SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4KM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5avi OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens) 		5 / 9 LEU A 414
ILE A 339
GLU A 341
PHE A 342
GLU A 301
 None
4KM  A 501 ( 4.0A)
None
None
None
 1.49A 5igzA-5aviA:
undetectable		 5igzA-5aviA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5avi OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
 4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
 0.82A 6e43A-5aviA:
undetectable		 6e43A-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5avi OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
 4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
 0.83A 6e43B-5aviA:
undetectable		 6e43B-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5avi OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
 4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
 0.85A 6e43C-5aviA:
undetectable		 6e43C-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5avi OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens) 		4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
 4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
 0.82A 6e43D-5aviA:
undetectable		 6e43D-5aviA:
22.60