SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4IG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 11 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.73A 1hxwB-2g1sA:
7.8		 1hxwB-2g1sA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.79A 1rl8B-2g1sA:
7.7		 1rl8B-2g1sA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 10 LEU A 219
ASP A 221
GLY A 223
ALA A 224
THR A 307
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.87A 1t7iA-2g1sA:
7.5		 1t7iA-2g1sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 11 LEU A 219
ASP A 221
GLY A 223
ALA A 224
THR A 307
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.87A 1t7jA-2g1sA:
7.3		 1t7jA-2g1sA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 10 PHE A 155
TYR A 157
GLY A 124
ASP A  33
THR A 320
 None
None
None
4IG  A 885 (-2.7A)
None
 1.45A 2b82A-2g1sA:
undetectable		 2b82A-2g1sA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.77A 2nmzB-2g1sA:
8.0		 2nmzB-2g1sA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.76A 2q63A-2g1sA:
8.2		 2q63A-2g1sA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.68A 2rkfB-2g1sA:
8.3		 2rkfB-2g1sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.70A 2rkgA-2g1sA:
8.3		 2rkgA-2g1sA:
14.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 ASP A 221
GLY A 223
PRO A 301
ASP A  33
GLY A  35
 4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
None
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
 0.91A 2v0zC-2g1sA:
55.4		 2v0zC-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		12 / 12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
SER A  36
TYR A  78
PRO A 113
PHE A 119
VAL A 122
ASP A 221
GLY A 223
SER A 225
 4IG  A 885 (-3.2A)
4IG  A 885 (-4.3A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-4.7A)
None
4IG  A 885 ( 4.4A)
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 (-3.1A)
 0.45A 2v0zC-2g1sA:
55.4		 2v0zC-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		12 / 12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
ALA A 117
PHE A 119
VAL A 122
GLN A 130
ASP A 221
GLY A 223
SER A 225
ILE A 300
 4IG  A 885 (-3.2A)
4IG  A 885 (-4.3A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 ( 4.6A)
None
4IG  A 885 ( 4.4A)
None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 (-3.1A)
None
 0.49A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		7 / 8 TYR A  15
SER A  36
TYR A  78
SER A  79
THR A  80
PRO A 113
LEU A 116
 None
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
4IG  A 885 (-4.7A)
4IG  A 885 (-3.5A)
 0.64A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 8 TYR A  15
SER A  36
TYR A  78
SER A  79
THR A 304
 None
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-3.0A)
None
 0.65A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_2
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		4 / 8 TYR A  16
SER A  36
SER A  79
THR A  80
 None
4IG  A 885 ( 4.8A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
 0.90A 2v0zO-2g1sA:
53.2		 2v0zO-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		8 / 12 ASP A  33
GLY A  35
SER A  79
PHE A 119
LEU A 219
ASP A 221
SER A 228
ALA A 309
 4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 (-3.0A)
None
None
4IG  A 885 (-2.6A)
None
None
 0.73A 3d91A-2g1sA:
54.2		 3d91A-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		10 / 12 GLN A  14
ASP A  33
GLY A  35
THR A  80
PHE A 119
LEU A 219
ASP A 221
SER A 225
SER A 228
ALA A 309
 4IG  A 885 (-3.2A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 (-3.5A)
None
None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.1A)
None
None
 0.46A 3d91A-2g1sA:
54.2		 3d91A-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 GLY A  35
PHE A 114
LEU A 219
SER A 228
ALA A 309
 4IG  A 885 (-3.5A)
4IG  A 885 ( 4.8A)
None
None
None
 1.12A 3d91A-2g1sA:
54.2		 3d91A-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_2
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		4 / 5 ALA A 117
ALA A 224
TYR A 226
MET A 298
 4IG  A 885 ( 4.6A)
4IG  A 885 ( 4.7A)
None
None
 0.72A 3d91A-2g1sA:
54.2		 3d91A-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_A_REMA350_2
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		4 / 5 TYR A  78
ALA A 117
ALA A 224
MET A 298
 4IG  A 885 (-4.0A)
4IG  A 885 ( 4.6A)
4IG  A 885 ( 4.7A)
None
 0.49A 3d91A-2g1sA:
54.2		 3d91A-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		8 / 12 ASP A  33
GLY A  35
SER A  79
THR A  80
VAL A  31
LEU A 219
ASP A 221
SER A 228
 4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
4IG  A 885 (-4.3A)
None
4IG  A 885 (-2.6A)
None
 1.36A 3d91B-2g1sA:
53.6		 3d91B-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_1
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		11 / 12 GLN A  14
ASP A  33
GLY A  35
SER A  79
THR A  80
VAL A 122
LEU A 219
ASP A 221
ALA A 224
SER A 225
SER A 228
 4IG  A 885 (-3.2A)
4IG  A 885 (-2.7A)
4IG  A 885 (-3.5A)
4IG  A 885 (-3.0A)
4IG  A 885 (-3.5A)
4IG  A 885 ( 4.4A)
None
4IG  A 885 (-2.6A)
4IG  A 885 ( 4.7A)
4IG  A 885 (-3.1A)
None
 0.55A 3d91B-2g1sA:
53.6		 3d91B-2g1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D91_B_REMB350_2
(RENIN)		 2g1s RENIN
(Homo
sapiens) 		4 / 4 VAL A  31
TYR A  78
PRO A 113
PHE A 119
 4IG  A 885 (-4.3A)
4IG  A 885 (-4.0A)
4IG  A 885 (-4.7A)
None
 0.57A 3d91B-2g1sA:
53.6		 3d91B-2g1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.68A 3k4vA-2g1sA:
8.1		 3k4vA-2g1sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.70A 3k4vB-2g1sA:
8.1		 3k4vB-2g1sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.72A 3ndtA-2g1sA:
7.7		 3ndtA-2g1sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.68A 3ndtB-2g1sA:
8.2		 3ndtB-2g1sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.64A 3nduD-2g1sA:
7.7		 3nduD-2g1sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2g1s RENIN
(Homo
sapiens) 		4 / 8 GLY A  35
SER A  36
TYR A  78
ASP A 221
 4IG  A 885 (-3.5A)
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-2.6A)
 0.22A 3pwwA-2g1sA:
37.8		 3pwwA-2g1sA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.69A 3tl9A-2g1sA:
7.8		 3tl9A-2g1sA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 12 LEU A 219
ASP A 221
GLY A 223
ALA A 224
PRO A 301
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.68A 3tl9B-2g1sA:
7.7		 3tl9B-2g1sA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 VAL A  31
GLY A  17
LYS A  29
 4IG  A 885 (-4.3A)
None
None
 0.66A 4k50A-2g1sA:
undetectable		 4k50A-2g1sA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 VAL A  31
GLY A  17
LYS A  29
 4IG  A 885 (-4.3A)
None
None
 0.71A 4k50E-2g1sA:
undetectable		 4k50E-2g1sA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 VAL A  31
GLY A  17
LYS A  29
 4IG  A 885 (-4.3A)
None
None
 0.67A 4k50I-2g1sA:
undetectable		 4k50I-2g1sA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.87A 4k8cA-2g1sA:
undetectable		 4k8cA-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.85A 4kahA-2g1sA:
undetectable		 4kahA-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.86A 4kahB-2g1sA:
undetectable		 4kahB-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.85A 4kanA-2g1sA:
undetectable		 4kanA-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.88A 4kanB-2g1sA:
undetectable		 4kanB-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.90A 4kbeA-2g1sA:
undetectable		 4kbeA-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.88A 4kbeB-2g1sA:
undetectable		 4kbeB-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.86A 4lbgA-2g1sA:
undetectable		 4lbgA-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 SER A  36
TYR A  78
PRO A 137
 4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
None
 0.84A 4lbgB-2g1sA:
undetectable		 4lbgB-2g1sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 10 LEU A 219
ASP A 221
GLY A 223
ALA A 224
THR A 307
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.81A 4njtB-2g1sA:
8.1		 4njtB-2g1sA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		5 / 9 LEU A 219
ASP A 221
GLY A 223
ALA A 224
THR A 307
 None
4IG  A 885 (-2.6A)
4IG  A 885 (-3.9A)
4IG  A 885 ( 4.7A)
None
 0.83A 4njtD-2g1sA:
8.1		 4njtD-2g1sA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2g1s RENIN
(Homo
sapiens) 		3 / 3 ASP A 221
ASP A  33
ASN A  38
 4IG  A 885 (-2.6A)
4IG  A 885 (-2.7A)
None
 0.60A 4q5mA-2g1sA:
10.6		 4q5mA-2g1sA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2g1s RENIN
(Homo
sapiens) 		6 / 12 GLY A 223
GLY A  35
GLY A 124
ALA A 312
THR A 313
ALA A 224
 4IG  A 885 (-3.9A)
4IG  A 885 (-3.5A)
None
None
None
4IG  A 885 ( 4.7A)
 1.24A 4uckA-2g1sA:
undetectable		 4uckA-2g1sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2g1s RENIN
(Homo
sapiens) 		6 / 12 GLY A 223
GLY A  35
GLY A 124
ASN A  38
ALA A 312
THR A 313
 4IG  A 885 (-3.9A)
4IG  A 885 (-3.5A)
None
None
None
None
 1.31A 4uckA-2g1sA:
undetectable		 4uckA-2g1sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2g1s RENIN
(Homo
sapiens) 		4 / 8 THR A  34
SER A  79
ALA A 309
SER A 228
 None
4IG  A 885 (-3.0A)
None
None
 1.11A 5l5fY-2g1sA:
undetectable
5l5fZ-2g1sA:
undetectable		 5l5fY-2g1sA:
22.04
5l5fZ-2g1sA:
22.69