SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4QZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 ALA A  82
GLU A 102
LEU A 106
ILE A 115
ASP A 200
 None
4QZ  A 401 (-4.3A)
4QZ  A 401 ( 4.7A)
None
None
 1.01A 3gcsA-4zslA:
34.7		 3gcsA-4zslA:
44.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 12 VAL A  69
ALA A  82
GLU A 102
LEU A 106
ILE A 115
 None
None
4QZ  A 401 (-4.3A)
4QZ  A 401 ( 4.7A)
None
 0.88A 3gcsA-4zslA:
34.7		 3gcsA-4zslA:
44.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		6 / 12 VAL A  69
ALA A  82
GLU A 102
LEU A 106
ILE A 115
ASP A 200
 None
None
4QZ  A 401 (-4.3A)
4QZ  A 401 ( 4.7A)
None
None
 1.24A 3hegA-4zslA:
35.7		 3hegA-4zslA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		4 / 6 PHE A  90
ILE A  86
PRO A  87
PHE A 130
 None
4QZ  A 401 (-4.4A)
None
None
 1.09A 4fgkA-4zslA:
undetectable		 4fgkA-4zslA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens) 		5 / 7 GLY A  67
ASP A 143
ASN A 187
LEU A 189
ASP A 200
 4QZ  A 401 ( 4.1A)
None
None
None
None
 1.11A 4ogrE-4zslA:
29.7		 4ogrE-4zslA:
33.53