SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4PZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		7 / 12 ASN A 206
LEU A 210
VAL A 239
ASP A 295
ALA A 299
THR A 303
LEU A 368
 None
None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.90A 1r9oA-3e4eA:
49.2		 1r9oA-3e4eA:
59.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 11 ARG A 100
GLY A 101
ILE A 115
ALA A 299
THR A 303
 HEM  A 500 (-2.4A)
None
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 0.82A 2nnhA-3e4eA:
51.4		 2nnhA-3e4eA:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 10 ILE A 115
ALA A 299
THR A 303
VAL A 364
PRO A 369
 HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
None
 0.69A 2nnjA-3e4eA:
52.3		 2nnjA-3e4eA:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 10 ILE A 115
LEU A 210
ALA A 299
THR A 303
PRO A 369
 HEM  A 500 (-4.0A)
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
None
 1.01A 2nnjA-3e4eA:
52.3		 2nnjA-3e4eA:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		6 / 12 PHE A 116
ASP A 295
ALA A 299
THR A 303
VAL A 364
CYH A 437
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
HEM  A 500 ( 1.6A)
 1.10A 3rukA-3e4eA:
43.4		 3rukA-3e4eA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 12 ARG A 100
ILE A 115
ALA A 299
THR A 303
VAL A 364
 HEM  A 500 (-2.4A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
 0.72A 3s79A-3e4eA:
37.3		 3s79A-3e4eA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 9 ARG A 100
ILE A 115
ALA A 299
THR A 303
VAL A 364
 HEM  A 500 (-2.4A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
 0.62A 3s7sA-3e4eA:
37.0		 3s7sA-3e4eA:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 10 PHE A 106
PHE A 116
ALA A 299
THR A 303
PHE A 478
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
None
 1.28A 3t3qA-3e4eA:
56.7		 3t3qA-3e4eA:
50.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 9 PHE A 116
PHE A 207
PHE A 298
ALA A 299
THR A 303
 None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 1.06A 3t3sA-3e4eA:
56.1		 3t3sA-3e4eA:
51.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 8 PHE A 106
PHE A 116
PHE A 298
ALA A 299
THR A 303
 None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 1.28A 3t3sD-3e4eA:
55.6		 3t3sD-3e4eA:
51.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		6 / 6 PHE A 116
LEU A 210
PHE A 298
ALA A 299
THR A 303
LEU A 368
 None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.25A 3t3zA-3e4eA:
63.9		 3t3zA-3e4eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		6 / 6 PHE A 116
LEU A 210
PHE A 298
ALA A 299
THR A 303
LEU A 368
 None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.24A 3t3zB-3e4eA:
63.8		 3t3zB-3e4eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		4 / 5 PHE A 106
PHE A 298
ALA A 299
THR A 303
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 0.98A 3t3zC-3e4eA:
63.5		 3t3zC-3e4eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 5 PHE A 116
PHE A 298
ALA A 299
THR A 303
LEU A 368
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.28A 3t3zC-3e4eA:
63.5		 3t3zC-3e4eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		6 / 6 PHE A 116
LEU A 210
PHE A 298
ALA A 299
THR A 303
LEU A 368
 None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.28A 3t3zD-3e4eA:
63.6		 3t3zD-3e4eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		4 / 7 PHE A 106
PHE A 116
ALA A 299
THR A 303
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 0.92A 4ejgA-3e4eA:
52.3		 4ejgA-3e4eA:
51.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		4 / 6 PHE A 106
PHE A 116
ALA A 299
THR A 303
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 0.90A 4ejgD-3e4eA:
56.2		 4ejgD-3e4eA:
51.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 10 ARG A 100
ILE A 115
ALA A 299
THR A 303
VAL A 364
 HEM  A 500 (-2.4A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
 0.67A 4kq8A-3e4eA:
37.1		 4kq8A-3e4eA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3e4e CYTOCHROME P450 2E1
(Homo
sapiens) 		5 / 12 ARG A 100
ILE A 115
ALA A 299
THR A 303
VAL A 364
 HEM  A 500 (-2.4A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
 0.72A 5jkvA-3e4eA:
37.2		 5jkvA-3e4eA:
26.56