SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4RS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4zrv MINCLE CRD
(Bos
taurus) 		5 / 10 ALA A 179
GLY A 139
GLU A 135
GLU A 176
PRO A 195
 None
None
4RS  A 301 (-3.1A)
4RS  A 301 (-2.5A)
None
 1.36A 1cmcA-4zrvA:
undetectable
1cmcB-4zrvA:
undetectable		 1cmcA-4zrvA:
20.15
1cmcB-4zrvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4zrv MINCLE CRD
(Bos
taurus) 		5 / 11 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 4RS  A 301 (-3.1A)
4RS  A 301 (-2.5A)
None
None
None
 1.36A 1mjqA-4zrvA:
undetectable
1mjqB-4zrvA:
undetectable		 1mjqA-4zrvA:
19.40
1mjqB-4zrvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4zrv MINCLE CRD
(Bos
taurus) 		5 / 10 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 4RS  A 301 (-3.1A)
4RS  A 301 (-2.5A)
None
None
None
 1.32A 1mjqC-4zrvA:
undetectable
1mjqD-4zrvA:
undetectable		 1mjqC-4zrvA:
19.40
1mjqD-4zrvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4zrv MINCLE CRD
(Bos
taurus) 		5 / 11 GLU A 135
GLU A 176
PRO A 195
ALA A 179
GLY A 139
 4RS  A 301 (-3.1A)
4RS  A 301 (-2.5A)
None
None
None
 1.33A 1mjqI-4zrvA:
undetectable
1mjqJ-4zrvA:
undetectable		 1mjqI-4zrvA:
19.40
1mjqJ-4zrvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 4zrv MINCLE CRD
(Bos
taurus) 		4 / 8 ASP A 165
SER A 184
ARG A 182
PRO A 187
 None
None
4RS  A 301 (-3.3A)
None
 1.07A 4uhxA-4zrvA:
undetectable		 4uhxA-4zrvA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4zrv MINCLE CRD
(Bos
taurus) 		4 / 8 ASP A 165
SER A 184
ARG A 182
PRO A 187
 None
None
4RS  A 301 (-3.3A)
None
 1.07A 4uhxA-4zrvA:
undetectable		 4uhxA-4zrvA:
6.91