SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ST'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 GLY A 429
VAL A 436
ALA A 452
VAL A 484
ASN A 551
LEU A 553
ASP A 564
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.72A 1fmoE-2j0jA:
22.4		 1fmoE-2j0jA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.60A 1iepA-2j0jA:
32.4		 1iepA-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 7 LYS A 454
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-4.4A)
 0.66A 1iepB-2j0jA:
32.1		 1iepB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.65A 1opjA-2j0jA:
31.6		 1opjA-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.7A)
 0.78A 1opjB-2j0jA:
31.7		 1opjB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
 0.60A 1opjB-2j0jA:
31.7		 1opjB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
VAL A 484
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 1t46A-2j0jA:
33.6		 1t46A-2j0jA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.59A 1uwhA-2j0jA:
29.2		 1uwhA-2j0jA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.57A 1uwhB-2j0jA:
29.1		 1uwhB-2j0jA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.64A 1uwjA-2j0jA:
11.6		 1uwjA-2j0jA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 7 ILE A 428
LYS A 454
ILE A 483
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.7A)
 0.86A 1uwjA-2j0jA:
11.6		 1uwjA-2j0jA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 ILE A 428
VAL A 436
ALA A 452
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.80A 1uwjB-2j0jA:
11.6		 1uwjB-2j0jA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.64A 2gqgA-2j0jA:
33.1		 2gqgA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.70A 2gqgA-2j0jA:
33.1		 2gqgA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.56A 2gqgB-2j0jA:
32.9		 2gqgB-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.61A 2gqgB-2j0jA:
32.9		 2gqgB-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.62A 2hyyA-2j0jA:
32.4		 2hyyA-2j0jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.55A 2hyyA-2j0jA:
32.4		 2hyyA-2j0jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.67A 2hyyB-2j0jA:
32.6		 2hyyB-2j0jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.70A 2hyyD-2j0jA:
32.6		 2hyyD-2j0jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 2oiqA-2j0jA:
32.8		 2oiqA-2j0jA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.62A 2oiqA-2j0jA:
32.8		 2oiqA-2j0jA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.75A 2pl0A-2j0jA:
30.9		 2pl0A-2j0jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.82A 2pl0A-2j0jA:
30.9		 2pl0A-2j0jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
 0.74A 2pl0A-2j0jA:
30.9		 2pl0A-2j0jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 9 VAL A 436
ALA A 452
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.68A 2xp2A-2j0jA:
32.9		 2xp2A-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 ILE A 428
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.85A 2y6oA-2j0jA:
34.4		 2y6oA-2j0jA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
GLU A 506
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-3.5A)
4ST  A1687 (-4.4A)
 0.87A 2y7jA-2j0jA:
24.3		 2y7jA-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 10 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.60A 2y7jB-2j0jA:
24.6		 2y7jB-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 10 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.61A 2y7jC-2j0jA:
24.3		 2y7jC-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 10 ILE A 428
VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.62A 2y7jD-2j0jA:
24.4		 2y7jD-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 8 ALA A 452
MET A 499
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.72A 2yfxA-2j0jA:
32.3		 2yfxA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 8 LEU A 501
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 1.42A 2yfxA-2j0jA:
32.3		 2yfxA-2j0jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.64A 2zvaA-2j0jA:
32.6		 2zvaA-2j0jA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 10 ARG A 426
ALA A 452
VAL A 484
LEU A 501
GLY A 505
LEU A 553
 None
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.84A 3aoxA-2j0jA:
32.0		 3aoxA-2j0jA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 GLY A 429
ALA A 452
LYS A 454
VAL A 484
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 (-3.1A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.80A 3c7qA-2j0jA:
32.6		 3c7qA-2j0jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
GLU A 471
MET A 475
GLY A 505
PHE A 542
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
None
4ST  A1687 (-4.4A)
 0.69A 3cs9A-2j0jA:
32.7		 3cs9A-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
GLU A 471
MET A 475
GLY A 505
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
 0.66A 3cs9B-2j0jA:
32.8		 3cs9B-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 GLU A 471
MET A 475
GLY A 505
HIS A 544
ASP A 564
 4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
4ST  A1687 (-4.7A)
 0.83A 3cs9B-2j0jA:
32.8		 3cs9B-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 9 VAL A 436
LYS A 454
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-4.4A)
 0.49A 3cs9B-2j0jA:
32.8		 3cs9B-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
GLU A 471
MET A 475
PHE A 542
HIS A 544
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.83A 3cs9C-2j0jA:
31.8		 3cs9C-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
GLU A 471
MET A 475
GLY A 505
PHE A 542
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
None
None
 0.61A 3cs9D-2j0jA:
32.1		 3cs9D-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 GLY A 429
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 553
 4ST  A1687 (-3.1A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.69A 3eygA-2j0jA:
30.6		 3eygA-2j0jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 GLY A 429
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 553
 4ST  A1687 (-3.1A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.82A 3fupA-2j0jA:
31.2		 3fupA-2j0jA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 GLY A 429
VAL A 436
ALA A 452
LYS A 454
VAL A 484
MET A 499
LEU A 553
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.53A 3fupB-2j0jA:
31.7		 3fupB-2j0jA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 11 VAL A 436
ALA A 452
VAL A 484
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.49A 3g0eA-2j0jA:
31.2		 3g0eA-2j0jA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.59A 3g5dA-2j0jA:
32.6		 3g5dA-2j0jA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.62A 3gvuA-2j0jA:
32.2		 3gvuA-2j0jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.54A 3ik3A-2j0jA:
32.7		 3ik3A-2j0jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.58A 3ik3B-2j0jA:
32.5		 3ik3B-2j0jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.72A 3k54A-2j0jA:
32.1		 3k54A-2j0jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.72A 3k54A-2j0jA:
32.1		 3k54A-2j0jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.69A 3k5vA-2j0jA:
31.8		 3k5vA-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.69A 3k5vB-2j0jA:
31.7		 3k5vB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.68A 3ms9A-2j0jA:
32.0		 3ms9A-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.65A 3mssA-2j0jA:
32.1		 3mssA-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.70A 3mssB-2j0jA:
32.2		 3mssB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 7 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.56A 3mssB-2j0jA:
32.2		 3mssB-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 LYS A 454
VAL A 484
ILE A 497
ARG A 545
 4ST  A1687 (-3.4A)
None
None
None
 0.67A 3mssC-2j0jA:
32.1		 3mssC-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 VAL A 436
LYS A 454
VAL A 484
ILE A 497
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.40A 3mssD-2j0jA:
32.2		 3mssD-2j0jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.66A 3oezA-2j0jA:
32.6		 3oezA-2j0jA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ILE A 428
VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 566
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
 1.04A 3og7A-2j0jA:
28.7		 3og7A-2j0jA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ILE A 428
VAL A 436
ALA A 452
LYS A 454
CYH A 502
PHE A 565
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
 1.01A 3og7A-2j0jA:
28.7		 3og7A-2j0jA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
HIS A 544
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
None
4ST  A1687 (-4.7A)
 0.84A 3oxzA-2j0jA:
32.7		 3oxzA-2j0jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.63A 3pyyB-2j0jA:
32.6		 3pyyB-2j0jA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.80A 3qlgA-2j0jA:
33.4		 3qlgA-2j0jA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 GLY A 505
VAL A 513
GLY A 563
ALA A 549
ALA A 548
 4ST  A1687 (-3.2A)
None
None
None
None
 1.10A 3sueC-2j0jA:
undetectable		 3sueC-2j0jA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.62A 3sxrA-2j0jA:
31.2		 3sxrA-2j0jA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.78A 3ue4B-2j0jA:
33.8		 3ue4B-2j0jA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.66A 3ue4B-2j0jA:
33.8		 3ue4B-2j0jA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 501
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.89A 3ug2A-2j0jA:
31.8		 3ug2A-2j0jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ILE A 428
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
VAL A 484
 4ST  A1687 (-4.2A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
 0.81A 3v5wA-2j0jA:
8.9		 3v5wA-2j0jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ILE A 428
GLY A 431
GLY A 434
VAL A 436
ALA A 452
VAL A 484
LEU A 553
 4ST  A1687 (-4.2A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.4A)
 1.07A 3v5wA-2j0jA:
8.9		 3v5wA-2j0jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 VAL A 436
ALA A 452
GLU A 471
CYH A 502
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
 0.49A 3wzdA-2j0jA:
32.6		 3wzdA-2j0jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 5 LYS A 454
VAL A 484
LEU A 553
ASP A 564
 4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.91A 3wzdA-2j0jA:
32.6		 3wzdA-2j0jA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
LEU A 501
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.45A 3zbfA-2j0jA:
33.2		 3zbfA-2j0jA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
VAL A 484
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.57A 4ag8A-2j0jA:
33.2		 4ag8A-2j0jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 11 ALA A 452
VAL A 484
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.53A 4agdA-2j0jA:
32.5		 4agdA-2j0jA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
ILE A 497
HIS A 544
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.77A 4c8bA-2j0jA:
27.3		 4c8bA-2j0jA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 10 ILE A 428
ALA A 452
VAL A 484
MET A 499
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
None
4ST  A1687 ( 3.9A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.58A 4ks8A-2j0jA:
24.5		 4ks8A-2j0jA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 7 VAL A 436
ALA A 452
MET A 499
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.64A 4l9iA-2j0jA:
9.1		 4l9iA-2j0jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 8 GLY A 431
VAL A 436
ALA A 452
LYS A 454
MET A 499
LEU A 553
 None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.90A 4l9iB-2j0jA:
20.9		 4l9iB-2j0jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.54A 4mkcA-2j0jA:
33.1		 4mkcA-2j0jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
LEU A 501
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.59A 4mkcA-2j0jA:
33.1		 4mkcA-2j0jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.62A 4mxoA-2j0jA:
32.8		 4mxoA-2j0jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.88A 4mxxA-2j0jA:
32.4		 4mxxA-2j0jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.75A 4mxxA-2j0jA:
32.4		 4mxxA-2j0jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
VAL A 484
ILE A 497
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.93A 4mxyA-2j0jA:
32.4		 4mxyA-2j0jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
VAL A 484
ILE A 497
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.93A 4mxzA-2j0jA:
32.4		 4mxzA-2j0jA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 7 ALA A 452
CYH A 502
ASN A 551
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.69A 4ogrE-2j0jA:
22.8		 4ogrE-2j0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 7 GLY A 429
ALA A 452
CYH A 502
LEU A 553
 4ST  A1687 (-3.1A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
 0.32A 4ogrE-2j0jA:
22.8		 4ogrE-2j0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 9 ILE A 428
VAL A 436
ALA A 452
CYH A 502
ASN A 551
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.4A)
 0.61A 4ogrI-2j0jA:
23.2		 4ogrI-2j0jA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 GLY A 429
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
VAL A 484
LEU A 553
 4ST  A1687 (-3.1A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
 0.67A 4otiA-2j0jA:
20.2		 4otiA-2j0jA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ILE A 428
ALA A 452
LYS A 454
GLU A 471
ILE A 497
LEU A 553
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.83A 4qmnA-2j0jA:
25.8		 4qmnA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 11 ILE A 428
ALA A 452
GLU A 471
ILE A 497
LEU A 553
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.83A 4qmsA-2j0jA:
25.8		 4qmsA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 11 ILE A 428
ALA A 452
LYS A 454
ILE A 497
LEU A 553
ASP A 564
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 4qmsA-2j0jA:
25.8		 4qmsA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
GLY A 505
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-3.2A)
 0.96A 4qmzA-2j0jA:
25.9		 4qmzA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.69A 4qmzA-2j0jA:
25.9		 4qmzA-2j0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 8 VAL A 436
LYS A 454
HIS A 544
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-4.4A)
 0.52A 4qrcA-2j0jA:
33.1		 4qrcA-2j0jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		9 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
CYH A 502
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.79A 4r7iA-2j0jA:
32.2		 4r7iA-2j0jA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 10 ILE A 428
ALA A 452
LYS A 454
LEU A 501
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.4A)
 0.61A 4rz7A-2j0jA:
9.1		 4rz7A-2j0jA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 VAL A 436
ALA A 452
LYS A 454
CYH A 502
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
 0.84A 4rzvB-2j0jA:
27.9		 4rzvB-2j0jA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.53A 4tyjA-2j0jA:
33.1		 4tyjA-2j0jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 VAL A 436
LYS A 454
ILE A 483
ARG A 545
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.72A 4tyjA-2j0jA:
33.1		 4tyjA-2j0jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
CYH A 502
GLY A 505
HIS A 544
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 4u0iA-2j0jA:
33.1		 4u0iA-2j0jA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
GLU A 471
MET A 475
LEU A 537
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
 0.68A 4v01A-2j0jA:
32.2		 4v01A-2j0jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 ALA A 452
GLU A 471
MET A 475
LEU A 537
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
 0.58A 4v01B-2j0jA:
32.6		 4v01B-2j0jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 GLU A 471
MET A 475
LEU A 537
HIS A 544
ASP A 564
 4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.83A 4v01B-2j0jA:
32.6		 4v01B-2j0jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 6 ARG A 426
ALA A 452
MET A 499
LEU A 553
 None
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.92A 4wboC-2j0jA:
14.4		 4wboC-2j0jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.66A 4xliB-2j0jA:
33.6		 4xliB-2j0jA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.7A)
 0.93A 4xv2A-2j0jA:
28.4		 4xv2A-2j0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
None
 0.74A 4xv2A-2j0jA:
28.4		 4xv2A-2j0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
LYS A 454
CYH A 502
GLY A 563
ASP A 564
PHE A 565
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
4ST  A1687 (-4.7A)
None
 1.01A 4xv2B-2j0jA:
28.8		 4xv2B-2j0jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 8 GLY A 429
VAL A 436
ALA A 452
LEU A 501
GLY A 505
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
 0.71A 4zauA-2j0jA:
32.5		 4zauA-2j0jA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 9 VAL A 436
ALA A 452
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.69A 5aaaA-2j0jA:
33.1		 5aaaA-2j0jA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 10 VAL A 436
ALA A 452
LYS A 454
GLY A 505
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.77A 5aabA-2j0jA:
32.8		 5aabA-2j0jA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 10 ALA A 452
CYH A 502
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.46A 5ajqB-2j0jA:
23.3		 5ajqB-2j0jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
None
 0.80A 5cswA-2j0jA:
28.5		 5cswA-2j0jA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 563
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
None
 0.82A 5cswB-2j0jA:
28.5		 5cswB-2j0jA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.64A 5h2uA-2j0jA:
30.0		 5h2uA-2j0jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
ILE A 497
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.81A 5h2uB-2j0jA:
30.2		 5h2uB-2j0jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ARG A 426
ALA A 452
ILE A 497
GLY A 505
LEU A 553
GLY A 563
 None
4ST  A1687 (-3.3A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.87A 5h2uC-2j0jA:
30.0		 5h2uC-2j0jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
ILE A 497
LEU A 501
GLY A 505
LEU A 553
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.3A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
None
 0.82A 5h2uD-2j0jA:
30.1		 5h2uD-2j0jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
CYH A 502
LEU A 537
HIS A 544
GLY A 563
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
None
None
None
 0.50A 5hi2A-2j0jA:
28.4		 5hi2A-2j0jA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 VAL A 436
ALA A 452
LYS A 454
ILE A 497
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
 0.62A 5hieA-2j0jA:
27.7		 5hieA-2j0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 VAL A 436
ALA A 452
LYS A 454
ILE A 497
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
 0.62A 5hieB-2j0jA:
27.7		 5hieB-2j0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 12 VAL A 436
ALA A 452
LYS A 454
ILE A 497
GLY A 563
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
None
 0.63A 5hieD-2j0jA:
27.0		 5hieD-2j0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 8 ILE A 428
GLY A 429
CYH A 502
PHE A 565
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 (-4.1A)
None
 0.94A 5hieD-2j0jA:
27.0		 5hieD-2j0jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ILE A 428
ALA A 452
LYS A 454
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.68A 5i9xA-2j0jA:
33.5		 5i9xA-2j0jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 9 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
 0.44A 5lw1B-2j0jA:
20.5		 5lw1B-2j0jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 10 GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 501
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.3A)
 0.45A 5lw1E-2j0jA:
20.2		 5lw1E-2j0jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 9 GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 501
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.3A)
 0.43A 5lw1H-2j0jA:
20.5		 5lw1H-2j0jA:
8.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 10 VAL A 436
LYS A 454
GLU A 471
ILE A 497
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
 0.30A 5mo4A-2j0jA:
27.0		 5mo4A-2j0jA:
30.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
MET A 475
VAL A 484
PHE A 542
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
None
None
None
None
4ST  A1687 (-4.4A)
 0.75A 5mo4A-2j0jA:
27.0		 5mo4A-2j0jA:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 8 ALA A 452
GLU A 471
CYH A 502
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.83A 5owrA-2j0jA:
21.9		 5owrA-2j0jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 8 GLU A 471
CYH A 502
LEU A 553
ASP A 564
VAL A 513
 4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
None
 1.13A 5owrA-2j0jA:
21.9		 5owrA-2j0jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 ALA A 452
GLU A 471
MET A 475
VAL A 484
GLY A 505
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.54A 5te0A-2j0jA:
23.9		 5te0A-2j0jA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 4 VAL A 436
LYS A 454
VAL A 484
ASN A 551
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.95A 5vc3A-2j0jA:
23.2		 5vc3A-2j0jA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
CYH A 502
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
 0.96A 5vcyA-2j0jA:
23.4		 5vcyA-2j0jA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		4 / 4 VAL A 484
LEU A 501
ASN A 551
ASP A 564
 None
4ST  A1687 (-4.3A)
None
4ST  A1687 (-4.7A)
 1.08A 5vcyA-2j0jA:
23.4		 5vcyA-2j0jA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		5 / 9 ALA A 452
VAL A 484
MET A 499
CYH A 502
GLY A 505
 4ST  A1687 (-3.3A)
None
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
 0.53A 5w5vA-2j0jA:
16.1		 5w5vA-2j0jA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 ARG A 426
VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
LEU A 553
 None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
 0.81A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 ARG A 426
VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
LEU A 553
 None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
 0.81A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.63A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.63A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.71A 5y7zB-2j0jA:
23.4		 5y7zB-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		9 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.60A 5y80A-2j0jA:
23.2		 5y80A-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		3 / 3 LYS A 454
LEU A 553
ASP A 564
 4ST  A1687 (-3.4A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.85A 5zv2A-2j0jA:
32.7		 5zv2A-2j0jA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		6 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
 0.50A 5zv2B-2j0jA:
32.6		 5zv2B-2j0jA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.61A 6bsdA-2j0jA:
30.4		 6bsdA-2j0jA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ILE A 428
VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
 0.74A 6fnmA-2j0jA:
34.5		 6fnmA-2j0jA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.83A 6hd4A-2j0jA:
31.7		 6hd4A-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.70A 6hd4A-2j0jA:
31.7		 6hd4A-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.71A 6hd4B-2j0jA:
31.6		 6hd4B-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.82A 6hd6A-2j0jA:
31.8		 6hd6A-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		8 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.69A 6hd6A-2j0jA:
31.8		 6hd6A-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2j0j FOCAL ADHESION
KINASE 1
(Gallus
gallus) 		7 / 12 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.71A 6hd6B-2j0jA:
31.7		 6hd6B-2j0jA:
7.69