SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4KL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_A_SFYA807_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 11	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206 MET A 215	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A) None	0.55A	4hwkA-4z3kA: 45.3	4hwkA-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 11	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206	None 4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A)	0.32A	4hwkB-4z3kA: 45.3	4hwkB-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	12 / 12	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206 MET A 215	None 4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A) None	0.50A	4hwkC-4z3kA: 45.5	4hwkC-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 11	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206	None 4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A)	0.27A	4hwkD-4z3kA: 45.5	4hwkD-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7U_A_YTZA802_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	10 / 10	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 MET A 215	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) None	0.58A	4j7uA-4z3kA: 45.3	4j7uA-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7U_B_YTZB802_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	10 / 10	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 MET A 215	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) None	0.57A	4j7uB-4z3kA: 45.4	4j7uB-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7U_C_YTZC802_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	10 / 10	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 MET A 215	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) NAP A 801 (-3.5A) 4KL A 802 ( 3.2A) None	0.57A	4j7uC-4z3kA: 45.2	4j7uC-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7U_D_YTZD802_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	8 / 8	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 GLN A 203	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A)	0.32A	4j7uD-4z3kA: 45.3	4j7uD-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_A_SASA806_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 12	SER A 154 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 GLN A 203 ALA A 206 ASP A 214 MET A 215 GLY A 218	4KL A 802 (-2.6A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A) None None None	0.63A	4j7xA-4z3kA: 45.1	4j7xA-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_A_SASA806_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	7 / 12	SER A 154 LEU A 155 CYH A 156 PHE A 161 PRO A 197 GLN A 203 ASP A 212	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) None	1.08A	4j7xA-4z3kA: 45.1	4j7xA-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_A_SASA806_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 12	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 GLN A 203 ALA A 206 MET A 215 GLY A 218	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A) None None	0.56A	4j7xA-4z3kA: 45.1	4j7xA-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_B_SASB804_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	12 / 12	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 GLN A 203 ALA A 206 MET A 215 GLY A 218 LEU A 219	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) 4KL A 802 ( 4.3A) None None 4KL A 802 (-4.9A)	0.47A	4j7xB-4z3kA: 45.2	4j7xB-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_F_SASF805_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	12 / 12	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 GLN A 203 ASP A 212 ASP A 214 MET A 215 GLY A 218	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) None None None None	0.69A	4j7xF-4z3kA: 45.0	4j7xF-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_F_SASF805_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	6 / 12	SER A 154 LEU A 155 PHE A 161 PRO A 197 GLN A 203 ASP A 212	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) None 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) None	1.16A	4j7xF-4z3kA: 45.0	4j7xF-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_J_SASJ804_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	12 / 12	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 GLN A 203 ASP A 212 ASP A 214 MET A 215	None 4KL A 802 (-2.6A) 4KL A 802 (-4.0A) 4KL A 802 ( 4.2A) None None 4KL A 802 ( 4.1A) 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) None None None	0.60A	4j7xJ-4z3kA: 45.3	4j7xJ-4z3kA: 94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4J7X_J_SASJ804_1 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	6 / 12	SER A 154 LEU A 155 PHE A 161 PRO A 197 GLN A 203 ASP A 212	4KL A 802 (-2.6A) 4KL A 802 (-4.0A) None 4KL A 802 (-4.0A) 4KL A 802 ( 3.2A) None	1.05A	4j7xJ-4z3kA: 45.3	4j7xJ-4z3kA: 94.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4HWK_A_SFYA807_0","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",11,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;ALA A 206;MET A 215","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A);None","0.55A","4hwkA-4z3kA:45.3",null],["4HWK_B_SFYB806_0","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",11,"LEU A 101;SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;ALA A 206","None;4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A)","0.32A","4hwkB-4z3kA:45.3","4hwkA-4z3kA:94.44"],["4HWK_C_SFYC804_0","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",12,"LEU A 101;SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;ALA A 206;MET A 215","None;4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A);None","0.50A","4hwkC-4z3kA:45.5","4hwkB-4z3kA:94.44"],["4HWK_D_SFYD803_0","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",11,"LEU A 101;SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;ALA A 206","None;4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A)","0.27A","4hwkD-4z3kA:45.5","4hwkC-4z3kA:94.44"],["4J7U_A_YTZA802_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",10,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;MET A 215","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);None","0.58A","4j7uA-4z3kA:45.3","4hwkD-4z3kA:94.44"],["4J7U_B_YTZB802_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",10,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;MET A 215","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);None","0.57A","4j7uB-4z3kA:45.4","4j7uA-4z3kA:94.44"],["4J7U_C_YTZC802_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",10,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;MET A 202;GLN A 203;MET A 215","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);NAP A 801 (-3.5A);4KL A 802 ( 3.2A);None","0.57A","4j7uC-4z3kA:45.2","4j7uB-4z3kA:94.44"],["4J7U_D_YTZD802_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",8,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;GLN A 203","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);4KL A 802 ( 3.2A)","0.32A","4j7uD-4z3kA:45.3","4j7uC-4z3kA:94.44"],["4J7X_A_SASA806_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",11,"SER A 154;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;GLN A 203;ALA A 206;ASP A 214;MET A 215;GLY A 218","4KL A 802 (-2.6A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A);None;None;None","0.63A","4j7xA-4z3kA:45.1","4j7uD-4z3kA:94.44"],["4J7X_A_SASA806_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",7,"SER A 154;LEU A 155;CYH A 156;PHE A 161;PRO A 197;GLN A 203;ASP A 212","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;4KL A 802 (-4.0A);4KL A 802 ( 3.2A);None","1.08A","4j7xA-4z3kA:45.1","4j7xA-4z3kA:94.44"],["4J7X_A_SASA806_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",11,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;GLN A 203;ALA A 206;MET A 215;GLY A 218","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A);None;None","0.56A","4j7xA-4z3kA:45.1","4j7xA-4z3kA:94.44"],["4J7X_B_SASB804_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",12,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;GLN A 203;ALA A 206;MET A 215;GLY A 218;LEU A 219","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);4KL A 802 ( 3.2A);4KL A 802 ( 4.3A);None;None;4KL A 802 (-4.9A)","0.47A","4j7xB-4z3kA:45.2","4j7xA-4z3kA:94.44"],["4J7X_F_SASF805_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",12,"SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;GLN A 203;ASP A 212;ASP A 214;MET A 215;GLY A 218","4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);4KL A 802 ( 3.2A);None;None;None;None","0.69A","4j7xF-4z3kA:45.0","4j7xB-4z3kA:94.44"],["4J7X_F_SASF805_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",6,"SER A 154;LEU A 155;PHE A 161;PRO A 197;GLN A 203;ASP A 212","4KL A 802 (-2.6A);4KL A 802 (-4.0A);None;4KL A 802 (-4.0A);4KL A 802 ( 3.2A);None","1.16A","4j7xF-4z3kA:45.0","4j7xF-4z3kA:94.44"],["4J7X_J_SASJ804_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",12,"LEU A 101;SER A 154;LEU A 155;CYH A 156;PHE A 161;TRP A 164;TYR A 167;PRO A 197;GLN A 203;ASP A 212;ASP A 214;MET A 215","None;4KL A 802 (-2.6A);4KL A 802 (-4.0A);4KL A 802 ( 4.2A);None;None;4KL A 802 ( 4.1A);4KL A 802 (-4.0A);4KL A 802 ( 3.2A);None;None;None","0.60A","4j7xJ-4z3kA:45.3","4j7xF-4z3kA:94.44"],["4J7X_J_SASJ804_1","SEPIAPTERIN REDUCTASE","4z3k","SEPIAPTERIN REDUCTASE","Homo sapiens",6,"SER A 154;LEU A 155;PHE A 161;PRO A 197;GLN A 203;ASP A 212","4KL A 802 (-2.6A);4KL A 802 (-4.0A);None;4KL A 802 (-4.0A);4KL A 802 ( 3.2A);None","1.05A","4j7xJ-4z3kA:45.3","4j7xJ-4z3kA:94.44"]]