SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4KZ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT4_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	4ypl	LON PROTEASE (Meiothermus taiwanensis)	5 / 12	LEU A 610 ALA A 639 ALA A 637 VAL A 667 MET A 633	4KZ A 801 (-4.2A) None None None 4KZ A 801 (-3.6A)	1.26A	1kt4A-4yplA: undetectable	1kt4A-4yplA: 16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YPM_A_BO2A801_1 (LON PROTEASE)	4ypl	LON PROTEASE (Meiothermus taiwanensis)	12 / 12	ALA A 601 THR A 603 THR A 608 LEU A 610 MET A 633 THR A 672 LYS A 674 GLY A 676 PRO A 677 SER A 678 ALA A 679 LYS A 721	4KZ A 801 (-3.3A) 4KZ A 801 ( 4.5A) None 4KZ A 801 (-4.2A) 4KZ A 801 (-3.6A) None None 4KZ A 801 (-3.3A) 4KZ A 801 (-4.3A) 4KZ A 801 (-1.4A) 4KZ A 801 (-3.5A) 4KZ A 801 (-3.4A)	0.57A	4ypmA-4yplA: 34.6	4ypmA-4yplA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_NPSA603_1 (SERUM ALBUMIN)	4ypl	LON PROTEASE (Meiothermus taiwanensis)	5 / 10	ALA A 684 LEU A 769 ALA A 597 SER A 678 ALA A 679	None None None 4KZ A 801 (-1.4A) 4KZ A 801 (-3.5A)	1.12A	4zbrA-4yplA: 2.2	4zbrA-4yplA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IMS_B_ACTB713_0 (ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL)	4ypl	LON PROTEASE (Meiothermus taiwanensis)	3 / 3	GLY A 716 GLN A 742 LYS A 721	None None 4KZ A 801 (-3.4A)	0.84A	5imsB-4yplA: undetectable	5imsB-4yplA: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MVX_A_K4DA1304_0 (ION TRANSPORT PROTEIN)	4ypl	LON PROTEASE (Meiothermus taiwanensis)	4 / 6	MET A 683 THR A 682 MET A 633 LEU A 735	None None 4KZ A 801 (-3.6A) None	1.21A	6mvxA-4yplA: undetectable 6mvxB-4yplA: undetectable 6mvxC-4yplA: undetectable	6mvxA-4yplA: 20.00 6mvxB-4yplA: 20.00 6mvxC-4yplA: 20.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KT4_A_RTLA184_0","PLASMA RETINOL-BINDING PROTEIN","4ypl","LON PROTEASE","Meiothermus taiwanensis",5,"LEU A 610;ALA A 639;ALA A 637;VAL A 667;MET A 633","4KZ A 801 (-4.2A);None;None;None;4KZ A 801 (-3.6A)","1.26A","1kt4A-4yplA:undetectable",null],["4YPM_A_BO2A801_1","LON PROTEASE","4ypl","LON PROTEASE","Meiothermus taiwanensis",12,"ALA A 601;THR A 603;THR A 608;LEU A 610;MET A 633;THR A 672;LYS A 674;GLY A 676;PRO A 677;SER A 678;ALA A 679;LYS A 721","4KZ A 801 (-3.3A);4KZ A 801 ( 4.5A);None;4KZ A 801 (-4.2A);4KZ A 801 (-3.6A);None;None;4KZ A 801 (-3.3A);4KZ A 801 (-4.3A);4KZ A 801 (-1.4A);4KZ A 801 (-3.5A);4KZ A 801 (-3.4A)","0.57A","4ypmA-4yplA:34.6","1kt4A-4yplA:16.14"],["4ZBR_A_NPSA603_1","SERUM ALBUMIN","4ypl","LON PROTEASE","Meiothermus taiwanensis",5,"ALA A 684;LEU A 769;ALA A 597;SER A 678;ALA A 679","None;None;None;4KZ A 801 (-1.4A);4KZ A 801 (-3.5A)","1.12A","4zbrA-4yplA:2.2","4ypmA-4yplA:100.00"],["5IMS_B_ACTB713_0","ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL","4ypl","LON PROTEASE","Meiothermus taiwanensis",3,"GLY A 716;GLN A 742;LYS A 721","None;None;4KZ A 801 (-3.4A)","0.84A","5imsB-4yplA:undetectable","4zbrA-4yplA:22.66"],["6MVX_A_K4DA1304_0","ION TRANSPORT PROTEIN","4ypl","LON PROTEASE","Meiothermus taiwanensis",4,"MET A 683;THR A 682;MET A 633;LEU A 735","None;None;4KZ A 801 (-3.6A);None","1.21A","6mvxA-4yplA:undetectable;6mvxB-4yplA:undetectable;6mvxC-4yplA:undetectable","5imsB-4yplA:23.25"]]