SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4IP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2r09 CYTOHESIN-3
(Mus
musculus) 		4 / 5 TYR A 295
GLU A 297
PRO A 304
ASP A 301
 4IP  A 405 (-4.5A)
None
None
SO4  A 404 (-4.2A)
 1.47A 1i7zB-2r09A:
0.0		 1i7zB-2r09A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus) 		4 / 5 TYR A 295
GLU A 297
PRO A 304
ASP A 301
 4IP  A 603 (-4.5A)
None
None
None
 1.37A 1i7zB-6bbpA:
undetectable		 1i7zB-6bbpA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		4 / 8 ARG A1075
LYS A1063
SER A1098
ARG A1129
 4IP  A2154 (-3.6A)
4IP  A2154 (-2.5A)
None
4IP  A2154 (-2.5A)
 1.20A 1u1jA-1uprA:
undetectable		 1u1jA-1uprA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1b55 TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens) 		4 / 6 ASP A  57
ILE A  56
GLN A  15
GLU A 108
 None
None
4IP  A 171 (-4.6A)
None
 1.29A 2ya7C-1b55A:
0.0		 2ya7C-1b55A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1b55 TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens) 		3 / 3 SER A  21
GLU A 108
ASP A  57
 4IP  A 171 (-2.5A)
None
None
 0.81A 2zulA-1b55A:
undetectable		 2zulA-1b55A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1b55 TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens) 		3 / 3 SER A  21
GLU A 108
ASP A  57
 4IP  A 171 (-2.5A)
None
None
 0.80A 3dmhA-1b55A:
undetectable		 3dmhA-1b55A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus) 		4 / 5 ASP A 301
TYR A 295
PRO A 304
GLU A 303
 None
4IP  A 603 (-4.5A)
None
None
 1.47A 3l2wA-6bbpA:
0.6		 3l2wA-6bbpA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		3 / 3 ASP A1065
ARG A1075
LYS A1063
 4IP  A2154 (-3.7A)
4IP  A2154 (-3.6A)
4IP  A2154 (-2.5A)
 1.24A 3wipG-1uprA:
undetectable		 3wipG-1uprA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.36A 4dajB-1uprA:
undetectable		 4dajB-1uprA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1u27 CYTOHESIN 2
(Mus
musculus) 		5 / 12 TYR A 291
PHE A 282
LEU A 325
LEU A 289
HIS A 351
 4IP  A 101 (-4.6A)
None
None
None
4IP  A 101 (-3.8A)
 1.32A 4j03A-1u27A:
undetectable		 4j03A-1u27A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2r09 CYTOHESIN-3
(Mus
musculus) 		5 / 12 TYR A 295
PHE A 286
LEU A 329
LEU A 293
HIS A 355
 4IP  A 405 (-4.5A)
None
None
None
4IP  A 405 (-3.9A)
 1.36A 4j03A-2r09A:
undetectable		 4j03A-2r09A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.45A 4u15A-1uprA:
undetectable		 4u15A-1uprA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.47A 5dsgA-1uprA:
undetectable		 5dsgA-1uprA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1b55 TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens) 		3 / 3 TYR A 106
TYR A  39
GLN A  15
 None
4IP  A 171 (-4.6A)
4IP  A 171 (-4.6A)
 1.17A 5jsdA-1b55A:
0.0
5jsdB-1b55A:
0.0		 5jsdA-1b55A:
11.66
5jsdB-1b55A:
11.66