SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4PG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		8 / 8 HIS U  57
ASP U 189
SER U 190
GLN U 192
SER U 195
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.53A 1aq7A-2r2wU:
34.4		 1aq7A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 9 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.40A 1bcuH-2r2wU:
35.7		 1bcuH-2r2wU:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 HIS U  57
ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.42A 1etrH-2r2wU:
35.1		 1etrH-2r2wU:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 HIS U  57
SER U 195
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-3.5A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.51A 1etrH-2r2wU:
35.1		 1etrH-2r2wU:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 8 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.22A 1f5lA-2r2wU:
47.0		 1f5lA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 6 ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.64A 1tnlA-2r2wU:
15.6		 1tnlA-2r2wU:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 6 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.42A 2otvA-2r2wU:
15.5		 2otvA-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 12 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
TYR U 228
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
None
 0.35A 2p16A-2r2wU:
33.5		 2p16A-2r2wU:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 8 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.31A 2vinA-2r2wU:
46.7		 2vinA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 8 SER U 190
SER U 195
VAL U 213
GLY U 216
 4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
 0.77A 2vinA-2r2wU:
46.7		 2vinA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		7 / 12 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 219
GLY U 226
TYR U 228
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
None
4PG  U 300 (-3.2A)
None
 0.39A 2w26A-2r2wU:
33.5		 2w26A-2r2wU:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		7 / 11 HIS U  57
ASP U 189
SER U 190
GLN U 192
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.48A 3gy3A-2r2wU:
14.9		 3gy3A-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		7 / 11 HIS U  57
SER U 190
GLN U 192
SER U 195
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.65A 3gy3A-2r2wU:
14.9		 3gy3A-2r2wU:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 LEU U 106
GLY U  43
GLY U  44
SER U 190
ASP U 102
 None
None
None
4PG  U 300 (-2.7A)
None
 1.02A 3i5uB-2r2wU:
undetectable		 3i5uB-2r2wU:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		6 / 6 SER U 190
SER U 195
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.56A 3rxfA-2r2wU:
14.1		 3rxfA-2r2wU:
39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 5 ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.2A)
 0.59A 3rxhA-2r2wU:
15.4		 3rxhA-2r2wU:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 5 HIS U  99
SER U 214
SER U 195
VAL U 213
 4PG  U 300 (-4.1A)
None
4PG  U 300 (-3.5A)
None
 1.42A 4a99D-2r2wU:
undetectable		 4a99D-2r2wU:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 5 HIS U  57
GLN U 192
GLY U 193
SER U 195
 4PG  U 300 (-3.9A)
4PG  U 300 (-3.7A)
4PG  U 300 (-4.1A)
4PG  U 300 (-3.5A)
 1.04A 4fu8A-2r2wU:
45.9		 4fu8A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		4 / 5 HIS U  57
TYR U 151
GLY U 193
SER U 195
 4PG  U 300 (-3.9A)
None
4PG  U 300 (-4.1A)
4PG  U 300 (-3.5A)
 0.77A 4fu8A-2r2wU:
45.9		 4fu8A-2r2wU:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 HIS U  57
ASP U 189
VAL U 213
TRP U 215
GLY U 226
 4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.2A)
 0.42A 4hfpD-2r2wU:
35.0		 4hfpD-2r2wU:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens) 		5 / 12 HIS U  57
VAL U 213
TRP U 215
GLY U 216
GLY U 226
 4PG  U 300 (-3.9A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.32A 4rn6B-2r2wU:
30.3		 4rn6B-2r2wU:
29.70