SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4PA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 GLY A  92
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.87A 1ax9A-2o7rA:
18.5		 1ax9A-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.93A 1ax9A-2o7rA:
18.5		 1ax9A-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  91
GLY A  92
GLY A  93
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.25A 1dx6A-2o7rA:
19.1		 1dx6A-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 163
ALA A 166
GLU A 169
LEU A 170
LEU A  95
 None
None
None
None
4PA  A 701 (-4.2A)
 1.06A 1errB-1tqhA:
undetectable		 1errB-1tqhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 GLY A  91
GLU A 201
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.91A 1maaD-2o7rA:
18.4		 1maaD-2o7rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 GLY A  92
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.72A 1maaD-2o7rA:
18.4		 1maaD-2o7rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.78A 1maaD-2o7rA:
18.4		 1maaD-2o7rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.87A 1mx1D-2o7rA:
18.3		 1mx1D-2o7rA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.87A 1mx1F-2o7rA:
18.3		 1mx1F-2o7rA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		6 / 12 GLY A  91
GLY A  92
GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.63A 1qtiA-2o7rA:
18.3		 1qtiA-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  91
GLY A  92
GLY A  93
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.26A 1w6rA-2o7rA:
5.4		 1w6rA-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 11 GLY A  92
GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.49A 1w76A-2o7rA:
18.2		 1w76A-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 10 GLY A  91
GLY A  92
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.53A 1w76B-2o7rA:
18.1		 1w76B-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 10 GLY A  92
GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 1.18A 1w76B-2o7rA:
18.1		 1w76B-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLU A 168
ALA A 175
GLY A  93
GLY A  91
ILE A 230
 None
None
4PA  A 369 (-3.6A)
4PA  A 369 ( 3.8A)
4PA  A 369 ( 4.7A)
 1.14A 1x1aA-2o7rA:
2.2		 1x1aA-2o7rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 9 GLY A  24
SER A  94
LEU A  95
LEU A 167
HIS A 223
 4PA  A 701 (-3.6A)
4PA  A 701 (-1.4A)
4PA  A 701 (-4.2A)
None
4PA  A 701 (-4.4A)
 0.85A 1y7iA-1tqhA:
15.9		 1y7iA-1tqhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.82A 1ya4A-2o7rA:
18.4		 1ya4A-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.81A 1ya4B-2o7rA:
17.8		 1ya4B-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.78A 1ya4C-2o7rA:
18.3		 1ya4C-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		7 / 8 GLY A  91
GLY A  92
GLY A  93
SER A 169
ALA A 170
LEU A  22
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
4PA  A 369 (-3.2A)
None
4PA  A 369 (-4.8A)
 0.72A 1yajC-2o7rA:
5.7		 1yajC-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 8 GLY A  91
GLY A  92
SER A 169
ALA A 170
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-1.8A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
 0.93A 1yajC-2o7rA:
5.7		 1yajC-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 9 GLY A  91
GLY A  92
SER A 169
ALA A 170
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-1.8A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
 0.93A 2aceA-2o7rA:
19.2		 2aceA-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 9 GLY A  92
GLY A  93
SER A 169
ALA A 170
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
 0.47A 2aceA-2o7rA:
19.2		 2aceA-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 7 GLY A  92
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 (-3.5A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.94A 2ackA-2o7rA:
19.2		 2ackA-2o7rA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 223
VAL A  98
LEU A 178
ILE A 204
SER A 200
 4PA  A 701 (-4.4A)
None
None
None
None
 1.32A 2fj1A-1tqhA:
undetectable		 2fj1A-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 GLY A  92
GLY A  93
ALA A 170
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
 0.27A 2ha4A-2o7rA:
19.0		 2ha4A-2o7rA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 7 GLY A  92
GLY A  93
ALA A 170
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
 0.25A 2ha4B-2o7rA:
19.5		 2ha4B-2o7rA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 223
SER A  94
VAL A  98
ILE A 204
SER A 200
 4PA  A 701 (-4.4A)
4PA  A 701 (-1.4A)
None
None
None
 1.40A 2xpvA-1tqhA:
undetectable		 2xpvA-1tqhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 7 GLY A  92
GLY A  93
SER A 169
LEU A 227
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.50A 3o9mA-2o7rA:
19.4		 3o9mA-2o7rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 6 GLY A  92
GLY A  93
SER A 169
LEU A 227
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.53A 3o9mB-2o7rA:
19.4		 3o9mB-2o7rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 134
GLY A  27
ASP A  31
 None
4PA  A 701 (-3.5A)
4PA  A 701 (-4.1A)
 0.58A 3ou6C-1tqhA:
2.4		 3ou6C-1tqhA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 8 GLY A  91
GLY A  92
SER A 169
GLY A 203
ILE A 230
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-1.8A)
4PA  A 369 ( 3.7A)
4PA  A 369 ( 4.7A)
 1.08A 3v1nA-2o7rA:
16.4		 3v1nA-2o7rA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A  91
GLY A  92
GLY A  93
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.20A 4ey6A-2o7rA:
19.6		 4ey6A-2o7rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		6 / 12 GLY A  91
GLY A  92
GLY A  93
GLU A 168
SER A 169
HIS A 306
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
None
4PA  A 369 (-1.8A)
4PA  A 369 (-4.8A)
 0.48A 4ey6B-2o7rA:
5.8		 4ey6B-2o7rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 5 GLY A  96
SER A  94
ALA A 117
PHE A  99
 None
4PA  A 701 (-1.4A)
None
None
 0.99A 4m93B-1tqhA:
undetectable
4m93C-1tqhA:
undetectable		 4m93B-1tqhA:
19.85
4m93C-1tqhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLU A 168
GLY A  91
GLN A 282
GLY A 203
LEU A 222
 None
4PA  A 369 ( 3.8A)
None
4PA  A 369 ( 3.7A)
None
 1.27A 4uilH-2o7rA:
undetectable
4uilL-2o7rA:
undetectable		 4uilH-2o7rA:
20.53
4uilL-2o7rA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 GLY A 203
GLU A 201
PHE A  89
ARG A 125
ALA A 127
 4PA  A 369 ( 3.7A)
None
None
None
None
 1.19A 4wcxC-2o7rA:
2.1		 4wcxC-2o7rA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 7 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.70A 4zdzA-2o7rA:
undetectable		 4zdzA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 7 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.76A 4ze3A-2o7rA:
undetectable		 4ze3A-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 SER A 169
ALA A 170
HIS A 306
LEU A 227
 4PA  A 369 (-1.8A)
4PA  A 369 (-3.2A)
4PA  A 369 (-4.8A)
None
 1.21A 5dzkd-2o7rA:
2.8
5dzkr-2o7rA:
undetectable		 5dzkd-2o7rA:
24.93
5dzkr-2o7rA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.74A 5eseA-2o7rA:
undetectable		 5eseA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.73A 5esfA-2o7rA:
undetectable		 5esfA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.79A 5esjA-2o7rA:
undetectable		 5esjA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 7 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.69A 5esmA-2o7rA:
undetectable		 5esmA-2o7rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 8 PHE A 104
ILE A 103
GLY A  92
LEU A 222
 None
None
4PA  A 369 (-3.5A)
None
 0.81A 5hs1A-2o7rA:
undetectable		 5hs1A-2o7rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1tqh CARBOXYLESTERASE
PRECURSOR
(Geobacillus
stearothermophil
us) 		4 / 8 THR A  26
GLY A  27
GLY A  24
SER A  94
 None
4PA  A 701 (-3.5A)
4PA  A 701 (-3.6A)
4PA  A 701 (-1.4A)
 0.68A 5vw9A-1tqhA:
undetectable		 5vw9A-1tqhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		5 / 12 LEU A  96
GLY A  93
ILE A  38
GLY A  91
GLY A  92
 None
4PA  A 369 (-3.6A)
None
4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
 0.98A 5wyqB-2o7rA:
undetectable		 5wyqB-2o7rA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2o7r CXE CARBOXYLESTERASE
(Actinidia
eriantha) 		4 / 6 GLY A 205
ASP A 228
GLY A 203
PRO A 202
 None
None
4PA  A 369 ( 3.7A)
None
 0.76A 6ag0C-2o7rA:
undetectable		 6ag0C-2o7rA:
14.24