SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4OP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 12 GLY A 271
ALA A 102
ASP A 105
ILE A 301
ALA A 295
 None
None
None
None
4OP  A 416 (-4.0A)
 1.02A 1sguB-4izgA:
undetectable		 1sguB-4izgA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BUE_A_RIOA1201_0
(AAC(6')-IB)		 4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 11 TRP A 321
TYR A 326
TYR A  56
SER A  24
ASP A 242
 4OP  A 416 ( 3.8A)
None
4OP  A 416 (-4.4A)
None
MG  A 414 ( 3.1A)
 1.18A 2bueA-4izgA:
0.4		 2bueA-4izgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 12 TYR A 326
VAL A  52
TYR A  56
SER A  24
ASP A 194
 None
4OP  A 416 ( 4.7A)
4OP  A 416 (-4.4A)
None
MG  A 414 ( 2.6A)
 1.47A 2vqyA-4izgA:
undetectable		 2vqyA-4izgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 12 TYR A 326
VAL A  52
TYR A  56
SER A  24
ASP A 242
 None
4OP  A 416 ( 4.7A)
4OP  A 416 (-4.4A)
None
MG  A 414 ( 3.1A)
 1.29A 2vqyA-4izgA:
undetectable		 2vqyA-4izgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		4 / 4 ASN A 317
GLY A 309
ASP A 247
ASP A 293
 None
None
None
4OP  A 416 ( 4.8A)
 1.02A 4n49A-4izgA:
undetectable		 4n49A-4izgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		3 / 3 GLU A 243
ARG A 269
GLN A 162
 MG  A 414 ( 4.3A)
None
4OP  A 416 (-3.0A)
 0.97A 4rtbA-4izgA:
7.1		 4rtbA-4izgA:
23.81