1vG-4zxwA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE
(Streptomyces
globisporus) 		3 / 3 HIS A 154
TRP A 241
SER A 306
 4T7  A 501 (-4.1A)
SUC  A 502 (-4.5A)
None
 0.99A 4lrhD-4zxwA:
undetectable		 4lrhD-4zxwA:
18.70