SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4O0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_A_5D5A930_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	10 / 12	LEU A 79 ASP A 172 THR A 210 PHE A 211 LEU A 214 PRO A 259 ILE A 262 PHE A 275 TRP A 276 ARG A 285	None ZN A 904 ( 2.2A) ZN A 904 ( 2.6A) NKN A 909 ( 4.7A) 4O0 A 908 ( 4.4A) 4O0 A 908 ( 4.9A) None 4O0 A 908 (-3.7A) None None	0.64A	5dlvA-4zg7A: 59.4	5dlvA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_A_5D5A930_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	6 / 6	SER A 82 TYR A 83 LYS A 249 PHE A 250 TRP A 255 TRP A 261	4O0 A 908 ( 2.9A) None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A)	0.53A	5dlvA-4zg7A: 59.4	5dlvA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	11 / 12	LEU A 79 ASP A 172 THR A 210 PHE A 211 LEU A 214 PRO A 259 TRP A 261 ILE A 262 PHE A 275 TRP A 276 ARG A 285	None ZN A 904 ( 2.2A) ZN A 904 ( 2.6A) NKN A 909 ( 4.7A) 4O0 A 908 ( 4.4A) 4O0 A 908 ( 4.9A) 4O0 A 908 (-4.4A) None 4O0 A 908 (-3.7A) None None	0.59A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	6 / 12	LEU A 79 PRO A 259 TRP A 261 ILE A 262 TRP A 276 VAL A 279	None 4O0 A 908 ( 4.9A) 4O0 A 908 (-4.4A) None None GOL A 910 (-4.1A)	1.10A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	4 / 7	LYS A 249 HIS A 252 TRP A 255 TYR A 307	4O0 A 908 (-4.0A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) NKN A 909 (-3.6A)	1.27A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	5 / 7	SER A 82 TYR A 83 LYS A 249 PHE A 250 TRP A 255	4O0 A 908 ( 2.9A) None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.3A)	0.60A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLV_B_5D5B927_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	5 / 7	TYR A 83 LYS A 249 PHE A 250 HIS A 252 TRP A 255	None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A)	0.81A	5dlvB-4zg7A: 59.4	5dlvB-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	10 / 12	LEU A 79 SER A 82 PHE A 211 ARG A 247 LYS A 249 PHE A 250 TRP A 255 TRP A 261 PHE A 275 VAL A 278	None 4O0 A 908 ( 2.9A) NKN A 909 ( 4.7A) None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A) 4O0 A 908 (-3.7A) 4O0 A 908 ( 3.5A)	0.56A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	8 / 12	PHE A 211 ARG A 247 LYS A 249 PHE A 250 HIS A 252 TRP A 255 TRP A 261 PHE A 275	NKN A 909 ( 4.7A) None 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A) 4O0 A 908 (-3.7A)	0.73A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	6 / 12	PHE A 211 LYS A 249 PHE A 250 HIS A 252 TRP A 255 TYR A 307	NKN A 909 ( 4.7A) 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) NKN A 909 (-3.6A)	1.22A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	6 / 12	PHE A 211 LYS A 249 PHE A 250 TRP A 255 VAL A 278 TYR A 307	NKN A 909 ( 4.7A) 4O0 A 908 (-4.0A) 4O0 A 908 (-4.5A) 4O0 A 908 (-3.3A) 4O0 A 908 ( 3.5A) NKN A 909 (-3.6A)	1.50A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5DLW_A_5D5A905_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	5 / 12	SER A 277 PHE A 211 HIS A 252 TRP A 255 TRP A 261	GOL A 910 ( 4.4A) NKN A 909 ( 4.7A) 4O0 A 908 (-3.7A) 4O0 A 908 (-3.3A) 4O0 A 908 (-4.4A)	1.45A	5dlwA-4zg7A: 59.6	5dlwA-4zg7A: 92.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CNK_B_NCTB402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	4zg7	ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2 (Homo sapiens)	4 / 7	TYR A 215 CYH A 514 TYR A 510 TRP A 261	4O0 A 908 (-4.3A) None None 4O0 A 908 (-4.4A)	1.50A	6cnkB-4zg7A: undetectable 6cnkC-4zg7A: undetectable	6cnkB-4zg7A: 6.95 6cnkC-4zg7A: 8.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5DLV_A_5D5A930_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",10,"LEU A  79;ASP A 172;THR A 210;PHE A 211;LEU A 214;PRO A 259;ILE A 262;PHE A 275;TRP A 276;ARG A 285","None; ZN A 904 ( 2.2A); ZN A 904 ( 2.6A);NKN A 909 ( 4.7A);4O0 A 908 ( 4.4A);4O0 A 908 ( 4.9A);None;4O0 A 908 (-3.7A);None;None","0.64A","5dlvA-4zg7A:59.4",null],["5DLV_A_5D5A930_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",6,"SER A  82;TYR A  83;LYS A 249;PHE A 250;TRP A 255;TRP A 261","4O0 A 908 ( 2.9A);None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A)","0.53A","5dlvA-4zg7A:59.4","5dlvA-4zg7A:92.72"],["5DLV_B_5D5B927_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",11,"LEU A  79;ASP A 172;THR A 210;PHE A 211;LEU A 214;PRO A 259;TRP A 261;ILE A 262;PHE A 275;TRP A 276;ARG A 285","None; ZN A 904 ( 2.2A); ZN A 904 ( 2.6A);NKN A 909 ( 4.7A);4O0 A 908 ( 4.4A);4O0 A 908 ( 4.9A);4O0 A 908 (-4.4A);None;4O0 A 908 (-3.7A);None;None","0.59A","5dlvB-4zg7A:59.4","5dlvA-4zg7A:92.72"],["5DLV_B_5D5B927_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",6,"LEU A  79;PRO A 259;TRP A 261;ILE A 262;TRP A 276;VAL A 279","None;4O0 A 908 ( 4.9A);4O0 A 908 (-4.4A);None;None;GOL A 910 (-4.1A)","1.10A","5dlvB-4zg7A:59.4","5dlvB-4zg7A:92.72"],["5DLV_B_5D5B927_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",4,"LYS A 249;HIS A 252;TRP A 255;TYR A 307","4O0 A 908 (-4.0A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);NKN A 909 (-3.6A)","1.27A","5dlvB-4zg7A:59.4","5dlvB-4zg7A:92.72"],["5DLV_B_5D5B927_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",5,"SER A  82;TYR A  83;LYS A 249;PHE A 250;TRP A 255","4O0 A 908 ( 2.9A);None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.3A)","0.60A","5dlvB-4zg7A:59.4","5dlvB-4zg7A:92.72"],["5DLV_B_5D5B927_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",5,"TYR A  83;LYS A 249;PHE A 250;HIS A 252;TRP A 255","None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A)","0.81A","5dlvB-4zg7A:59.4","5dlvB-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",10,"LEU A  79;SER A  82;PHE A 211;ARG A 247;LYS A 249;PHE A 250;TRP A 255;TRP A 261;PHE A 275;VAL A 278","None;4O0 A 908 ( 2.9A);NKN A 909 ( 4.7A);None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A);4O0 A 908 (-3.7A);4O0 A 908 ( 3.5A)","0.56A","5dlwA-4zg7A:59.6","5dlvB-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",8,"PHE A 211;ARG A 247;LYS A 249;PHE A 250;HIS A 252;TRP A 255;TRP A 261;PHE A 275","NKN A 909 ( 4.7A);None;4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A);4O0 A 908 (-3.7A)","0.73A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",6,"PHE A 211;LYS A 249;PHE A 250;HIS A 252;TRP A 255;TYR A 307","NKN A 909 ( 4.7A);4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);NKN A 909 (-3.6A)","1.22A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",6,"PHE A 211;LYS A 249;PHE A 250;TRP A 255;VAL A 278;TYR A 307","NKN A 909 ( 4.7A);4O0 A 908 (-4.0A);4O0 A 908 (-4.5A);4O0 A 908 (-3.3A);4O0 A 908 ( 3.5A);NKN A 909 (-3.6A)","1.50A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["5DLW_A_5D5A905_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",5,"SER A 277;PHE A 211;HIS A 252;TRP A 255;TRP A 261","GOL A 910 ( 4.4A);NKN A 909 ( 4.7A);4O0 A 908 (-3.7A);4O0 A 908 (-3.3A);4O0 A 908 (-4.4A)","1.45A","5dlwA-4zg7A:59.6","5dlwA-4zg7A:92.72"],["6CNK_B_NCTB402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","4zg7","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","Homo sapiens",4,"TYR A 215;CYH A 514;TYR A 510;TRP A 261","4O0 A 908 (-4.3A);None;None;4O0 A 908 (-4.4A)","1.50A","6cnkB-4zg7A:undetectable;6cnkC-4zg7A:undetectable","5dlwA-4zg7A:92.72"]]