SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4EY'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA501_1 (CYTOCHROME P450 2C8)	5huq	LACTATE RACEMIZATION OPERON PROTEIN LARA (Lactobacillus plantarum)	5 / 11	GLY A 181 SER A 71 ILE A 190 ALA A 159 ILE A 166	4EY A 501 (-3.7A) 4EY A 501 (-3.6A) None None None	1.10A	2nnhA-5huqA: undetectable	2nnhA-5huqA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	5huq	LACTATE RACEMIZATION OPERON PROTEIN LARA (Lactobacillus plantarum)	5 / 11	ALA A 231 ALA A 159 HIS A 133 GLY A 189 ILE A 144	None None None 4EY A 501 (-3.5A) None	1.04A	2x1lA-5huqA: 2.2	2x1lA-5huqA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	5huq	LACTATE RACEMIZATION OPERON PROTEIN LARA (Lactobacillus plantarum)	5 / 12	ALA A 231 ALA A 159 HIS A 133 GLY A 189 ILE A 144	None None None 4EY A 501 (-3.5A) None	1.07A	2x1lB-5huqA: 3.1	2x1lB-5huqA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	5huq	LACTATE RACEMIZATION OPERON PROTEIN LARA (Lactobacillus plantarum)	5 / 11	ALA A 231 ALA A 159 HIS A 133 GLY A 189 ILE A 144	None None None 4EY A 501 (-3.5A) None	1.08A	2x1lC-5huqA: 3.1	2x1lC-5huqA: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N3I_A_ROCA201_1 (PROTEASE)	5huq	LACTATE RACEMIZATION OPERON PROTEIN LARA (Lactobacillus plantarum)	5 / 12	GLY A 189 ALA A 104 ASP A 72 GLY A 169 VAL A 67	4EY A 501 (-3.5A) 4EY A 501 (-4.1A) 4EY A 501 (-3.3A) None None	1.15A	3n3iA-5huqA: undetectable	3n3iA-5huqA: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_B_D16B302_1 (THYMIDYLATE SYNTHASE)	5huq	LACTATE RACEMIZATION OPERON PROTEIN LARA (Lactobacillus plantarum)	5 / 12	HIS A 174 SER A 180 ASP A 417 LEU A 419 GLY A 420	4EY A 501 ( 4.5A) 4EY A 501 (-4.7A) None None None	1.18A	4foxB-5huqA: undetectable	4foxB-5huqA: 20.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NNH_A_9CRA501_1","CYTOCHROME P450 2C8","5huq","LACTATE RACEMIZATION OPERON PROTEIN LARA","Lactobacillus plantarum",5,"GLY A 181;SER A  71;ILE A 190;ALA A 159;ILE A 166","4EY A 501 (-3.7A);4EY A 501 (-3.6A);None;None;None","1.10A","2nnhA-5huqA:undetectable",null],["2X1L_A_ADNA601_1","METHIONYL-TRNA SYNTHETASE","5huq","LACTATE RACEMIZATION OPERON PROTEIN LARA","Lactobacillus plantarum",5,"ALA A 231;ALA A 159;HIS A 133;GLY A 189;ILE A 144","None;None;None;4EY A 501 (-3.5A);None","1.04A","2x1lA-5huqA:2.2","2nnhA-5huqA:21.85"],["2X1L_B_ADNB601_1","METHIONYL-TRNA SYNTHETASE","5huq","LACTATE RACEMIZATION OPERON PROTEIN LARA","Lactobacillus plantarum",5,"ALA A 231;ALA A 159;HIS A 133;GLY A 189;ILE A 144","None;None;None;4EY A 501 (-3.5A);None","1.07A","2x1lB-5huqA:3.1","2x1lA-5huqA:23.55"],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","5huq","LACTATE RACEMIZATION OPERON PROTEIN LARA","Lactobacillus plantarum",5,"ALA A 231;ALA A 159;HIS A 133;GLY A 189;ILE A 144","None;None;None;4EY A 501 (-3.5A);None","1.08A","2x1lC-5huqA:3.1","2x1lB-5huqA:23.55"],["3N3I_A_ROCA201_1","PROTEASE","5huq","LACTATE RACEMIZATION OPERON PROTEIN LARA","Lactobacillus plantarum",5,"GLY A 189;ALA A 104;ASP A  72;GLY A 169;VAL A  67","4EY A 501 (-3.5A);4EY A 501 (-4.1A);4EY A 501 (-3.3A);None;None","1.15A","3n3iA-5huqA:undetectable","2x1lC-5huqA:23.55"],["4FOX_B_D16B302_1","THYMIDYLATE SYNTHASE","5huq","LACTATE RACEMIZATION OPERON PROTEIN LARA","Lactobacillus plantarum",5,"HIS A 174;SER A 180;ASP A 417;LEU A 419;GLY A 420","4EY A 501 ( 4.5A);4EY A 501 (-4.7A);None;None;None","1.18A","4foxB-5huqA:undetectable","3n3iA-5huqA:17.32"]]