SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4PL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3rwb PYRIDOXAL
4-DEHYDROGENASE
(Mesorhizobium
loti) 		5 / 12 TYR A 154
ILE A 187
GLY A 185
VAL A 246
GLY A 214
 NAD  A 251 ( 4.5A)
NAD  A 251 (-4.4A)
4PL  A 252 (-4.2A)
GOL  A 249 ( 4.7A)
None
 1.01A 3bwcA-3rwbA:
5.0		 3bwcA-3rwbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3rwb PYRIDOXAL
4-DEHYDROGENASE
(Mesorhizobium
loti) 		3 / 3 ASN A 198
HIS A 197
VAL A  92
 None
4PL  A 252 (-3.6A)
NAD  A 251 (-4.8A)
 0.82A 3elzB-3rwbA:
undetectable		 3elzB-3rwbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3rwb PYRIDOXAL
4-DEHYDROGENASE
(Mesorhizobium
loti) 		4 / 5 SER A 141
ILE A  19
TYR A 154
GLY A 185
 4PL  A 252 (-2.7A)
NAD  A 251 (-3.9A)
NAD  A 251 ( 4.5A)
4PL  A 252 (-4.2A)
 0.93A 3uboB-3rwbA:
7.0		 3uboB-3rwbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3rwb PYRIDOXAL
4-DEHYDROGENASE
(Mesorhizobium
loti) 		5 / 9 ALA A 157
TYR A 154
GLY A 147
SER A 141
GLY A 159
 None
NAD  A 251 ( 4.5A)
None
4PL  A 252 (-2.7A)
None
 1.13A 4mmfB-3rwbA:
undetectable		 4mmfB-3rwbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3rwb PYRIDOXAL
4-DEHYDROGENASE
(Mesorhizobium
loti) 		5 / 10 HIS A 197
ALA A  89
GLY A 115
THR A 114
ILE A  62
 4PL  A 252 (-3.6A)
NAD  A 251 (-3.5A)
None
None
NAD  A 251 (-3.9A)
 1.35A 5vyhA-3rwbA:
undetectable		 5vyhA-3rwbA:
19.17