SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4FD'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	12 / 12	LEU A 87 SER A 88 PRO A 89 GLN A 90 GLY A 113 SER A 132 ILE A 133 VAL A 137 LEU A 138 GLY A 140 GLY A 141 PRO A 144	None None 4FD A 301 ( 3.6A) None 4FD A 301 (-4.7A) 4FD A 301 (-3.2A) 4FD A 301 (-4.1A) 4FD A 301 ( 4.4A) 4FD A 301 (-3.9A) 4FD A 301 (-3.6A) 4FD A 301 (-3.9A) 4FD A 301 (-4.5A)	0.36A	1uakA-4ypwA: 31.4	1uakA-4ypwA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	6 / 12	PRO A 89 GLN A 90 GLY A 113 LEU A 138 GLY A 141 PRO A 144	4FD A 301 ( 3.6A) None 4FD A 301 (-4.7A) 4FD A 301 (-3.9A) 4FD A 301 (-3.9A) 4FD A 301 (-4.5A)	1.21A	1uakA-4ypwA: 31.4	1uakA-4ypwA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	6 / 12	SER A 88 PRO A 89 GLN A 90 GLY A 113 LEU A 138 GLY A 140	None 4FD A 301 ( 3.6A) None 4FD A 301 (-4.7A) 4FD A 301 (-3.9A) 4FD A 301 (-3.6A)	1.26A	1uakA-4ypwA: 31.4	1uakA-4ypwA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	4 / 6	VAL A 33 VAL A 99 ILE A 133 ASP A 150	None None 4FD A 301 (-4.1A) None	0.82A	1uwhA-4ypwA: undetectable	1uwhA-4ypwA: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_A_SAMA301_0 (UPF0217 PROTEIN AF_1056)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	5 / 9	LEU A 87 GLY A 113 GLY A 117 SER A 132 LEU A 138	None 4FD A 301 (-4.7A) 4FD A 301 (-3.6A) 4FD A 301 (-3.2A) 4FD A 301 (-3.9A)	0.80A	2qmmA-4ypwA: 8.8	2qmmA-4ypwA: 24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_B_SAMB301_0 (UPF0217 PROTEIN AF_1056)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	5 / 11	LEU A 87 GLY A 113 GLY A 117 SER A 132 LEU A 138	None 4FD A 301 (-4.7A) 4FD A 301 (-3.6A) 4FD A 301 (-3.2A) 4FD A 301 (-3.9A)	0.88A	2qmmA-4ypwA: 5.5 2qmmB-4ypwA: 5.7	2qmmA-4ypwA: 24.24 2qmmB-4ypwA: 24.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	12 / 12	TYR A 86 LEU A 87 SER A 88 PRO A 89 GLY A 113 GLY A 117 SER A 132 ILE A 133 LEU A 138 GLY A 140 GLY A 141 PRO A 144	None None None 4FD A 301 ( 3.6A) 4FD A 301 (-4.7A) 4FD A 301 (-3.6A) 4FD A 301 (-3.2A) 4FD A 301 (-4.1A) 4FD A 301 (-3.9A) 4FD A 301 (-3.6A) 4FD A 301 (-3.9A) 4FD A 301 (-4.5A)	0.31A	3axzA-4ypwA: 31.4	3axzA-4ypwA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	12 / 12	LEU A 87 SER A 88 PRO A 89 GLY A 113 GLU A 116 GLY A 117 SER A 132 ILE A 133 LEU A 138 GLY A 140 GLY A 141 PRO A 144	None None 4FD A 301 ( 3.6A) 4FD A 301 (-4.7A) None 4FD A 301 (-3.6A) 4FD A 301 (-3.2A) 4FD A 301 (-4.1A) 4FD A 301 (-3.9A) 4FD A 301 (-3.6A) 4FD A 301 (-3.9A) 4FD A 301 (-4.5A)	0.34A	4yvgA-4ypwA: 31.6	4yvgA-4ypwA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_A_SAMA201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	5 / 12	LEU A 87 GLY A 113 GLY A 117 SER A 132 LEU A 138	None 4FD A 301 (-4.7A) 4FD A 301 (-3.6A) 4FD A 301 (-3.2A) 4FD A 301 (-3.9A)	0.73A	5twjA-4ypwA: 11.0	5twjA-4ypwA: 20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_A_SAMA401_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	12 / 12	LEU A 87 PRO A 89 GLN A 90 GLY A 113 GLY A 117 SER A 132 ILE A 133 VAL A 137 LEU A 138 GLY A 140 GLY A 141 PRO A 144	None 4FD A 301 ( 3.6A) None 4FD A 301 (-4.7A) 4FD A 301 (-3.6A) 4FD A 301 (-3.2A) 4FD A 301 (-4.1A) 4FD A 301 ( 4.4A) 4FD A 301 (-3.9A) 4FD A 301 (-3.6A) 4FD A 301 (-3.9A) 4FD A 301 (-4.5A)	0.28A	5wyqA-4ypwA: 29.1	5wyqA-4ypwA: 62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5WYQ_B_SAMB301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4ypw	TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE (Haemophilus influenzae)	12 / 12	TYR A 86 LEU A 87 PRO A 89 GLN A 90 GLY A 113 SER A 132 ILE A 133 TYR A 136 LEU A 138 GLY A 140 GLY A 141 PRO A 144	None None 4FD A 301 ( 3.6A) None 4FD A 301 (-4.7A) 4FD A 301 (-3.2A) 4FD A 301 (-4.1A) None 4FD A 301 (-3.9A) 4FD A 301 (-3.6A) 4FD A 301 (-3.9A) 4FD A 301 (-4.5A)	0.25A	5wyqB-4ypwA: 28.2	5wyqB-4ypwA: 62.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",12,"LEU A  87;SER A  88;PRO A  89;GLN A  90;GLY A 113;SER A 132;ILE A 133;VAL A 137;LEU A 138;GLY A 140;GLY A 141;PRO A 144","None;None;4FD A 301 ( 3.6A);None;4FD A 301 (-4.7A);4FD A 301 (-3.2A);4FD A 301 (-4.1A);4FD A 301 ( 4.4A);4FD A 301 (-3.9A);4FD A 301 (-3.6A);4FD A 301 (-3.9A);4FD A 301 (-4.5A)","0.36A","1uakA-4ypwA:31.4",null],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",6,"PRO A  89;GLN A  90;GLY A 113;LEU A 138;GLY A 141;PRO A 144","4FD A 301 ( 3.6A);None;4FD A 301 (-4.7A);4FD A 301 (-3.9A);4FD A 301 (-3.9A);4FD A 301 (-4.5A)","1.21A","1uakA-4ypwA:31.4","1uakA-4ypwA:100.00"],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",6,"SER A  88;PRO A  89;GLN A  90;GLY A 113;LEU A 138;GLY A 140","None;4FD A 301 ( 3.6A);None;4FD A 301 (-4.7A);4FD A 301 (-3.9A);4FD A 301 (-3.6A)","1.26A","1uakA-4ypwA:31.4","1uakA-4ypwA:100.00"],["1UWH_A_BAXA1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",4,"VAL A  33;VAL A  99;ILE A 133;ASP A 150","None;None;4FD A 301 (-4.1A);None","0.82A","1uwhA-4ypwA:undetectable","1uakA-4ypwA:100.00"],["2QMM_A_SAMA301_0","UPF0217 PROTEIN AF_1056","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",5,"LEU A  87;GLY A 113;GLY A 117;SER A 132;LEU A 138","None;4FD A 301 (-4.7A);4FD A 301 (-3.6A);4FD A 301 (-3.2A);4FD A 301 (-3.9A)","0.80A","2qmmA-4ypwA:8.8","1uwhA-4ypwA:22.70"],["2QMM_B_SAMB301_0","UPF0217 PROTEIN AF_1056","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",5,"LEU A  87;GLY A 113;GLY A 117;SER A 132;LEU A 138","None;4FD A 301 (-4.7A);4FD A 301 (-3.6A);4FD A 301 (-3.2A);4FD A 301 (-3.9A)","0.88A","2qmmA-4ypwA:5.5;2qmmB-4ypwA:5.7","2qmmA-4ypwA:24.24"],["3AXZ_A_ADNA401_1","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",12,"TYR A  86;LEU A  87;SER A  88;PRO A  89;GLY A 113;GLY A 117;SER A 132;ILE A 133;LEU A 138;GLY A 140;GLY A 141;PRO A 144","None;None;None;4FD A 301 ( 3.6A);4FD A 301 (-4.7A);4FD A 301 (-3.6A);4FD A 301 (-3.2A);4FD A 301 (-4.1A);4FD A 301 (-3.9A);4FD A 301 (-3.6A);4FD A 301 (-3.9A);4FD A 301 (-4.5A)","0.31A","3axzA-4ypwA:31.4","2qmmA-4ypwA:24.24;2qmmB-4ypwA:24.24"],["4YVG_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",12,"LEU A  87;SER A  88;PRO A  89;GLY A 113;GLU A 116;GLY A 117;SER A 132;ILE A 133;LEU A 138;GLY A 140;GLY A 141;PRO A 144","None;None;4FD A 301 ( 3.6A);4FD A 301 (-4.7A);None;4FD A 301 (-3.6A);4FD A 301 (-3.2A);4FD A 301 (-4.1A);4FD A 301 (-3.9A);4FD A 301 (-3.6A);4FD A 301 (-3.9A);4FD A 301 (-4.5A)","0.34A","4yvgA-4ypwA:31.6","3axzA-4ypwA:100.00"],["5TWJ_A_SAMA201_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",5,"LEU A  87;GLY A 113;GLY A 117;SER A 132;LEU A 138","None;4FD A 301 (-4.7A);4FD A 301 (-3.6A);4FD A 301 (-3.2A);4FD A 301 (-3.9A)","0.73A","5twjA-4ypwA:11.0","4yvgA-4ypwA:100.00"],["5WYQ_A_SAMA401_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",12,"LEU A  87;PRO A  89;GLN A  90;GLY A 113;GLY A 117;SER A 132;ILE A 133;VAL A 137;LEU A 138;GLY A 140;GLY A 141;PRO A 144","None;4FD A 301 ( 3.6A);None;4FD A 301 (-4.7A);4FD A 301 (-3.6A);4FD A 301 (-3.2A);4FD A 301 (-4.1A);4FD A 301 ( 4.4A);4FD A 301 (-3.9A);4FD A 301 (-3.6A);4FD A 301 (-3.9A);4FD A 301 (-4.5A)","0.28A","5wyqA-4ypwA:29.1","5twjA-4ypwA:20.83"],["5WYQ_B_SAMB301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4ypw","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","Haemophilus influenzae",12,"TYR A  86;LEU A  87;PRO A  89;GLN A  90;GLY A 113;SER A 132;ILE A 133;TYR A 136;LEU A 138;GLY A 140;GLY A 141;PRO A 144","None;None;4FD A 301 ( 3.6A);None;4FD A 301 (-4.7A);4FD A 301 (-3.2A);4FD A 301 (-4.1A);None;4FD A 301 (-3.9A);4FD A 301 (-3.6A);4FD A 301 (-3.9A);4FD A 301 (-4.5A)","0.25A","5wyqB-4ypwA:28.2","5wyqA-4ypwA:62.50"]]