SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4NS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST
(Escherichia
coli) 		5 / 11 ILE A 503
ASN A 358
SER A 519
GLY A 518
GLY A 517
 None
4NS  A 601 (-3.6A)
None
None
None
 1.46A 1ho5A-4p05A:
undetectable		 1ho5A-4p05A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST
(Escherichia
coli) 		4 / 5 SER A 519
SER A 498
THR A 501
ASN A 436
 None
None
4NS  A 601 (-4.2A)
4NS  A 601 (-3.3A)
 1.40A 1yvpA-4p05A:
undetectable		 1yvpA-4p05A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST
(Escherichia
coli) 		4 / 8 ASN A 353
ILE A 500
SER A 373
THR A 434
 None
4NS  A 601 (-3.7A)
None
None
 0.93A 2yoeB-4p05A:
undetectable
2yoeC-4p05A:
undetectable		 2yoeB-4p05A:
21.23
2yoeC-4p05A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST
(Escherichia
coli) 		5 / 12 GLY A 517
ASN A 436
ASP A 450
ARG A 455
TYR A 497
 None
4NS  A 601 (-3.3A)
None
None
None
 1.42A 3a27A-4p05A:
undetectable		 3a27A-4p05A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST
(Escherichia
coli) 		5 / 12 LEU A 316
ALA A 392
ASN A 358
ASN A 436
GLY A 452
 None
None
4NS  A 601 (-3.6A)
4NS  A 601 (-3.3A)
None
 0.87A 4r3aB-4p05A:
undetectable		 4r3aB-4p05A:
20.84